Patents by Inventor Esther Martinborough

Esther Martinborough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives for modulation of ion channels
    Patent number: 7842819
    Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: November 30, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Zimmermann, Corey Don Gutierrez
  • Pyrimidines useful as modulators of voltage-gated ion channels
    Patent number: 7816529
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: October 19, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Mitchell Wilson, Esther Martinborough, Timothy Donald Neubert, Andreas Peter Termin, Jesus E. Gonzalez, III, Nicole Zimmerman
  • 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
    Patent number: 7816372
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: October 19, 2010
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Esther Martinborough, Yixing Shen, Thomas Lot Stevens Lau, Min Wu, Yun Oliver Long
  • Phenyl sulfonamides as modulators of ion channels
    Patent number: 7799822
    Abstract: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: September 21, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Lev T. D. Fanning, Urvi Sheth, Dean Wilson, Andreas Termin, Timothy Neubert, Nicole Zimmermann, Tara Knoll, Tara Whitney, Aarti Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Gutierrez
  • Bicyclic derivatives as modulators of ion channels
    Patent number: 7786137
    Abstract: Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Aarti S. Kawatkar, Tara M. Whitney, Timothy D. Neubert, Nicole Zimmermann, Andreas Termin, Esther Martinborough
  • BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
    Publication number: 20100204255
    Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: April 16, 2010
    Publication date: August 12, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Andreas Termin, Nicole Zimmermann, Tara Leanne Knoll, Gabriel Martinez-Botella, Esther Martinborough
  • Ion channel modulators and methods of use
    Patent number: 7767680
    Abstract: In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: August 3, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Nicole Zimmermann, Robert B. Perni, Michael Arnost, Upul K. Bandarage, Francois Maltais, Guy Bemis
  • Ion Channel Modulators and Methods of Uses
    Publication number: 20100184753
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 22, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Nicole Zimmermann, Robert B. Perni, Michael Arnost, Upul Bandarage, Francois Maltais, Guy Bemis
  • Bicyclic derivatives as modulators of ion channels
    Patent number: 7745629
    Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 29, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas Termin, Nicole Zimmermann, Tara Leanne Knoll, Gabriel Martinez-Botella, Esther Martinborough
  • QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS
    Publication number: 20100160316
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 24, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • BIPHENYL DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS
    Publication number: 20100130548
    Abstract: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Application
    Filed: February 1, 2010
    Publication date: May 27, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Martinborough, Danielle Lehsten, Timothy Neubert, Aarti Sameer Kawatkar, Nicole Zimmermann, Andreas Termin
  • Quinazolines useful as modulators of ion channels
    Patent number: 7713983
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: May 11, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Patent number: 7696246
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: April 13, 2010
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Esther Martinborough
  • Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
    Publication number: 20100087479
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 10, 2009
    Publication date: April 8, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Biphenyl derivatives as modulators of voltage gated ion channels
    Patent number: 7683083
    Abstract: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: March 23, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Danielle Lehsten, Timothy Neubert, Aarti Sameer Kawatkar, Nicole Zimmermann, Andreas Termin
  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Publication number: 20100069379
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 18, 2010
    Inventors: Lin Zhi, Christopher Tegley, Barbara Pio, Corneils Arjan Van Oeveren, Mehrnouch Motamedi, Esther Martinborough, Robert Higuchi, Lawrence G. Hamann
  • Quinazolines useful as modulators of ion channels
    Patent number: 7678802
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Indane Derivatives as Modulators of ION Channels
    Publication number: 20090326023
    Abstract: The present invention relates to indane derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: August 31, 2009
    Publication date: December 31, 2009
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Timothy Neubert, Aarti S. Kawatkar, Esther Martinborough, Andreas Termin
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 7615563
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: November 10, 2009
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Indane derivatives as modulators of ion channels
    Patent number: 7605174
    Abstract: The present invention relates to indane derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: October 20, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Neubert, Aarti S. Kawatkar, Esther Martinborough, Andreas Termin