Patents by Inventor Esther C.H. UIJTTEWAAL

Esther C.H. UIJTTEWAAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERNAL STANDARD FOR CRISPR GUIDE RNA
    Publication number: 20230121309
    Abstract: A nucleic acid including a sequence encoding a single guide RNA (sgRNA) of a CRISPR/Cas system is disclosed, wherein the sgRNA sequence is interrupted by a guide disruption sequence flanked by a first pair of recombinase recognition sites, and wherein the sgRNA sequence further includes a second pair of recombinase recognition sites that has a different recombinase recognition sequence than the first pair of recombinase recognition sites, wherein the guide disruption sequence is not flanked by the second pair of recombinase recognition sites and wherein the sequences flanked by the first and second recombinase recognition sites overlap; methods of using such a sgRNA, transgenic cells and kits.
    Type: Application
    Filed: March 30, 2021
    Publication date: April 20, 2023
    Inventors: Ulrich ELLING, Annika SELL, Esther C.H. UIJTTEWAAL