Patents by Inventor Ester Ascione

Ester Ascione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for plasminogen purification starting from human plasma
    Patent number: 11591587
    Abstract: The present invention provides a process for the production of human plasminogen starting from human plasma or a fractionation intermediate thereof. The main stages of the process are: a step of virus inactivation, in which human plasma is contacted with a solvent/detergent mixture, a single affinity chromatographic step and a virus removal nanofiltration step. This process is scalable up to industrial level and it provides, without adding any protease inhibitor, a functional and intact finished product suitable to be administered for the treatment of human diseases due to genetic plasminogen deficiency.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: February 28, 2023
    Assignee: KEDRION S.P.A.
    Inventors: Ester Ascione, Claudio Farina, Alessandra Lazzarotti, Marcella Maddaluno, Claudia Nardini
  • PROCESS FOR PLASMINOGEN PURIFICATION STARTING FROM HUMAN PLASMA
    Publication number: 20190330611
    Abstract: The present invention provides a process for the production of human plasminogen starting from human plasma or a fractionation intermediate thereof. The main stages of the process are: a step of virus inactivation, in which human plasma is contacted with a solvent/detergent mixture, a single affinity chromatographic step and a virus removal nanofiltration step. This process is scalable up to industrial level and it provides, without adding any protease inhibitor, a functional and intact finished product suitable to be administered for the treatment of human diseases due to genetic plasminogen deficiency.
    Type: Application
    Filed: September 12, 2017
    Publication date: October 31, 2019
    Inventors: Ester ASCIONE, Claudio FARINA, Alessandra LAZZAROTTI, Marcella MADDALUNO, Claudia NARDINI
  • Transferrin for use in the treatment and/or prophylaxis of autoimmune diseases
    Patent number: 9138454
    Abstract: The present invention describes pharmaceutical compositions containing APOTf for use in preventing (or delaying the onset) and treating autoimmune diseases. Based on the experimental data obtained, the molecule has the surprising capacity to favorably modify the immune response profile both in vitro and in vivo.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: September 22, 2015
    Assignee: KEDRION S.P.A.
    Inventors: Claudio Farina, Ester Ascione, Pierangelo Giovacchini, Ferdinando Nicoletti
  • TRANSFERRIN FOR USE IN THE TREATMENT AND/OR PROPHYLAXIS OF AUTOIMMUNE DISEASES
    Publication number: 20120296071
    Abstract: The present invention describes pharmaceutical compositions containing APOTf for use in preventing (or delaying the onset) and treating autoimmune diseases. Based on the experimental data obtained, the molecule has the surprising capacity to favourably modify the immune response profile both in vitro and in vivo.
    Type: Application
    Filed: February 15, 2011
    Publication date: November 22, 2012
    Inventors: Claudio Farina, Ester Ascione, Pierangelo Giovacchini, Ferdinando Nicoletti