Patents by Inventor Ethan Settembre

Ethan Settembre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11896636
    Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: February 13, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Andrew Geall, Ethan Settembre
  • Patent number: 11249088
    Abstract: The present application discloses stability-indicating potency assays for influenza vaccines.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: February 15, 2022
    Assignee: Seqirus UK Limited
    Inventors: Yingxia Wen, Ethan Settembre, Zihao Wang
  • Patent number: 11013795
    Abstract: Disclosed herein are influenza vaccine compositions, related preparations and intermediates, formulations, production methods, immunization methods, and use thereof, for achieving improved immune-protection in human subjects. More specifically, non-egg-based influenza vaccines are described, which provide improved antigenic match.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 25, 2021
    Assignee: Seqirus UK Limited
    Inventors: Ethan Settembre, Philip Dormitzer
  • Patent number: 10416171
    Abstract: The present application discloses stability-indicating potency assays for influenza vaccines.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: September 17, 2019
    Assignee: Seqirus UK Limited
    Inventors: Yingxia Wen, Ethan Settembre, Zihao Wang
  • Patent number: 10287324
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 14, 2019
    Assignee: NOVARTIS AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Patent number: 10192025
    Abstract: The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunizing a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: January 29, 2019
    Assignee: Novartis AG
    Inventors: Philip R. Dormitzer, Nikolaus Grigorieff, Stephen Harrison, Junhua Pan, Ethan Settembre
  • Publication number: 20190023746
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 24, 2019
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Patent number: 10065994
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 4, 2018
    Assignee: Novartis AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Patent number: 10030052
    Abstract: The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: July 24, 2018
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Ethan Settembre, Sumana Chandramouli
  • Patent number: 9744228
    Abstract: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: August 29, 2017
    Assignee: Norvartis AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Publication number: 20160222066
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain.
    Type: Application
    Filed: November 19, 2015
    Publication date: August 4, 2016
    Inventors: Ethan Settembre, Angelica MEDINA-SELBY, Doris COIT, Philip R. DORMITZER
  • Publication number: 20160188790
    Abstract: The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunising a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 30, 2016
    Inventors: Philip R. Dormitzer, Nikolaus Grigorieff, Stephen Harrison, Junhua Pan, Ethan Settembre
  • Publication number: 20140227346
    Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 14, 2014
    Inventors: Andrew Geall, Ethan Settembre
  • Publication number: 20140170187
    Abstract: The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
    Type: Application
    Filed: July 25, 2012
    Publication date: June 19, 2014
    Inventors: Ethan Settembre, Sumana Chandramouli
  • Publication number: 20130273109
    Abstract: The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 17, 2013
    Applicant: NOVARTIS AG
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
  • Publication number: 20130171185
    Abstract: The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
    Type: Application
    Filed: July 5, 2011
    Publication date: July 4, 2013
    Inventors: Ethan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer