Abstract: The present invention relates to method and means for treating a vascularized solid tumor using a number of, in vitro prepared, anticellular agent(s)-carrying blood platelets to induce a thrombus formation within the tumor vasculature, and at the same time to deliver a high concentration of an anticellular agent within the tumor. The blood platelets are targeted and attached to the tumor vasculature using in vivo assembled binding complexes, each having at least one binding site specifically binding to tumor cells or to tumor-associated vasculature, and at least one binding site specifically binding to a blood platelet surface. The platelet-mediated thrombus formed within the tumor vasculature leads to occlusion of the tumor vasculature, with ultimate destruction of the centrally located tumor cells. This is followed by destruction or suppressing the growth or cell division of the peripherally located tumor cells, by the anticellular agent(s) carried by the blood platelets.

Abstract: The present invention relates to method and means for treating a vascularized solid tumor using a number of, in vitro prepared, anticellular agent(s)-carrying blood platelets to induce a thrombus formation within the tumor vasculature, and at the same time to deliver a high concentration of an anticellular agent within the tumor. The blood platelets are targeted and attached to the tumor vasculature using in vivo assembled binding complexes, each having at least one binding site specifically binding to tumor cells or to tumor-associated vasculature, and at least one binding site specifically binding to a blood platelet surface. The platelet-mediated thrombus formed within the tumor vasculature leads to occlusion of the tumor vasculature, with ultimate destruction of the centrally located tumor cells. This is followed by destruction or suppressing the growth or cell division of the peripherally located tumor cells, by the anticellular agent(s) carried by the blood platelets.

Abstract: A radial out-flowing rotary ram-in compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes defining a feeding channel in-between. In operation, working gases are rammed through the feeding channels in a generally radially outward direction, followed by positive displacement of the rammed-in gases to a receiver wherein pressurized gases collect. The pressurized gases are actively swept from the receiver by either a successive rotary ram-in compressor or a successive rotary ram compressor.

Abstract: The present invention provides a supercharged open cycle gas turbine engine comprising a core engine for generating shaft power output; a supercharger for increasing the density and pressure of intake air of the core engine, said supercharger includes a rotary ram-in compressor; a receiver; and a turbine having variable-area nozzle assembly; at least one conduit for communicating the supercharger's receiver with its surrounding atmospheric air, said conduit being provided with a valve for controlling the flow of air through it; at least one pressure sensor for detecting the degree of rise in the pressure of air supplied by the supercharger's compressor; means for adjusting the area of the nozzles of the supercharger's turbine according to the detected degree of rise in the air pressure; and means for adjusting the rate of fuel supply to the core engine according to the pressure level of air supplied by the supercharger's compressor.

Abstract: A rotary ram compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes and the opposing parts of the disks' surfaces confined between the opposing parts of the surfaces of the two adjacent vanes defining a channel in-between. Each channel is formed of two successive freely communicating portions: a first diverging inlet portion; and a second constant cross-sectional area outlet portion. In operation, gases are rammed into the first diverging inlet portion of the channel and are gradually displaced to the second constant cross-sectional area outlet portion of the channel, while being diverged, resulting into a rise in the static pressure energy of the gases, followed by smoothening of the stream of flow of the pressurized gases within the second constant cross-sectional area outlet portion of the channel.

Abstract: The present invention provides a method for treating cancer in a mammal and to multicomponent conjugates useful in such treatment. In particular, it provides a cancer treatment method that includes administering multicomponent conjugates of formula: A-B-C, where “B” may be present or absent, “A” comprises at least one specific anti-cancer binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on the outer surface of a cancer cell, “B” comprises at least one molecule to which “A” and “C” bind, such as a biotin-avidin-biotin complex, “C” comprises at least one specific anti-platelet binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on the outer surface of a blood platelet.

Abstract: A rotary ram-out vacuum pump, used for decreasing the pressure of a gas within a space ahead of the vacuum pump, comprising: a stationary casing having at least one inlet passage communicating with the space ahead of the vacuum pump, and at least one exit passage freely communicating with surrounding atmospheric air; a drive shaft supported for rotation inside the casing; and a rotor assembly housed inside the casing and including a plurality of sweeping channels. In operation, gas is rammed out, through the sweeping channels of the vacuum pump, from the space ahead of the vacuum pump to surrounding atmospheric air, and thus decreasing the density and pressure of the gas in the space ahead of the vacuum pump.

