Patents by Inventor Ettore Rastelli

Ettore Rastelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In-flow photooxygenation of aminothienopyridinones generates novel PTP4A3 phosphatase inhibitors
    Patent number: 12227515
    Abstract: The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: February 18, 2025
    Assignees: University of Virginia Patent Foundation, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: John S. Lazo, Elizabeth Sharlow, Peter Wipf, Nikhil Tasker, Ettore Rastelli
  • In-flow photooxygenation of aminothienopyridinones generates PTP4A3 phosphatase inhibitors
    Patent number: 12202839
    Abstract: The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: January 21, 2025
    Assignees: University of Virginia Patent Foundation, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: John S. Lazo, Elizabeth Sharlow, Peter Wipf, Nikhil Tasker, Ettore Rastelli
  • INHIBITORS OF NLRP3
    Publication number: 20240262806
    Abstract: The present invention relates to novel compounds of Formulae I-XI: wherein each A, A?, Q, Q?, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
    Type: Application
    Filed: August 24, 2022
    Publication date: August 8, 2024
    Applicant: PCT THERAPEUTICS, INC.
    Inventors: XIAOYAN ZHANG, TIANYI ZHENG, SCOTT j BARRAZA, LAUREN BEJCEK, BRADLEY B GILBERT, HUA GONG, HANDOKO HANDOKO, SEYEDMORTEZA HOSSEYNI, EDUARDO HUARTE, WOOHYUNG JEON, JING LI, YAO LIU, KYLE NIEDERER, MEENU PILLAI, ERICA N PARKER, ETTORE RASTELLI, NADIYA SYDORENKO, ANTHONY TURPOFF, MATTHEW G WOLL, NANJING ZHANG, YAN ZHANG, RAUFUL ALAM
  • IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS
    Publication number: 20220017534
    Abstract: The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 20, 2022
    Inventors: John S. Lazo, Elizabeth Sharlow, Peter Wipf, Nikhil Tasker, Ettore Rastelli
  • IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS
    Publication number: 20210395266
    Abstract: The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.
    Type: Application
    Filed: November 12, 2019
    Publication date: December 23, 2021
    Inventors: John S. Lazo, Elizabeth Sharlow, Peter Wipf, Nikhil Tasker, Ettore Rastelli