Abstract: A novel silver-lithium-iodine solid-state energy device and system are disclosed. The rechargeable, self-assembled, dual-function, metal-iodide battery exhibits small size and high deliverable power. Inert until activation, the device may be stored for long periods of time. Upon activation, the device assembles the required electrochemical moieties for operation without external intervention. The device limits short-circuiting and self-discharge of the system by spontaneous reactions at the electrode/electrolyte interfaces, and thus is self-healing. By incorporating both silver and lithium in the same system, a dual function is achieved, whereby the characteristics of a lithium-based battery dominate at a low load and those of a silver-based battery dominate under a high load.

Abstract: The present invention relates to antibodies which bind to TNF? and exhibit modified FcRn-binding. The antibodies of the invention have good effector functions and/or pharmacokinetic properties.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: This disclosure provides systems, methods, and devices for image signal processing that support hardware-based photographic and videographic effects. In a first aspect, a method of image processing includes receiving, by an image signal processor, first image data; and determining an output image frame based on the first image data by applying a photographic effect to a first image frame of the first image data in the image signal processor. Other aspects and features are also claimed and described.

Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.

Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.

Abstract: A stackable nesting dollhouse includes a first component, a second component, and a third component. The first component includes a first upper wall, a first lower wall, a first left wall, and a first right wall, wherein the first upper wall may be located lower than the plane formed by the first left wall, the first rear wall, and the first right wall, creating a first offset. The second component includes a second upper wall, a second lower wall, a second left wall, and a second right wall, wherein the second upper wall may be located lower than the plane formed by the second left wall, the second rear wall, and second right wall, creating a second offset, wherein the second component is sized to be stacked on or nested within the first component. The third component is sized to be stacked on or nested within the second component.

Abstract: It is provided a method for transferring and managing data packages between a first portable secure element, SE, server implemented in a portable device (100, 200) and a second portable SE server implemented in an embedded UICC, eUICC (120, 240), comprised in a user's device (110, 230) which is local to the portable device (100, 200), the first and second portable SE severs comprising Subscription Manager, SM, functionalities, the method comprises the first and the second portable SE servers establishing off-line communication using local data transport protocols in a secured mode, the first or the second portable SE server implementing first transfer functionalities (140) for performing secure transfer of the data packages and the first or the second portable SE server implementing second transfer functionalities (140) for performing end-to-end securing of the data packages after the secure transfer of the data packages.

Abstract: A comparator circuit with a speed control element is disclosed herein. The speed control element may include a variable voltage source and one or more transistors. Using a voltage supplied by the variable voltage source, the one or more transistors may control a swing of a clock signal to provide a swing controlled clock signal to an amplification portion of the comparator circuit. The swing controlled clock therefor may be used to control the speed of the comparator circuit (e.g., an amplification phase) based on a level of noise in the circuit. The swing controlled clock may further be used to align an output common voltage of the comparator circuit with switching voltages of downstream logic cells (e.g., inverters) connected to the comparator circuit.

Abstract: A heat management system includes an electronic control unit configured to determine at least one route section-related historical heating or cooling effect profile based on heat management-relevant data of a navigation system acquired for a predefined period, acquire, for the same predefined period, a route section-related historic temperature profile by sensor for each component, determine at least one route section-related predicted heating or cooling effect profile based on the heat management-relevant data of the navigation system, which are predictable for at least one predefined horizon, and ascertain a predicted temperature profile for each component on the basis of the historic heating or cooling effect profile, the historical temperature profile, and the predicted heating or cooling effect profile.

Abstract: The present invention relates to a compound of formula (I) wherein R1 represents H, (C1-C6)alkyl-; hydroxy-(C1-C6)alkyl-; NH2—(C1-C6)alkyl-; NH—(C1-C6)alkyl-(C1-C6)alkyl-; N((C1-C6)alkyl)2-(C1-C6)alkyl-; (C2-C6)alkenyl-; (C2-C6)alkynyl-; phenyl(C1-C6)alkyl-; (C3-C10)cycloalkyl(C1-C6)alkyl-; (C3-C10)membered heterocycloalkyl(C1-C6)alkyl-; (C5-C10)membered heteroaryl(C1-C6)alkyl-; (C3-C10)membered heterocycloalkyl-NH—(C1-C16)alkyl-; and (C3-C10)membered heterocycloalkyl-N(C(O)—(C1-C6)alkyl)-(C1-C16)alkyl-; R2 represents a halogen atom, a (C1-C6)alkyl- group or other well defined groups; and R3 represents a deuterium atom; H, (C1-C6)alkyl-; (C2-C6)alkenyl-; (C2-C6)alkynyl-; (C1-C6)alkylthio-; —OR6; —NR7R8; (C3-C10)membered heterocycloalkyl-; (C5-C10)membered heteroaryl-; —(C6-C10)membered aryl; and (C3-C10)cycloalkyl-.

Abstract: The present invention relates to anti-HLA-G antibodies and methods of using the same.

Abstract: Methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents.

Abstract: A flexible photovoltaic (PV) cell having enhanced properties of mechanical impact absorption, includes: a semiconductor wafer that is freestanding and carrier-less; having a thickness, and having a first surface, and a having second surface that is opposite to that first surface; a set of non-transcending gaps within the semiconductor wafer. Each non-transcending gap penetrates from the first surface towards the second surface but reaches to a depth of between 80 to 99 percent of the thickness of the semiconductor wafer, and does not reach said second surface. Each non-transcending gap does not entirely penetrate through an entirety of the thickness of the semiconductor wafer. The semiconductor wafer maintains at least 1 percent of the thickness of the semiconductor wafer as an intact and non-penetrated thin layer of semiconductor wafer that remains intact and non-penetrated by the non-transcending gaps. The intact and non-penetrated thin layer of semiconductor wafer absorbs and dissipates mechanical forces.

Abstract: A method of preparing a composition for use as a cathode that combines two different cathode materials is disclosed. When utilized in a battery, one cathode material is rechargeable, and the second cathode material has a high capacity with a lower voltage than the first cathode material. The active materials may be combined in several fashions including mixing, layering, deposition, coating, and/or patterning. Such batteries can be tested repeatedly over a specific voltage range and provide high capacity under full discharge at deployment.

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: Document difference viewing and navigation are disclosed that enables automatic comparison and easy viewing of the difference between many documents (e.g., four or more, dozens, hundreds, or thousands of documents) for, for example, document review processes. The system receives and reads a set of documents containing text. The system identifies shared text and differences by location within the shared text among different documents in the set of documents. It sorts the documents in the set of documents into groups of different text variation versions and generates a shared difference document. The shared difference document is displayed in a first panel of a user interface and displays shared text as static text and areas of difference in highlighted regions. When a user selects of a given area of difference, the text variations and a list of documents containing one or more corresponding text variations are displayed in a second panel.

Abstract: The present disclosure relates to a method for automated characterisation of images obtained using a medical imaging modality, in particular, the present disclosure relates to a method for analysis of cine cardiac magnetic resonance (CMR) images using an artificial intelligence (AI) framework.

Abstract: A dental composition including calcium silicate, calcium carbonate, and at least one pozzolanic material, which is useful to prepare a hardened dental material with improved properties. Also, a kit including the dental composition for preparing a hardened dental material, to a medical device including the kit and to the use of the hardened dental material for treating the crown of a tooth and/or the root of a tooth.