Patents by Inventor Esko Kauppinen
Esko Kauppinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230226099Abstract: This invention relates to inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient. The present invention relates also to an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient for use in a method of treating an infection in a subject. In addition, the present invention relates to a method of treating an infection in a subject by administering an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient to the subject. The inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient is suitable for the treatment of pulmonary or systemic infections caused by Gram-positive or Gram-negative bacteria.Type: ApplicationFiled: April 7, 2021Publication date: July 20, 2023Inventors: Christopher JONKERGOUW, Nurcin UGUR, Markus LINDER, Janne RAULA, Esko KAUPPINEN, Ekaterina OSMEKHINA
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Patent number: 9556032Abstract: The present invention relates to single walled and multi-walled carbon nanotubes (CNTs), functionalized CNTs and carbon nanotube composites with controlled properties, to a method for aerosol synthesis of single walled and multi-walled carbon nanotubes, functionalized CNTs and carbon nanotube composites with controlled properties from pre-made catalyst particles and a carbon source in the presence of reagents and additives, to functional, matrix and composite materials composed thereof and structures and devices fabricated from the same in continuous or batch CNT reactors. The present invention allows all or part of the processes of synthesis of CNTs, their purification, doping, functionalization, coating, mixing and deposition to be combined in one continuous procedure and in which the catalyst synthesis, the CNT synthesis, and their functionalization, doping, coating, mixing and deposition can be separately controlled.Type: GrantFiled: June 30, 2014Date of Patent: January 31, 2017Assignee: CANATU OYInventors: Esko Kauppinen, David P. Brown, Albert G. Nasibulin, Hua Jiang, Anna Moisala Motta
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Publication number: 20140348721Abstract: The present invention relates to single walled and multi-walled carbon nanotubes (CNTs), functionalized CNTs and carbon nanotube composites with controlled properties, to a method for aerosol synthesis of single walled and multi-walled carbon nanotubes, functionalized CNTs and carbon nanotube composites with controlled properties from pre-made catalyst particles and a carbon source in the presence of reagents and additives, to functional, matrix and composite materials composed thereof and structures and devices fabricated from the same in continuous or batch CNT reactors. The present invention allows all or part of the processes of synthesis of CNTs, their purification, doping, functionalization, coating, mixing and deposition to be combined in one continuous procedure and in which the catalyst synthesis, the CNT synthesis, and their functionalization, doping, coating, mixing and deposition can be separately controlled.Type: ApplicationFiled: June 30, 2014Publication date: November 27, 2014Inventors: Esko KAUPPINEN, David P. BROWN, Albert G. NASIBULIN, Hua JIANG, Anna MOISALA
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Patent number: 8845995Abstract: The present invention relates to single walled and multi-walled carbon nanotubes (CNTs), functionalized CNTs and carbon nanotube composites with controlled properties, to a method for aerosol synthesis of single walled and multi-walled carbon nanotubes, functionalized CNTs and carbon nanotube composites with controlled properties from pre-made catalyst particles and a carbon source in the presence of reagents and additives, to functional, matrix and composite materials composed thereof and structures and devices fabricated from the same in continuous or batch CNT reactors. The present invention allows all or part of the processes of synthesis of CNTs, their purification, doping, functionalization, coating, mixing and deposition to be combined in one continuous procedure and in which the catalyst synthesis, the CNT synthesis, and their functionalization, doping, coating, mixing and deposition can be separately controlled.Type: GrantFiled: March 9, 2005Date of Patent: September 30, 2014Assignee: Canatu OyInventors: Esko Kauppinen, David P. Brown, Albert G. Nasibulin, Hua Jiang, Anna Moisala
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Publication number: 20080254127Abstract: Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof. The particles have a narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.Type: ApplicationFiled: May 30, 2007Publication date: October 16, 2008Inventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen
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Patent number: 7267813Abstract: Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof. The particles have a narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.Type: GrantFiled: October 5, 2001Date of Patent: September 11, 2007Assignee: Orion CorporationInventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen
