Patents by Inventor Esmaiel Jabbari
Esmaiel Jabbari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230355541Abstract: The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.Type: ApplicationFiled: April 28, 2023Publication date: November 9, 2023Inventor: ESMAIEL JABBARI
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Patent number: 11672767Abstract: The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.Type: GrantFiled: March 6, 2020Date of Patent: June 13, 2023Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20230122977Abstract: Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction.Type: ApplicationFiled: March 10, 2022Publication date: April 20, 2023Applicant: University of South CarolinaInventor: Esmaiel Jabbari
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Patent number: 11607393Abstract: Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsesquioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.Type: GrantFiled: December 14, 2020Date of Patent: March 21, 2023Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Patent number: 11058797Abstract: Compositions and implants for articular cartilage repair or regeneration are described. The compositions are hydrogel-based compositions that can incorporate signaling molecules for cartilage repair. The compositions include microcapsules having predetermined erosion profiles that are loaded with nanogels having predetermined sustained release profiles for signaling molecules conjugated to the nanogels. A plurality of compositions, each carrying different signaling molecules, can be layered to form a multi-layered implant, with each layer sequentially releasing the encapsulated signaling molecules over a predetermined period of time. The compositions can carry additional components to encourage tissue generation such as stem cells and extracellular matrix (ECM) components.Type: GrantFiled: February 15, 2018Date of Patent: July 13, 2021Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20210205493Abstract: Injectable compositions and use of the injectable compositions in tissue engineering applications are described. The injectable compositions are hydrogel-based compositions that can be crosslinked in situ following placement. The injectable compositions include microcapsules having predetermined erosion profiles that are loaded with nanogels having predetermined sustained release profiles for signaling molecules conjugated to the nanogels. Following crosslinking, the compositions are designed to sequentially release signaling molecules over a predetermined period of time with various release profiles. The compositions can carry additional components to stimulate tissue generation such as stem cells and extracellular matrix (ECM) components.Type: ApplicationFiled: March 1, 2021Publication date: July 8, 2021Inventor: ESMAIEL JABBARI
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Publication number: 20210121412Abstract: Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsesquioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.Type: ApplicationFiled: December 14, 2020Publication date: April 29, 2021Inventor: ESMAIEL JABBARI
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Patent number: 10967098Abstract: Injectable compositions and use of the injectable compositions in tissue engineering applications are described. The injectable compositions are hydrogel-based compositions that can be crosslinked in situ following placement. The injectable compositions include microcapsules having predetermined erosion profiles that are loaded with nanogels having predetermined sustained release profiles for signaling molecules conjugated to the nanogels. Following crosslinking, the compositions are designed to sequentially release signaling molecules over a predetermined period of time with various release profiles. The compositions can carry additional components to stimulate tissue generation such as stem cells and extracellular matrix (ECM) components.Type: GrantFiled: February 15, 2018Date of Patent: April 6, 2021Assignee: University' of South CarolinaInventor: Esmaiel Jabbari
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Patent number: 10894019Abstract: Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsequioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.Type: GrantFiled: August 8, 2018Date of Patent: January 19, 2021Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20200360295Abstract: The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.Type: ApplicationFiled: March 6, 2020Publication date: November 19, 2020Inventor: ESMAIEL JABBARI
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Patent number: 10836994Abstract: A three-dimensional cell culture system that includes a keratin-based hydrogel precursor solution and a cell culture vessel is provided. The precursor solution includes solubilized keratin that has been functionalized to include a crosslinking moiety. The crosslinking moiety exhibits controllable crosslinking, e.g., a photopolymerizable crosslinking moiety. The crosslinking functionality is bonded to the keratin via cysteines following reduction of disulfide bonds of the native keratin. The precursor solution can be combined with cells to form a cell suspension that is disposed on a surface of the cell culture vessel. Alternatively, the cells can be added to a surface of a keratin-based hydrogel that has been formed on a surface of the cell culture vessel. The resulting three-dimensional cell culture system is a biomimetic/biologic, trypsin-degradable cell culture system for expansion of mammalian cells. The