Patents by Inventor Eugen Merkul

Eugen Merkul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREPARING CELL TARGETING CONJUGATES AND CONJUGATES OBTAINABLE BY SAID METHODS
    Publication number: 20210113712
    Abstract: Methods for preparing a cell targeting conjugate, which conjugate comprises a cell binding moiety conjugated to a secondary functional moiety. The disclosure further relates to the cell targeting conjugates obtainable by the method, to a pharmaceutical composition comprising the conjugates and to the secondary functional moieties as such. The disclosure also relates to the use of the cell targeting conjugates in the treatment of cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: April 22, 2021
    Inventors: Eugen Merkul, Niels Jurriaan Sijbrandi, Joey Armand Muns, Augustinus Antonius Maria Silvester Van Dongen, Paulus Johannes Gerardus Maria Steverink, Hendrik Jan Houthoff
  • TRANSITION METAL-BASED FUNCTIONAL MOIETIES FOR PREPARING CELL TARGETING CONJUGATES
    Publication number: 20200345862
    Abstract: The disclosure relates to secondary functional moieties comprising a transition metal-based linker and a primary functional moiety bound thereto. The disclosure also relates to cell targeting conjugates comprising a linker of the invention. The disclosure further relates to a medicament comprising the cell targeting conjugate and to the use of the cell targeting conjugates in the diagnosis and treatment of cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: November 5, 2020
    Inventors: Eugen Merkul, Niels Jurriaan Sijbrandi, Joey Armand Muns, Augustinus Antonius Maria Silvester Van Dongen, Paulus Johannes Gerardus Maria Steverink, Hendrik Jan Houthoff
  • 7-azaindole derivatives
    Patent number: 9725446
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: August 8, 2017
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J. J. Mueller, Eugen Merkul, Gnuni Amatunu Karapetyan
  • 7-AZAINDOLE DERIVATIVES
    Publication number: 20160130269
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Application
    Filed: January 5, 2016
    Publication date: May 12, 2016
    Applicant: MERCK PATENT GmbH
    Inventors: Dieter DORSCH, Christian SIRRENBERG, Thomas J.J. MUELLER, Eugen MERKUL, Gnuni Amatunu KARAPETYAN
  • 7-azaindole derivatives
    Patent number: 9266887
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: February 23, 2016
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J. J. Mueller, Eugen Merkul, Gnuni Amatunu Karapetyan
  • 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives
    Patent number: 9079910
    Abstract: Compounds of the formula (I), in which R1, R2, R2a and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: July 14, 2015
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J. J. Mueller, Eugen Merkul
  • 7-AZAINDOLE DERIVATIVES
    Publication number: 20150152104
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 4, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Christian SIRRENBERG, Thomas J.J. MUELLER, Eugen MERKUL, Gnuni Amatunu KARAPETYAN
  • 7-azaindole derivatives
    Patent number: 8981101
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 17, 2015
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J. J. Mueller, Eugen Merkul, Gnuni Amatunu Karapetyan
  • Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines
    Patent number: 8865715
    Abstract: The invention relates to compounds the formula (I): and pharmaceutically usable salts, tautomers and stereoisomers thereof, wherein R1, R2 and R3 are defined herein. The compounds of formula (I) and their pharmaceutically usable salts, tautomers and stereoisomers are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: October 21, 2014
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J. J. Mueller, Eugen Merkul
  • 7-AZAINDOLE DERIVATIVES
    Publication number: 20130310391
    Abstract: Compounds of the formula (I) in which R, R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: January 9, 2012
    Publication date: November 21, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J.J. Mueller, Eugen Merkul, Gnuni Amatunu Karapetyan
  • 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20130289017
    Abstract: Compounds of the formula (I), in which R1, R2, R2a and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 31, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J.J. Mueller, Eugen Merkul
  • 4 (pyrrolopyridinyl)pyrimidin-2-ylamine derivatives
    Patent number: 8557977
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of cell proliferation\cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: October 15, 2013
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Christian Sirenberg, Thomas J. J. Mueller, Eugen Merkul
  • 6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and AIDS
    Patent number: 8546390
    Abstract: Compounds of the formula (I), in which R1, R2, R3 and R4 have the meanings indicated in claim (1), are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: October 1, 2013
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Lars T. Burgdorf, Christian Sirrenberg, Christina Esdar, Thomas J. J. Mueller, Eugen Merkul
  • 3-(1,2,3-triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives
    Patent number: 8541584
    Abstract: Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim (1), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: September 24, 2013
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J. J. Mueller, Eugen Merkul
  • 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES
    Publication number: 20130217951
    Abstract: Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: October 12, 2011
    Publication date: August 22, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J.J. Mueller, Eugen Merkul
  • 4 (pyrrolopyridinyl)pyrimidin-2-ylamine derivatives
    Patent number: 8293891
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: October 23, 2012
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J. J. Mueller, Eugen Merkul
  • 4 (PYRROLOPYRIDINYL)PYRIMIDIN-2-YLAMINE DERIVATIVES
    Publication number: 20120264999
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in claim 1, are inhibitors of cell proliferation/|cell vitality and can be employed for the treatment of tumours
    Type: Application
    Filed: June 19, 2012
    Publication date: October 18, 2012
    Applicant: Merck Patent Gesellschaft
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J.J Mueller, Eugen Merkul
  • 3-(1,2,3-Triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives
    Publication number: 20120053178
    Abstract: Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim (1), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: April 8, 2010
    Publication date: March 1, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Thomas J.J. Mueller, Eugen Merkul
  • 4 (Pyrrolopyridinyl)pyrimidin-2-ylamine derivatives
    Publication number: 20110092527
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours
    Type: Application
    Filed: January 28, 2008
    Publication date: April 21, 2011
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventors: Dieter Dorsch, Christian Sirrenberg, Thomas J.J. Mueller, Eugen Merkul
  • 6-(PYRROLOPYRIDINYL) PYRIMIDIN-2-YLAMINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER AND AIDS.
    Publication number: 20110082140
    Abstract: Compounds of the formula (I), in which R1, R2, R3 and R4 have the meanings indicated in claim (1), are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
    Type: Application
    Filed: May 23, 2008
    Publication date: April 7, 2011
    Applicant: Merck Patent GmbH
    Inventors: Dieter Dorsch, Margarita Wucherer-Plietker, Lars Thore Burgdorf, Christian Sirrenberg, Christina Esdar, Thomas J.J. Mueller, Eugen Merkul