Patents by Inventor Esteban Bornancini

Esteban Bornancini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    Patent number: 8465777
    Abstract: The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: June 18, 2013
    Assignee: The Massachusetts Institute of Technology
    Inventors: Chen-Chao Wang, Jaedeok Yoo, Esteban Bornancini, Willie J Roach, Monica Tejwani
  • Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    Publication number: 20120177696
    Abstract: The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
    Type: Application
    Filed: November 29, 2011
    Publication date: July 12, 2012
    Applicant: THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Chen-Chao WANG, Jaedeok YOO, Esteban BORNANCINI, Willie J. ROACH, Monica TEJWANI
  • Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    Patent number: 8088415
    Abstract: The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: January 3, 2012
    Assignee: The Massachusetts Institute of Technology
    Inventors: Chen-Chao Wang, Jaedeok Yoo, Esteban Bornancini, Willie J. Roach, Monica Rewachand Motwani
  • Diffusion-controlled dosage form and method of fabrication including three dimensional printing
    Publication number: 20040005360
    Abstract: The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Applicant: Therics, Inc.
    Inventors: Chen-Chao Wang, Jaedeok Yoo, Esteban Bornancini, Willie J. Roach, Monica Rewachand Motwani
  • Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
    Patent number: 6514518
    Abstract: Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: February 4, 2003
    Assignee: Therics, Inc.
    Inventors: Donald Monkhouse, Jaedeok Yoo, Jill K. Sherwood, Michael J. Cima, Esteban Bornancini
  • Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
    Publication number: 20020018816
    Abstract: Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
    Type: Application
    Filed: August 17, 2001
    Publication date: February 14, 2002
    Inventors: Donald Monkhouse, Jaedeok Yoo, Jill K. Sherwood, Michael J. Cima, Esteban Bornancini
  • Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
    Patent number: 6280771
    Abstract: Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: August 28, 2001
    Assignees: Therics, Inc., Massachusetts Institute of Technology
    Inventors: Donald Monkhouse, Jaedeok Yoo, Jill K. Sherwood, Michael J. Cima, Esteban Bornancini