Patents by Inventor Etai Yaffe

Etai Yaffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1YL) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-B][1,3,4]thiadiazole derivatives and their use
    Patent number: 8653082
    Abstract: Heterocyclic compounds of formula (I), (II), (III) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are each independently selected from hydrogen, halogen, C1-6alkyl, C2-6alkenyl, N—(C1-6alkyl)2, and N—(C2-6alkenyl)2, the C1-6alkyl and C2-6alkenyl being straight or branched; and Y1 and Y2 are selected from N and CH where one of Y1 and Y2 is N and the other is CH, are provided. Also provided are the synthesis of and pharmaceutical compositions including these compounds. These compounds and pharmaceutical compositions thereof can be used for the treatment of disorders, and in particular, cancer.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: February 18, 2014
    Assignee: Urifer Ltd.
    Inventors: Uri Nir, Sally Shpungin, Etai Yaffe, Moshe Cohen
  • Pharmaceutical compositions and methods for the treatment of cancer
    Patent number: 8481572
    Abstract: Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.
    Type: Grant
    Filed: August 10, 2008
    Date of Patent: July 9, 2013
    Assignee: Urifer Ltd.
    Inventors: Uri Nir, Sally Shpungin, Etai Yaffe, Moshe Cohen
  • 6-PHENYL-2-[((PIPERIDIN-4-YLMETHYL)-PIPERAZIN-1YL) OR PIPERAZIN 1-YLMETHYL)-PIPERIDIN-1-YL)]-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES AND THEIR USE
    Publication number: 20110306619
    Abstract: Provided are heterocyclic compounds, their synthesis and pharmaceutical compositions including them for the treatment of disorders, in particular, cancer.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 15, 2011
    Applicant: URIFER LTD.
    Inventors: Uri Nir, Sally Shpungin, Etai Yaffe, Moshe Cohen
  • PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20110086861
    Abstract: Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.
    Type: Application
    Filed: August 10, 2008
    Publication date: April 14, 2011
    Applicant: URIFER LTD
    Inventors: Uri Nir, Sally Shpungin, Etai Yaffe, Moshe Cohen
  • Methods and Systems for Searching for Regulators of the Fer Protein and for Monitoring the Effects of the Fer Protein
    Publication number: 20100151452
    Abstract: A method for modulating a Fer mediated pathway in a cell, for monitoring the effect of a Fer protein in a cell, for altering and inhibiting one or more effects of a Fer protein in a cell is provided. The method includes modulating, monitoring, altering or inhibiting any one or more or of the association of the Fer protein to PP1; the phosphorylation of PP1, the phosphatase activity of PP1, and the tumor suppressive activity of the retinoblastoma protein (RB). In a preferred embodiment, modulating a Fer mediated pathway in a cell, monitoring the effect of a Fer protein in a cell, for altering and inhibiting one or more effects of a Fer protein in a cell involves administrating to a cell a compound having a molecular weight of up to 1000 Dalton capable of modulating, altering or inhibiting an effect of Fer. Further provided is a method for determining whether a substance is capable of altering or inhibiting an effect of a Fer protein in a cell.
    Type: Application
    Filed: March 20, 2007
    Publication date: June 17, 2010
    Inventors: Uri Nir, Orel Pasder, Sally Shpungin, Etai Yaffe