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Publication number: 20070148962Abstract: The present invention relates to single walled and multi-walled carbon nanotubes (CNTs), functionalized CNTs and carbon nanotube composites with controlled properties, to a method for aerosol synthesis of single walled and multi-walled carbon nanotubes, functionalized CNTs and carbon nanotube composites with controlled properties from pre-made catalyst particles and a carbon source in the presence of reagents and additives, to functional, matrix and composite materials composed thereof and structures and devices fabricated from the same in continuous or batch CNT reactors. The present invention allows all or part of the processes of synthesis of CNTs, their purification, doping, functionalization, coating, mixing and deposition to be combined in one continuous procedure and in which the catalyst synthesis, the CNT synthesis, and their functionalization, doping, coating, mixing and deposition can be separately controlled.Type: ApplicationFiled: March 9, 2005Publication date: June 28, 2007Inventors: Esko Kauppinen, David Brown, Albert Nasibulin, Hua Jiang, Anna Moisala
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Patent number: 7172752Abstract: Inhalation particles incorporating, in an individual particle, a combination of a ?hd 2-agonist and a glucocorticosteroid in a predetermined and constant ratio, a process for the preparation thereof and pharmaceutical compositions comprising the inhalation particles. The particles have a narrow particle size distribution and are preferably in the form of spherical crystalline particles with a rough surface. The particles are particularly useful in the treatment of asthma and other respiratory disorders.Type: GrantFiled: October 5, 2001Date of Patent: February 6, 2007Assignee: Orion CorporationInventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen
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Patent number: 6983748Abstract: A device for delivering a powdered medicament by inhalation comprises an air inlet passage having low pressure-drop and low turbulence for stabilizing air flow before aerosolization, a dosing cup in the region of reduced air velocity to delay aerosolization, a high pressure drop throat to generate a high velocity flow, a rapidly expanding diverging passage to create a free jet of air with high turbulence and an outlet passage having large cross-sectional area to control the rate of dissipation of the free jet. The device is simple yet capable of consistently providing uniform and effective powder aerosolization and deagglomeration over a variety of patient inhalation profiles.Type: GrantFiled: October 26, 2001Date of Patent: January 10, 2006Assignee: Orion CorporationInventors: David Brown, Esko Kauppinen, Juha Kurkela, Wiwik Watanabe, Jorma Jokiniemi, Esa Muttonen
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Publication number: 20040091542Abstract: The invention relates to free nano-sized particles of active agents e.g. therapeutic, cosmetic or diagnostic agents, and to a method for the preparation of such particles. The method comprises providing a liquid feed stock comprising an active agent or combination of two or more active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Nano-sized crystalline spherical uncharged particles with narrow aerodynamic particle size distribution and rough surfaces, are obtained. The particles show improved dissolution rate in-vitro and bioavailability in-vivo, dispersibility and stability.Type: ApplicationFiled: December 11, 2003Publication date: May 13, 2004Inventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen
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Publication number: 20040069303Abstract: A device for delivering a powdered medicament by inhalation comprises an air inlet passage having low pressure-drop and low turbulence for stabilizing air flow before aerosolization, a dosing cup in the region of reduced air velocity to delay aerosolization, a high pressure drop throat to generate a high velocity flow, a rapidly expanding diverging passage to create a free jet of air with high turbulence and an outlet passage having large cross-sectional area to control the rate of dissipation of the free jet. The device is simple yet capable of consistently providing uniform and effective powder aerosolization and deagglomeration over a variety of patient inhalation profiles.Type: ApplicationFiled: October 1, 2003Publication date: April 15, 2004Inventors: David Brown, Esko Kauppinen, Juha Kurkela, Wiwik Watanabe, Jorma Jokiniemi, Esa Muttonen
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Publication number: 20040052732Abstract: Inhalation particles incorporating, in an individual particle, a combination of a &bgr;hd 2-agonist and a glucocorticosteroid in a predetermined and constant ratio, a process for the preparation thereof and pharmaceutical compositions comprising the inhalation particles. The particles have a narrow particle size distribution and are preferably in the form of spherical crystalline particles with a rough surface. The particles are particularly useful in the treatment of asthma and other respiratory disorders.Type: ApplicationFiled: August 14, 2003Publication date: March 18, 2004Inventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen
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Publication number: 20040028619Abstract: Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof are disclosed. The particles have narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.Type: ApplicationFiled: August 14, 2003Publication date: February 12, 2004Inventors: Wiwik Watanabe, Esko Kauppinen, Petri Ahonen, David Brown, Esa Muttonen