Abstract: A fluid coupling has two similar coupling halves, each with a rotary body of a valve. A drive device for closing/opening the valve is associated with each rotary body. Each half has a coupling means for connecting/decoupling the halves by relative rotation. Securing means secure the connection when at least one valve is open and close the two rotary valves to disconnect/connect the halves. The drive device is arranged on one half and has a drive shaft which is associated with a valve shaft of the rotary body of the other half. A locking connection is configured which, when the halves are connected, connects the drive shaft on one half to the valve shaft on the other in a non-rotatable/releasable manner such that the rotation of the rotary body is controllable and relative rotation of the halves is blocked but the relative rotation when the valves are closed is permitted.

Abstract: A system and method detect neuronal action potential signals from tissue responding to electrical stimulation signals. A sparse signal space model for a set of tissue response recordings has a signal space separable into a plurality of disjoint component manifolds including a neural action potential (NAP) component manifold corresponding to tissue response to electrical stimulation signals. A response measurement module is configured to: i. map a tissue response measurement signal into the sparse signal model space to obtain a corresponding sparse signal representation, ii. project the sparse signal representation onto the NAP component manifold to obtain a sparse NAP component representation, iii. when the sparse NAP component representation is greater than a minimum threshold value, report and recover a detected NAP signal in the tissue response measurement signal.

Abstract: A fluid coupling has two similar coupling halves, each with a rotary body of a valve. A drive device for closing/opening the valve is associated with each rotary body. Each half has a coupling means for connecting/decoupling the halves by relative rotation. Securing means secure the connection when at least one valve is open and close the two rotary valves to disconnect/connect the halves. The drive device is arranged on one half and has a drive shaft which is associated with a valve shaft of the rotary body of the other half. A locking connection is configured which, when the halves are connected, connects the drive shaft on one half to the valve shaft on the other in a non-rotatable/releasable manner such that the rotation of the rotary body is controllable and relative rotation of the halves is blocked but the relative rotation when the valves are closed is permitted.

Abstract: A hearing implant fitting system includes a physiological database containing physiological data characterizing auditory neural tissue response to electrical stimulation. A neural action potential (NAP) measurement system measures NAP signals from cochlear tissue responding to electrical stimulation signals delivered by one or more of the electrode contacts, including: deriving a compound discharge latency distribution (CDLD) of the cochlear tissue by deconvolving: (1) a tissue response measurement signal taken responsive to the delivered electrical stimulation signals, with (2) an elementary unit response signal representing voltage change at a measurement electrode contact due to the electrical stimulation, and then comparing the CDLD to physiological data from the physiological database to detect an NAP signal from the tissue response measurement signal.

Abstract: A method of fitting a cochlear implant in an ipsilateral ear of a subject, the cochlear implant having an electrode array with one or more electrode contacts, includes applying broad-band white noise stimulus to a contralateral ear in order to mask efferent nerve fibers, applying a single pulse stimulus to the ipsilateral ear and then measuring base-line evoked compound action potential (CAP) signals in the ipsilateral ear for an electrode contact during a refractory period, applying a sequence of separated single pulse stimuli to the contralateral ear and then measuring attenuated CAP signals in the ipsilateral ear for the electrode contact during the refractory period, comparing the measured attenuated CAP signals to the measured base-line CAP signals in order to determine a CAP threshold for the electrode contact and adjusting processing parameters of the cochlear implant based on the CAP threshold.

Abstract: A system and method detect neuronal action potential signals from tissue responding to electrical stimulation signals. A sparse signal space model for a set of tissue response recordings has a signal space separable into a plurality of disjoint component manifolds including a neural action potential (NAP) component manifold corresponding to tissue response to electrical stimulation signals. A response measurement module is configured to: i. map a tissue response measurement signal into the sparse signal model space to obtain a corresponding sparse signal representation, ii. project the sparse signal representation onto the NAP component manifold to obtain a sparse NAP component representation, iii. when the sparse NAP component representation is greater than a minimum threshold value, report and recover a detected NAP signal in the tissue response measurement signal.

Abstract: The present invention relates to compositions comprising at least one lactose component, at least one cellulose component and at least one starch component, its preparation and its use, particularly as a direct tabletting excipient.

