Patents by Inventor Ester Piek

Ester Piek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Smad2 phosphorylation and interaction with Smad4
    Publication number: 20020146774
    Abstract: The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation and activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway-restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 10, 2002
    Inventors: Serhiy Souchelnytskyi, Kiyoshi Tamaki, Ulla Engstrom, Christer Wernstedt, Ester Piek, Peter Ten Dijke, Carl-Henrik Heldin
  • Smad2 phosphorylation and interaction with Smad4
    Patent number: 6368829
    Abstract: The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation and activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway-restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: April 9, 2002
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Serhly Souchelnytskyi, Kiyoshi Tamaki, Ulla Engotröm, Christer Wornstedt, Ester Piek, Peter Bon Dijke, Carl-Henrik Heldin
  • Smad2 phosphorylation and interaction with Smad4
    Patent number: 6103869
    Abstract: The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation and activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway-restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: August 15, 2000
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Serhiy Souchelnytokyi, Kiyoshi Tamaki, Ulla Engetrom, Christer Wernstedt, Ester Piek, Peter ton Dijke, Carl-Henrik Heldin