Patents by Inventor Ester Boix

Ester Boix has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant form of a cytotoxic ribonucleolytic protein which allows production by recombinant methods
    Patent number: 6649392
    Abstract: The present invention provides recombinant Onc (rOnc) compositions and methods. Recombinant Onc proteins of the invention have an amino terminal methionine and comprise an Onc polypeptide. The amino terminal methionine of the protein allows for recombinant production in a bacterial host cell. Cleaving the amino terminal methionine exposes the amino terminal glutamine of the polypeptide. The Onc polypeptide has an amino terminal glutamine. Cyclization of the amino terminal glutamine of the polypeptide to a pyroglutamyl residue provides rOnc polypeptides and proteins have anti-cancer and anti-viral activity.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: November 18, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard J. Youle, Veena M. Vasandani, Yon-Neng Wu, Ester Boix, Wojciech Ardelt
  • Mutant form of cytotoxic ribonucleolytic protein which allows production by recombinant methods
    Patent number: 6649393
    Abstract: The present invention provides recombinant Onc (rOnc) compositions and methods. Recombinant Onc proteins of the invention have an amino terminal methionine and comprise an Onc polypeptide. The amino terminal methionine of the protein allows for recombinant production in a bacterial host cell. Cleaving the amino terminal methionine exposes the amino terminal glutamine of the polypeptide. The Onc polypeptide has an amino terminal glutamine. Cyclization of the amino terminal glutamine of the polypeptide to a pyroglutamyl residue provides rOnc polypeptides and proteins have anti-cancer and anti-viral activity.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: November 18, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard J. Youle, Veena M. Vasandani, Yon-Neng Wu, Ester Boix, Wojciech Ardelt