Abstract: The present invention provides a method for decreasing the number of free virus particles within the bodily fluids of a mammal infected by a virus, comprising the steps of: a) specifying the type of the pathogenic virus; b) providing a supply of host cells susceptible to the specified virus type; c) treating the host cells provided in step (b) with one, or more than one viral replication inhibiting means; d) washing the host cells prepared in step (c) with a sterile physiological medium; and e) administering the host cells prepared in step (d) to the mammal. The host cells are administered to the mammal either by intravenous injection, injection into the CSF, or spraying within its respiratory tract passages.

Abstract: The present invention provides a method for treating cancer in a mammal and to using multicomponent conjugates of formula: A--B--C, where “B” may be present or absent, “A” comprises at least one specific anti-tumor binding protein recognizing a tumor associated receptor, “B” comprises at least one molecule to which “A” and “C” bind, “C” comprises at least one specific anti-platelet binding protein recognizing a receptor present on the outer surface of a blood platelet. The multicomponent conjugates provide the exquisite binding specificity, which enables attaching the blood platelets either to the outer surface of the cancer cells, or to the outer surface of a component of the tumor associated vasculature or stroma, and thus, stimulating the formation of blood clots within the blood vessels around and in-between cancer cells, leading to their destruction.

Abstract: The present invention provides compound protein molecules for inducing cytotoxic cell-mediated immune response in a mammal against a pathogenic cell displaying an antigen on its outer surface. In a preferred embodiment, the compound protein molecule comprises in sequence: a foreign class I MHC molecule; a linking (Fab) antibody fragment; an alpha-helix shaped chain linker; and a (Fab) fragment of an antibody specific against the antigen displayed by the pathogenic cell. In another preferred embodiment, the compound protein molecule comprises in sequence: a foreign class I MHC molecule; a linking (Fab) antibody fragment; an alpha-helix shaped chain linker; a (Fab?2) fragment of an antibody specific against the antigen displayed by the pathogenic cell; an alpha-helix shaped chain linker; a linking (Fab) antibody fragment; and a foreign class I MHC molecule. Methods for inducing an immune response using these compound protein molecules are also disclosed.

Abstract: A rotary ram-in compressor, used for pressurizing a gas into a container, comprising: a stationary casing having at least one inlet passage, and a receiver; at least one conduit for communicating the receiver with the container; a drive shaft supported for rotation in a given direction inside the casing; and a rotor assembly housed inside the casing and including at least one rotary ram-in compressor stage. In operation, gas is rammed through the feeding channels of the rotary ram-in compressor to the compressor's receiver, from which it flows through the conduit to the container, wherein it collects. In preferred embodiments, valve means for controlling the flow of gas through the conduit, and a pressure sensor(s) for detecting the degree of rise in the pressure of gas supplied by the rotary ram-in compressor, are also provided.

Abstract: The present invention provides a supercharged open cycle gas turbine engine comprising a core engine for generating shaft power output, said core engine includes a multi-stage compressor, the first stage of which being a rotary ram compressor or a rotary ram-in compressor; a supercharger for increasing the pressure of intake air of the core engine, said supercharger includes a rotary ram-in compressor and a turbine driven by gases discharged from the core engine and having variable-area nozzle assembly; operator controlled means for elective bleeding of variable part of the exhaust gases discharged from the core engine and supplied to the supercharger turbine; at least one pressure sensor for detecting the degree of rise in the pressure of air supplied by the supercharger's compressor; means for adjusting the area of the nozzles of the supercharger's turbine according to the detected degree of rise in the air pressure; and means for adjusting the rate of fuel supply to the core engine according to the pressur

Abstract: A rotary ram-in compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes defining a feeding channel in-between. In operation, working gases are rammed through the feeding channels, followed by positive displacement of the rammed-in gases to a receiver wherein pressurized gases collect. The pressurized gases are actively swept from the receiver by either a successive rotary ram-in compressor or a successive rotary ram compressor.