expanded cells are expected to possess a morphology similar to the primary cells prior to cultivation.Type: GrantFiled: November 16, 2017Date of Patent: November 17, 2020Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Patent number: 10723774Abstract: Keratin-based hydrogels and aqueous compositions and methods for forming the hydrogels and compositions are described. The compositions include solubilized keratin that has been functionalized to include a crosslinking moiety. The crosslinking moiety exhibits controllable crosslinking, e.g., a photopolymerizable crosslinking moiety. The crosslinking functionality is bonded to the keratin via cysteines following reduction of disulfide bonds of the native keratin. The compositions can be injectable and can include living cells and/or other biologically active agents, for instance for use in tissue regeneration.Type: GrantFiled: November 16, 2017Date of Patent: July 28, 2020Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20200040296Abstract: A microcarrier for cell culture and expansion is provided. The microcarrier includes decellularized mammalian tissue. Further, the microcarrier has an average particle size ranging from about 10 micrometers to about 600 micrometers. A method of forming a decellularized mammalian tissue microcarrier for cell culture and expansion is also provided, along with a method for treating a mammalian tissue defect via a decellularized mammalian tissue microcarrier on which cells from the same tissue type as the decellularized mammalian tissue are expanded.Type: ApplicationFiled: July 15, 2019Publication date: February 6, 2020Inventor: Esmaiel JABBARI
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Patent number: 10494610Abstract: Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.Type: GrantFiled: November 30, 2018Date of Patent: December 3, 2019Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20190085298Abstract: Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.Type: ApplicationFiled: November 30, 2018Publication date: March 21, 2019Inventor: Esmaiel Jabbari
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Patent number: 10227566Abstract: Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.Type: GrantFiled: October 29, 2014Date of Patent: March 12, 2019Assignee: University of South CarolinaInventor: Esmaiel Jabbari
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Publication number: 20190054034Abstract: Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsequioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.Type: ApplicationFiled: August 8, 2018Publication date: February 21, 2019Inventor: ESMAIEL JABBARI
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Publication number: 20190048321Abstract: Disclosed are culture systems and methods that can enrich a cancer cell population in cancer stem cells. The culture system can be utilized for study of cancer stem cells in general as well as for cancer drug screening. The methods and systems include co-culturing of a cancer cell population and programable macrophages, which can lead to proliferation of the cancer stem cells of the population and depletion of differentiated cancer cells of the population. The methods and systems can provide a more reliable and accurate model for preclinical drug toxicity testing.Type: ApplicationFiled: August 8, 2018Publication date: February 14, 2019Inventor: ESMAIEL JABBARI
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Publication number: 20180273899Abstract: A three-dimensional cell culture system that includes a keratin-based hydrogel precursor solution and a cell culture vessel is provided. The precursor solution includes solubilized keratin that has been functionalized to include a crosslinking moiety. The crosslinking moiety exhibits controllable crosslinking, e.g., a photopolymerizable crosslinking moiety. The crosslinking functionality is bonded to the keratin via cysteines following reduction of disulfide bonds of the native keratin. The precursor solution can be combined with cells to form a cell suspension that is disposed on a surface of the cell culture vessel. Alternatively, the cells can be added to a surface of a keratin-based hydrogel that has been formed on a surface of the cell culture vessel. The resulting three-dimensional cell culture system is a biomimetic/biologic, trypsin-degradable cell culture system for expansion of mammalian cells. The expanded cells are expected to possess a morphology similar to the primary cells prior to cultivation.Type: ApplicationFiled: November 16, 2017Publication date: September 27, 2018Inventor: Esmaiel Jabbari
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Publication number: 20180256780Abstract: Compositions and implants for articular cartilage repair or regeneration are described. The compositions are hydrogel-based compositions that can incorporate signaling molecules for cartilage repair. The compositions include microcapsules having predetermined erosion profiles that are loaded with nanogels having predetermined sustained release profiles for signaling molecules conjugated to the nanogels. A plurality of compositions, each carrying different signaling molecules, can be layered to form a multi-layered implant, with each layer sequentially releasing the encapsulated signaling molecules over a predetermined period of time. The compositions can carry additional components to encourage tissue generation such as stem cells and extracellular matrix (ECM) components.Type: ApplicationFiled: February 15, 2018Publication date: September 13, 2018Inventor: Esmaiel Jabbari