Abstract: Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: A composition of matter comprising a DNAzyme molecule capable of mediating cleavage of p21 mRNA corresponding to SEQ ID NO: 1, wherein said DNAzyme molecule comprises a nucleic acid sequence at least 80% identical to the nucleic acid sequence set forth in any one of SEQ ID NOs: 23, 29, 33-38, 40, 42, 45-48, 53-60, 63-65, 69-74 or 78, is disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: A composition of matter comprising a DNAzyme molecule capable of mediating cleavage of p21 mRNA corresponding to SEQ ID NO: 1, wherein said DNAzyme molecule comprises a nucleic acid sequence at least 80% identical to the nucleic acid sequence set forth in any one of SEQ ID NOs: 23, 29, 33-38, 40, 42, 45-48, 53-60, 63-65, 69-74 or 78, is disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: In one aspect of the invention, provided herein an agricultural composition comprising a synergistically effective amount of a sulfide compound and of a surfactant. Further, a method of using the composition of the invention such as for enhancing or inducing bud break in a plant, is provided.

Abstract: A composition of matter comprising a DNAzyme molecule capable of mediating cleavage of p21 mRNA corresponding to SEQ ID NO: 1, wherein said DNAzyme molecule comprises a nucleic acid sequence at least 80% identical to the nucleic acid sequence set forth in any one of SEQ ID NOs: 23, 29, 33-38, 40, 42. 45-48. 53-60, 63-65, 69-74 or 78, is disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: A two-piece dispensing closure for dispensing essential oils includes an insert received into a container opening and a closure body including a dispensing spout and a hinged cap. The cap is connected to the closure body by a living hinge to allow the user to selectively open and close the container. A tamper-evident tear strip is integrally formed with the closure body. The insert and the closure body including mating helical ramps which cooperate to insure that the insert remains installed within the container neck when the closure body is removed after purchase.

Abstract: A method of generating human mature oligodendrocytes is disclosed. The method comprises contacting a cell population which comprises human pre-oligodendrocytes with an inhibitor of the MAPK/ERK pathway under conditions that allow the pre-oligodendrocytes to differentiate into mature oligodendrocytes. Use of the MAPK/ERK pathway inhibitor for treating diseases is also disclosed.

Abstract: Disclosed is a method of enhancing bud break in plants, comprising administering a combination of an amine polymer delivery agent and a sulfur containing compound to said plants. Disclosed also is a formulation comprising an amine polymer delivery agent and a sulfur containing compound. In addition, the use of such a formulation for enhancing bud break in plants is also disclosed.

Abstract: A two-piece dispensing closure for dispensing essential oils includes an insert received into a container opening and a closure body including a dispensing spout and a hinged cap. The cap is connected to the closure body by a living hinge to allow the user to selectively open and close the container. A tamper-evident tear strip is integrally formed with the closure body. The insert and the closure body including mating helical ramps which cooperate to insure that the insert remains installed within the container neck when the closure body is removed after purchase.

Abstract: Disclosed is a method of enhancing bud break in plants, comprising administering a combination of an amine polymer delivery agent and a sulfur containing compound to said plants. Disclosed also is a formulation comprising an amine polymer delivery agent and a sulfur containing compound. In addition, the use of such a formulation for enhancing bud break in plants is also disclosed.

Abstract: The present invention provides a system that is configured to operate as a platform which enables users to online purchase from a digital insurance-based company one or more products, e.g., such as an insurance policy, and accordingly to create for each purchased product a corresponding amount of digital currency.

Abstract: Disclosed is a method of enhancing bud break in plants, comprising administering a combination of an amine polymer delivery agent and a sulfur containing compound to said plants. Disclosed also is a formulation comprising an amine polymer delivery agent and a sulfur containing compound. In addition, the use of such a formulation for enhancing bud break in plants is also disclosed.

Abstract: Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving performance metrics from at least one device within the cloud network; analyzing the performance metrics to generate at least one application requirement, wherein the at least one application requirement indicates a recent performance associated with a resource provisioned for a customer, wherein the resource is supported by a first device within the cloud network; identifying a second device within the cloud network to support the resource based on the at least one application requirement; and migrating the resource from the first device to the second device.

Abstract: The present invention provides an inflatable device that floats on water having an inflatable body for flotation; and a built-in speaker unit being secured in a first compartment in the body. In addition, the first compartment and the speaker may be in the headrest, or armrest, or in a removable pillow. Further, the battery box is secured in a second compartment in the body, wherein the battery is rechargeable and the speaker unit is connected to the battery as a power source, or to a solar power source. The present invention also provides a flotation device that floats on water having a foam body for flotation; and a built-in speaker unit being secured in a first compartment in the body. In addition, the first compartment and the speaker may be in the headrest, or armrest, or in a removable pillow. Further, the battery box is secured in a second compartment in the body, wherein the battery is rechargeable and the speaker unit is connected to the battery as a power source, or to a solar power source.

Abstract: Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, from a requesting device, a request to establish a component of an application; identifying a policy file associated with the application, wherein the policy file defines at least one segment for the application and defines at least one constraint for a first segment of the at least one segment; selecting the first segment for establishment of the component; selecting a location for establishment of the component, wherein the location is selected to be consistent with the at least one constraint; and establishing the component at the selected location.

Abstract: A goal evaluation capability is provided. A resource allocation request of a customer is received. The resource allocation request includes a request for allocation of resources of a distributed system of a provider, a set of customer constraints, and a customer goal. A set of feasible resource allocations for the customer is determined based on the set of customer constraints and on information associated with the distributed system. The set of feasible resource allocations includes a plurality of feasible resource allocations. A provider goal function associated with a provider goal of the provider is determined. A customer goal function associated with the customer goal of the customer is determined. A feasible resource allocation is selected for the customer, from the set of feasible resource allocations, based on the provider goal function and the customer goal function.

Abstract: A client device requests permission from a network access device to access a network associated with the network access device. The client device sends credentials of a user associated with the client device for authenticating with the network access device. The client device receives from the network access device permission to access the network along with a session certificate and an associated key. The session certificate and the key are associated with the credentials of the user. The client device establishes a network session using the network based on receiving the permission. During the network session, the client device establishes a secure communications channel with a website. The client device authenticates the user to the website by sending the session certificate to the website over the secure communications channel. The client device then receives permission from the website to access contents of the website.

Abstract: Provided are systems and methods for providing human cell cultures. Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic cells cultures from stem cells, the somatic cell cultures being free of extraembryonic cells.

Abstract: Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving performance metrics from at least one device within the cloud network; analyzing the performance metrics to generate at least one application requirement, wherein the at least one application requirement indicates a recent performance associated with a resource provisioned for a customer, wherein the resource is supported by a first device within the cloud network; identifying a second device within the cloud network to support the resource based on the at least one application requirement; and migrating the resource from the first device to the second device.