Abstract: Embodiments of the instant application are directed to improved devices for sampling the gastrointestinal tract of a subject. In some embodiments, the device includes at least an ingestible capsule having 2 parts for housing an adjustable line or drag material having a least a proximal and distal segment. In some embodiments, the distal segment includes a multi-ply material capable of absorbing fluids and/or further including capture agents. In certain embodiments, the improved devices of the instant application include assessing a condition of the upper gastrointestinal tract of a subject including, but not limited to the esophagus and stomach of the subject.