Patents by Inventor Eugene A. Mash

Eugene A. Mash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12226488
    Abstract: The present invention provides a nitroreductase-releasable pro-drug of the formula: where Ar1, m, n, Z, Y, L, and A are as defined herein, and methods for using and producing the same. Compound of formula I is useful in oral administration of the active pharmaceutical ingredient to the distal gut region of a subject to treat a wide variety of clinical conditions associated with distal gut region of a subject, such as colorectal cancer, inflammatory bowel disease (IBD), infectious diarrhea, bacterial infections, and bacterial overgrowth.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: February 18, 2025
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Eugene A. Mash, Pawel R. Kiela
  • Publication number: 20220211854
    Abstract: The present invention provides a nitroreductase-releasable pro-drug of the formula: where Ar1, m, n, Z, Y, L, and A are as defined herein, and methods for using and producing the same. Compound of formula I is useful in oral administration of the active pharmaceutical ingredient to the distal gut region of a subject to treat a wide variety of clinical conditions associated with distal gut region of a subject, such as colorectal cancer, inflammatory bowel disease (IBD), infectious diarrhea, bacterial infections, and bacterial overgrowth.
    Type: Application
    Filed: April 6, 2020
    Publication date: July 7, 2022
    Applicant: Arizona Board of Regents on Behalf of the University of Arizona, a body corporate
    Inventors: Eugene A. MASH, Pawel R. KIELA
  • Publication number: 20220001038
    Abstract: Disclosed are anti-cancer compounds and imaging agents. More specifically, the disclosed agents target carbonic anhydrase IX and XII and their use in the treatment of cancer, in particular breast cancer. Specific compounds are those that have Formula II wherein R1 and R2 are each independently chosen from (CH2)nC?CH and, L is a linking moiety; n is 1-8; m is 0-8; each X is independently chosen from R3, OR3, NH2, NHR3, and; and each R3 is independently chosen from a detectable moiety or targeting moiety, with the proviso that R1 and R2 are not both (CH2)4C?CH.
    Type: Application
    Filed: June 21, 2018
    Publication date: January 6, 2022
    Inventors: David L. Morse, Eugene A. Mash, M. Catherine Lee
  • Patent number: 11207429
    Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: December 28, 2021
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Eugene A. Mash, Parastou Foroutan, Suryakiran Navath, Robert J. Gillies, Gary V. Martinez, David L. Morse
  • Publication number: 20170209602
    Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.
    Type: Application
    Filed: May 11, 2015
    Publication date: July 27, 2017
    Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, H. Lee Moffitt Cancer Center and Research Institute
    Inventors: Eugene A. Mash, Parastou Foroutan, Navath Suryakiran, Robert J. Gillies, Gary V. Martinez, David L. Morse
  • Publication number: 20160346399
    Abstract: The present invention provides a composition comprising a disaccharide where at least one of the hydroxyl groups of the disaccharide is attached to a linker. The terminal portion of the linker also includes a drug that is attached via a functional group that is capable of releasing the drug in vivo. Compositions of the invention are useful for delivering the drug at or near inter alia lower GI tract. In some embodiments, compositions of the invention are used for, but not limited to, treating diseases of the colon, and in particular, inflammatory bowel disease, microscopic colitis, and eosinophilic colitis.
    Type: Application
    Filed: August 10, 2016
    Publication date: December 1, 2016
    Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Eugene A. Mash, Pawel R. Kiela, Fayez K. Ghishan
  • Patent number: 9415110
    Abstract: A composition and method for targeted delivery of substances to the lower GI tract comprises a base or scaffold carrier to which a drug or prodrug is fixed or covalently attached. Compound, when taken orally travels through the GI tract of a patient to the lower GI where bacterial azo reductace enzymes cleave the bonds, releasing the drug or prodrug from the base or scaffold carrier permitting the delivery of the drug to the vicinity of a target cell type in the GI tract. The base or scaffold, which remains as a by-product passes out of the GI tract in the feces.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: August 16, 2016
    Assignee: The Arizona Board of Regents on behalf of the Univeristy of Arizona
    Inventors: Eugene A. Mash, Jr., Pawel R. Kiela, Fayez K. Ghishan
  • Patent number: 9320734
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: April 26, 2016
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • Publication number: 20150126563
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Application
    Filed: January 5, 2015
    Publication date: May 7, 2015
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka MAHADEVAN, Emmanuelle J. MEUILLET, Eugene A. MASH, JR., Vijay M. GOKHALE, Garth POWIS, Shuxing ZHANG
  • Patent number: 8962663
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 24, 2015
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • Patent number: 8420678
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: April 16, 2013
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gohkale, Garth Powis, Shuxing Zhang
  • Publication number: 20110144066
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 16, 2011
    Applicants: The Board of Regents of the University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Vijay Gokhale, Garth Powis, Shuxing Zhang