Patents by Inventor Ethan Dmitrovsky

Ethan Dmitrovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Autoimmune disorder treatment using RXR agonists
    Patent number: 10034845
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: July 31, 2018
    Assignee: lo Therapeutics, Inc.
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS
    Publication number: 20180116985
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 3, 2018
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Autoimmune Disorder Treatment using RXR Agonists
    Publication number: 20170056348
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Application
    Filed: November 2, 2016
    Publication date: March 2, 2017
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Autoimmune Disorder Treatment Using RXR Agonists
    Publication number: 20150342917
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Application
    Filed: June 5, 2015
    Publication date: December 3, 2015
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Autoimmune Disorder Treatment Using RXR Agonists
    Publication number: 20150196517
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Application
    Filed: February 19, 2015
    Publication date: July 16, 2015
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 9056135
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: June 16, 2015
    Assignees: Trustees of Dartmouth College, Koebenhavns Universitet (University of Copenhagen)
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo F. Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Treatment of Diseases by Concurrently Eliciting Remyelination Effects and Immunomodulatory Effects Using Selective RXR Agonists
    Publication number: 20150038585
    Abstract: The present specification provides RXR agonists with both remyelination promotion and immunomodulatory activities, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat a demyelination-related disorder by both promoting remyelination of neurons and modulating the immune system.
    Type: Application
    Filed: October 6, 2014
    Publication date: February 5, 2015
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle, Martin E. Sanders
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG215 and/or UBP43
    Patent number: 8697668
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: April 15, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret C. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • microRNA Biomarkers for Human Breast and Lung Cancer
    Publication number: 20130296399
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 7, 2013
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo F. Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissue
    Patent number: 8417324
    Abstract: This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Mary-Ann Mycek, Ethan Dmitrovsky, Jonathan Pitts
  • Compositions and Methods for Preventing and Treating Cancer via Modulating UBE1L, ISG215 and/or UBP43
    Publication number: 20130041016
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Application
    Filed: September 17, 2012
    Publication date: February 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret C. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • METHOD FOR SELECTING A CANCER THERAPY
    Publication number: 20130005747
    Abstract: The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 3, 2013
    Applicants: Cyclacel Limited, The General Hospital Corporation d/b/a Massachusetts General Hospital, The Trustees of Dartmouth College
    Inventors: Simon Richard GREEN, Judy H. CHIAO, Jeffery SETTLEMAN, Ethan DMITROVSKY, Fabrizio Vittorio GALIMBERTI
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43
    Patent number: 8283113
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 9, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret A. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 8207325
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: June 26, 2012
    Assignees: Univ. of Copenhagen, Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation
    Patent number: 8124371
    Abstract: The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are agents identified in accordance with the screening method.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: February 28, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Sutisak Kitareewan, Roger Sloboda, Ethan Dmitrovsky
  • Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue
    Publication number: 20120041315
    Abstract: This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 16, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Mary-Ann Mycek, Ethan Dmitrovsky, Jonathan Pitts
  • Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissues
    Patent number: 8068898
    Abstract: This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: November 29, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Mary-Ann Mycek, Ethan Dmitrovsky, Jonathan Pitts
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 7955848
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: June 7, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCER
    Publication number: 20100010072
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Application
    Filed: May 6, 2009
    Publication date: January 14, 2010
    Applicants: Koebenhavns Universitet (University of Copenhagen), Trustees of Dartmouth College
    Inventors: Ethan DMITROVSKY, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Transgenic non-human animal model of lung tumorigenesis
    Patent number: 7586022
    Abstract: The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a lung-specific promoter. The transgenic animals of the present invention have elevated levels cyclin E protein in the lung and have in increased occurrence of lung carcinogenesis. The animals of the instant invention were also found to have increased levels of Gli1 and Shh. Vectors, cells and cell lines are provided, as is a method for identifying a therapeutic agent for the chemoprevention or treatment of lung cancer.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: September 8, 2009
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Yan Ma, Sarah J. Freemantle