Abstract: A hearing implant fitting system includes a physiological database containing physiological data characterizing auditory neural tissue response to electrical stimulation. A neural action potential (NAP) measurement system measures NAP signals from cochlear tissue responding to electrical stimulation signals delivered by one or more of the electrode contacts, including: deriving a compound discharge latency distribution (CDLD) of the cochlear tissue by deconvolving: (1) a tissue response measurement signal taken responsive to the delivered electrical stimulation signals, with (2) an elementary unit response signal representing voltage change at a measurement electrode contact due to the electrical stimulation, and then comparing the CDLD to physiological data from the physiological database to detect an NAP signal from the tissue response measurement signal.

Abstract: A method of fitting a cochlear implant in an ipsilateral ear of a subject, the cochlear implant having an electrode array with one or more electrode contacts, includes applying broad-band white noise stimulus to a contralateral ear in order to mask efferent nerve fibers, applying a single pulse stimulus to the ipsilateral ear and then measuring base-line evoked compound action potential (CAP) signals in the ipsilateral ear for an electrode contact during a refractory period, applying a sequence of separated single pulse stimuli to the contralateral ear and then measuring attenuated CAP signals in the ipsilateral ear for the electrode contact during the refractory period, comparing the measured attenuated CAP signals to the measured base-line CAP signals in order to determine a CAP threshold for the electrode contact and adjusting processing parameters of the cochlear implant based on the CAP threshold.

Abstract: A system for frequency matching a cochlear implant during fitting includes a tissue stimulation device configured to generate a tonal stimulus to mask efferent nerve fibers in a subject, one or more response measurement contacts configured to measure CAP signals during and outside of a refractory period, a frequency matching module in communication with the response measurement contacts and configured to receive the CAP signals during and outside of the refractory period to determine a stimulation location on the cochlear implant based on a comparison of the received CAP signals both during and outside of the refractory period, and a parameter adjusting module in communication with the frequency matching module and configured to interface with the cochlear implant and to adjust its processing parameters based on the stimulation location. Methods for frequency matching a cochlear implant during fitting are also disclosed.

Abstract: The present invention relates to compositions comprising at least one lactose component, at least one cellulose component and at least one starch component, its preparation and its use, particularly as a direct tabletting excipient.

Abstract: A system for frequency matching a cochlear implant during fitting includes a tissue stimulation device configured to generate a tonal stimulus to mask efferent nerve fibers in a subject, one or more response measurement contacts configured to measure CAP signals during and outside of a refractory period, a frequency matching module in communication with the response measurement contacts and configured to receive the CAP signals during and outside of the refractory period to determine a stimulation location on the cochlear implant based on a comparison of the received CAP signals both during and outside of the refractory period, and a parameter adjusting module in communication with the frequency matching module and configured to interface with the cochlear implant and to adjust its processing parameters based on the stimulation location. Methods for frequency matching a cochlear implant during fitting are also disclosed.

Abstract: The present invention relates to the isolation of novel glucan particles but also to mannoprotein from natural sources such as yeast cell walls, novel isolation methods, and the use of products thereof.

Abstract: The present invention relates to a process for the preparation of directly compressible mannitol having a content of the ? modification of greater than 90%.

Abstract: The present invention concerns a process for producing a granulate based on lactose and cellulose (derivative), a granulate obtainable by the process and its use as a tabletting excipient.

Abstract: The present invention relates to a process for the preparation of directly compressible mannitol having a content of the ? modification of greater than 90%.

Abstract: The present invention concerns a process for producing a granulate based on lactose and cellulose (derivative), a granulate obtainable by the process and its use as a tabletting excipient.

Abstract: The present invention relates to the isolation of novel glucan particles but also to mannoprotein from natural sources such as yeast cell walls, novel isolation methods, and the use of products thereof.

Abstract: The invention relates to directly compressible tabletting aids with a xylitol content of more than 90% by weight and a content of at least one other polyol of less than 10% by weight, which are produced by co-spray drying or co-fluidized bed granulation. The invention further relates to compositions, formulations and solid forms or compacts which comprise a tabletting aid according to the invention, and to a process for producing the tabletting aids according to the invention.

Abstract: The invention can relate to a fluidized bed apparatus with an integrated spray-drying device and to a method for using the same. The invention also can relate to a method for producing a spray-dried powder material, whose product characteristics can be specifically adapted according to the ulterior use of the material.