Patents by Inventor Essam Abdelalim

Essam Abdelalim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF INDUCED PLURIPOTENT STEM CELL LINES FROM HUMAN PATIENTS WITH MUTATIONS IN THE GLUCOKINASE GENE
    Publication number: 20240117317
    Abstract: Heterozygous and homozygous mutations in the glucokinase (GCK) gene lead to maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes (PNDM), respectively. The present invention relates to a method for generating induced pluripotent stem cell (iPSC) lines from patients with MODY2 and PNDM due to mutations in the GCK gene. The generated iPSC lines are able to differentiate into the three germ layers and show normal karyotypes. These iPSC lines can serve as valuable human cell models for understanding diabetes pathogenesis and developing new therapies for diabetes.
    Type: Application
    Filed: February 7, 2022
    Publication date: April 11, 2024
    Inventors: Essam Abdelalim, Khalid Hussain