Patents by Inventor Essam M. Abdelalim

Essam M. Abdelalim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cofactors FAD and PLP for Promoting Pancreatic Progenitors in Pancreatic Development
    Publication number: 20240141299
    Abstract: The instant disclosure relates to methods and compositions for increasing ?-cell production from stem cells.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 2, 2024
    Inventors: Prasanna R. Kolatkar, Essam M. Abdelalim, Noura Aldous, Zeyaul Islam
  • GENERATION OF INDUCED PLURIPOTENT STEM CELLS (IPSCs) WITH GLUT2 MUTATION OR FOXA2 DELETION, METHODS OF PREPARING SAME, AND METHODS OF USING SAME
    Publication number: 20210230557
    Abstract: The present disclosure generally relates to the method of generating human induced pluripotent stem cells (hiPSC) from patients with either heterozygous deletion of the FOX2A gene or GLUT2 (SLC2A2) gene mutations. The methods disclosed herein generate human cell models for diabetes, Fanconi Bickel Syndrome (FBS), dysmporphic features, growth hormone deficiency, central hypothyroidism, and related disorders. The methods disclosed herein generate patient-specific iPSC cell lines that could be used by researchers to perform mechanistic studies, drug screening, and understanding the role of GLUT2 or FOXA2 in specific human cell types.
    Type: Application
    Filed: January 28, 2021
    Publication date: July 29, 2021
    Inventors: Essam M. Abdelalim, Ahmed K. Elsayed, Khalid Hussain