Patents by Inventor Eti Kovalevski-Ishai
Eti Kovalevski-Ishai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10464957Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.Type: GrantFiled: August 16, 2017Date of Patent: November 5, 2019Assignee: VASCULAR BIOGENICS LTD.Inventors: Eti Kovalevski Ishai, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
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Patent number: 9968622Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: GrantFiled: February 13, 2017Date of Patent: May 15, 2018Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Publication number: 20170369516Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.Type: ApplicationFiled: August 16, 2017Publication date: December 28, 2017Inventors: Eti Kovalevski ISHAI, Itzhak MENDEL, Yaniv SALEM, Niva YACOV, Eyal BREITBART
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Patent number: 9771385Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.Type: GrantFiled: November 25, 2015Date of Patent: September 26, 2017Assignee: Vascular Biogenics Ltd.Inventors: Eti Kovalevski Ishai, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
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Publication number: 20170246197Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: ApplicationFiled: February 13, 2017Publication date: August 31, 2017Inventors: Gideon HALPERIN, Eti KOVALEVSKI-ISHAI
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Patent number: 9566288Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: GrantFiled: February 25, 2015Date of Patent: February 14, 2017Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Publication number: 20160304544Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.Type: ApplicationFiled: November 25, 2015Publication date: October 20, 2016Inventors: Eti Kovalevski ISHAI, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
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Patent number: 9206206Abstract: Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.Type: GrantFiled: November 5, 2009Date of Patent: December 8, 2015Assignee: Vascular Biogenics Ltd.Inventors: Eti Kovalevski-Ishai, Zeev Ziniuk, Gideon Halperin, Itzhak Mendel, Erez Feige, Niva Yacov, Eyal Breitbart
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Publication number: 20150216882Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: ApplicationFiled: February 25, 2015Publication date: August 6, 2015Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 9006217Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: GrantFiled: March 15, 2013Date of Patent: April 14, 2015Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8999960Abstract: Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: wherein X1, X2, A1, A2, B?, B?, D? and D? are as described herein.Type: GrantFiled: October 1, 2009Date of Patent: April 7, 2015Assignee: Vascular Biogenics Ltd.Inventors: Eyal Breitbart, Eti Kovalevski-Ishai, Erez Feige, Itzhak Mendel, Zeev Ziniuk, Gideon Halperin
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Patent number: 8802875Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: December 10, 2012Date of Patent: August 12, 2014Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8759557Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: March 12, 2013Date of Patent: June 24, 2014Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8569529Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: GrantFiled: November 9, 2012Date of Patent: October 29, 2013Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8563534Abstract: Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.Type: GrantFiled: March 27, 2012Date of Patent: October 22, 2013Assignee: Vascular Biogenics Ltd.Inventors: Dror Harats, Jacob George, Gideon Halperin, Niva Yacov, Eti Kovalevski-Ishai
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Publication number: 20130237720Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: ApplicationFiled: March 15, 2013Publication date: September 12, 2013Applicant: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8501715Abstract: Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.Type: GrantFiled: April 13, 2011Date of Patent: August 6, 2013Assignee: Vascular Biogenics Ltd.Inventors: Dror Harats, Jacob George, Gideon Halperin, Itzhak Mendel, Niva Yacov, Eti Kovalevski-Ishai
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Publication number: 20130079540Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4?-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).Type: ApplicationFiled: November 9, 2012Publication date: March 28, 2013Inventors: Gideon HALPERIN, Eti Kovalevski-Ishai
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Publication number: 20120329757Abstract: Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.Type: ApplicationFiled: March 27, 2012Publication date: December 27, 2012Inventors: Dror HARATS, Jacob George, Gideon Halperin, Niva Yacov, Eti Kovalevski-Ishai
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Publication number: 20120130108Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: ApplicationFiled: January 26, 2012Publication date: May 24, 2012Applicant: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai