Patents by Inventor Eszter Cholnoky

Eszter Cholnoky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and use
    Patent number: 4755510
    Abstract: The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings.The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: July 5, 1988
    Assignees: Richter Gedeon Vegyeszeti Gyar R.T., MTA Kozponti Kemiai Kutatointezete
    Inventors: Csilla Vezert nee Solyom, Laszlo rogdi, Lajos Kisfaludy, Laszlo Otvos, Zsuzsanna Tegyey, Helga Tudos nee Feuer, Eva Palosi, Sara Ronai nee Lukacs, Eszter Cholnoky, Laszlo Szporny
  • Certain 3- or 4-benzoyl-2-[(2-aminoethyl)thio-pyridines] and their anti-ulcer properties
    Patent number: 4713388
    Abstract: The invention relates to new 2-pyridine-thiol derivatives of the formula (I), ##STR1## wherein R is hydrogen or alkyl having from 1 to 4 carbon atoms,Z is phenyl optionally substituted by one or more halogen atoms and/or alkyl groups having from 1 to 4 carbon atoms,R.sup.1 and R.sup.2 each independently represents hydrogen, alkyl having from 1 to 4 carbon atoms, alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an ##STR2## group, in which R has the same meaning as defined above, and the substituent ##STR3## is attached to the pyridine ring in the position 3 or 4, with the proviso that if R.sup.1 and R.sup.2 are both methyl and Z is 4-chlorophenyl, R is other than hydrogen, and acid addition salts thereof.The invention further relates to processes for the preparation of the above compounds and to pharmaceutical compositions containing them as active ingredient.The compounds are pharmaceutically active, in particular show cytoprotective activity.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: December 15, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka V. Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Csaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas, Anna Kallay
  • 2-hydroxy-and 2-halo-ethylthiopyridine intermediates for preparing antiulcer compounds
    Patent number: 4691017
    Abstract: New intermediate compounds of the formula (I) are disclosed ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.4 alkyl;Z is phenyl optionally substituted by one or more halogen atoms and/or alkyl groups having 1 to 4 carbon atoms; andD is hydroxy, mesyloxy, p-tosyloxy, or halogen; or pharmaceutically acceptable acid addition salt thereof. The compounds of the Formula (I) are intermediates in the preparation of new compounds having anti-ulcer activity.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: September 1, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka Vikar nee Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Osaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas nee Pap, Anna Kallay nee Sohonyai
  • N-{2-[(3-benzoyl-2-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea, and use as anti-ulcer agents
    Patent number: 4624959
    Abstract: The compound N-{2-[(3-benzoyl-1-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea and pharmaceutically acceptable acid addition salts thereof are disclosed as well as pharmaceutical compositions containing same and a method of treatment employing same. The compound or its acid addition salts are effective in treating gastric oedema and thus are useful in ulcer therapy.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: November 25, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka Vikar nee Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Csaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas nee Pap, Anna Kallay nee Sohonyai
  • Treating mammalian subject sensitive to indomethacin ulcerogenisis
    Patent number: 4200631
    Abstract: Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of indomethacin by using it in a composition of 1 part of indomethacin to 7.5 to 25 parts, preferably 10 parts by weight of a salicylate. Indomethacin is the most potent ulcerating compound among approved non-steroid antiinflammatory agents.
    Type: Grant
    Filed: August 8, 1978
    Date of Patent: April 29, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Laszlo Szporny, Lilla Forgach, Eva Palosi, Eszter Cholnoky, Egon Karpati, Gyorgy Hajos, Gyozo Hortobagyi, Katalin Gidai
  • Antiphlogistic composition of phenylbutozone and alkali salicylate and method of treatment
    Patent number: 4198402
    Abstract: Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of phenylbutazone by using it in a composition of 1 part of antiphlogistic to 0.2 to 50 parts by weight of alkali metal salicylate.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: April 15, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Laszio Szporny, Lilla Forgach, Eva Palosi, Eszter Cholnoky, Egon Karpati, Gyorgy Hajos, Gyozo Hortobagyi, Katalin Gidai