Abstract: There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).

Abstract: There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).

Abstract: There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

Abstract: The present invention relates to an instrument for marking and environmental monitoring in regatta courses. Incorporated by inflatable pneumatic platform and modular mast, foldable and transportable in compact packing of reduced size. It is intended to simultaneously define the area of conducting such nautical trials, at the same time as the environmental conditions thereof are characterized, in both meteorological and oceanographic terms. The system comprises an inflatable pneumatic float (1) and a support structure—mast—(2), which serves to hold the meteorological (3) and oceanographic (6) instrumentation, as well as the group of elements intended for communications (4), electromechanical components (5) and anchorage system (7). The marked modular level and reduced weight thereof, allow handling from craft of reduced cargo-carrying capacity without the help of additional infrastructures, which has a close relationship with the degree of variability in the regatta courses when competitions are under way.

Abstract: A sun visor for motor vehicles consisting of a structural frame (5) formed by a recyclable plastic material injected into a mould, and a second material, also recyclable, which is compatible with the material used in the frame and which incorporates certain components of the final sun visor unit.