Abstract: A method for precursor production includes A) providing a multitude of container precursors, and in each case a) providing a sheet-like composite, having a first longitudinal edge, a further longitudinal edge and, from the first longitudinal edge to the further longitudinal edge: i. a first longitudinal crease, ii. a second longitudinal crease, iii. a third longitudinal crease, and iv. a fourth longitudinal crease. The method includes b) producing a first longitudinal fold characterized by a first internal angle along the first longitudinal crease and a third longitudinal fold characterized by a third internal angle along the third longitudinal crease; c) producing a second longitudinal fold characterized by a second internal angle along the second longitudinal crease and a fourth longitudinal fold characterized by a fourth internal angle along the fourth longitudinal crease; d) contacting and joining the first longitudinal edge to the further longitudinal edge thereby obtaining a longitudinal seam.

Abstract: The present invention relates to a method for purifying a target product in a flow-through chromatography system comprises at least a first column loaded with feed material from a feed source. The at least first column is purged after binding of impurities and wherein the outlet of purged material from the column is subsequently passed to the feed source.

Abstract: The present invention relates to a method for monitoring operational status in continuous chromatography configured to operate with at least three columns adapted for cyclic use for continuous purification of a target product when feeding the continuous chromatography with a sample containing the target product. The method comprises detecting (81) at least one parameter indicative of a selected function in the continuous chromatography, performing (82) real time trend analysis of the detected parameter to identify a deviating behaviour of the selected function, and initiate (83) actions to eliminate or reduce the effect of the identified deviating behaviour where by the performance of the continuous chromatography is maintained.

Abstract: The present invention relates to a method for controlling a bioprocess purification system comprising a continuous chromatography configured to operate with at least three columns and configured for cyclic operation, wherein the continuous purification is performed on a sample comprising a target product having desired characteristics. The method comprises detecting (82) at least one parameter indicative of characteristics of the target product, performing (83) real time trend analysis of each detected at least one parameter to identify a deviation from the desired characteristics of the target product, and controlling (84) the bioprocess purification system to meet the desired characteristics based on the identified deviation, whereby the target characteristics is within a pre-determined range.

Abstract: The invention relates to a method comprising, as method steps, A) providing a multitude of container precursors, in each case comprising: a) providing a sheetlike composite, wherein the sheetlike composite comprises a first longitudinal edge, a further longitudinal edge and, from the first longitudinal edge to the further longitudinal edge: i. a first longitudinal crease, ii. a second longitudinal crease, iii. a third longitudinal crease, and iv.