Abstract: Systems and methods are described in which proteins are isolated from complex solutions in high yield and at high purity. Such systems and methods are carried out at ambient temperature and can be carried out at industrial scale with minimal energy requirements and minimal carbon footprint, using successive chromatographic separations that retain the protein or proteins of interest in flow-through fractions. At least one of the chromatography media used is selected to be capable of interacting with both contaminants and the protein of interest, however capacity of this media is selected such that the protein of interest is displaced and remains in the flow-through. Methods for isolation of IgG, albumin, and both IgG and albumin are provided.

Abstract: Systems are provided for isolation of a protein, such as immunoglobulin G (IgG), from plasma, where the protein is initially fractioned by salt precipitation, followed by successive ion exchange steps in which the protein appears in unbound, flow-through fractions of the ion exchange steps. Some embodiments employ successive anion exchange steps. Other embodiments employ an anion exchange step followed by application of flow-through of the anion exchange step to a cation exchange step, with the protein collected in flow-through fractions from the cation exchange step. IgG is collected at high yield (typically about 75% or greater) and high purity. Avoidance of binding and elution from chromatography media simplifies processing and scale up without sacrificing IgG quality or yield.

Abstract: Methods and system for automating conferencing in a communication session are provided herein. In some embodiments, a method for automating conferencing in a communication session includes establishing a communication session between a first end-user device and a second end-user device; receiving a first notification message from the first end-user device indicating that the communication session is at least one of visible or joinable by one or more devices associated with the first end-user device, wherein the one or more devices are associated with the first end-user device when the one or more devices are one of (i) pre-registered and stored with an association to the first end-user device, (ii) pre-authenticated to tether the one or more devices to the first end-user device, or (iii) pre-associated with a same user account profile; and sending a second notification message to the one or more devices associated with the first end-user device.

Abstract: A respiration gas monitor device (100) includes a pump (110) connected to draw a flow of respired air, a pressure sensor (150, 160) is connected to measure an air pressure signal responsive to the flow of respired air, and a pressure transducer (180c). Electrical circuitry (170, 180) is operatively connected to measure flow across the pressure sensor. A gas component sensor (190, 192, 194) is arranged to monitor a target gas in the flow of respired air.

Abstract: An IP telephony system allows a user to register a telephony device that receives its native telephony service from a different telephony service provider as an extension telephone. The user can then place calls through the IP telephony system using the extension telephone. Such calls may or may not be established using the extension telephone's native telephony service provider.

Abstract: Methods and system for automating conferencing in a communication session are provided herein. In some embodiments, a method for automating conferencing in a communication session includes establishing a communication session between a first end-user device and a second end-user device; receiving a first notification message from the first end-user device indicating that the communication session is at least one of visible or joinable by one or more devices associated with the first end-user device, wherein the one or more devices are associated with the first end-user device when the one or more devices are one of (i) pre-registered and stored with an association to the first end-user device, (ii) pre-authenticated to tether the one or more devices to the first end-user device, or (iii) pre-associated with a same user account profile; and sending a second notification message to the one or more devices associated with the first end-user device.

Abstract: A respiration gas monitor (RGM) device includes an infrared light source (30) launching infrared light (34) through a respired air flow path (36), and an optical detector (40) that detects the infrared light after passing through the respired air flow path. An absorption line bandpass filter (42) has a passband encompassing an absorption line of a target gas. A reference line bandpass filter (44) has a passband over which the respired air is transparent. A control device (62, 64, 70, 80, 90) switches the RGM device between: a monitoring state in which the absorption line bandpass filter is in the path of the infrared light; and a calibration state in which the reference line bandpass filter is in the path of the infrared light and the absorption line bandpass filter is not in the path of the infrared light.

Abstract: An IP telephony system allows a user to register a telephony device that receives its native telephony service from a different telephony service provider as an extension telephone. The user can then place calls through the IP telephony system using the extension telephone. Such calls may or may not be established using the extension telephone's native telephony service provider.

Abstract: A target gas sensor employing a radiation source (20) and a radiation sensor (30) including a reference radiation detector (31), a target radiation detector (32), a temperature sensor (34), a temperature controller (35) and a target gas detection processor (37). In operation, radiation source (20) controls a propagation of radiation (RAD) through a gas mixture (GM) contained by an airway (10) to radiation sensor (30). Reference radiation detector (31) generates a reference detection signal (RD) indicative of a detected magnitude of a reference wavelength (?REF) of the radiation, and target radiation detector (32) generates a target detection signal (TD) indicative of a detected magnitude of a target wavelength (?TG) of the radiation. Temperature sensor (34) senses a temperature of radiation detectors (31, 32) whereby temperature controller (35) regulates a heating of the radiation detectors (31, 32) relative to a regulated detector temperature (TREG).

Abstract: A target gas sensor employing a radiation source (20) and a radiation sensor (30) including a reference radiation detector (31), a target radiation detector (32), a temperature sensor (34), a temperature controller (35) and a target gas detection processor (37). In operation, radiation source (20) controls a propagation of radiation (RAD) through a gas mixture (GM) contained by an airway (10) to radiation sensor (30). Reference radiation detector (31) generates a reference detection signal (RD) indicative of a detected magnitude of a reference wavelength (?REF) of the radiation, and target radiation detector (32) generates a target detection signal (TD) indicative of a detected magnitude of a target wavelength (?TG) of the radiation. Temperature sensor (34) senses a temperature of radiation detectors (31, 32) whereby temperature controller (35) regulates a heating of the radiation detectors (31, 32) relative to a regulated detector temperature (TREG).

Abstract: When an Internet Protocol (IP) telephony system receives a telephony communication setup request for a user of the IP telephony system, the IP telephony system attempts to setup the new telephony communication to the user's telephony device as an IP telephony communication that traverses a data network. However, if the called party wishes to instead setup the new telephony communication through an alternate telephony system, such as a cellular telephony system, the IP telephony system acts to facilitate the setup of the new telephony communication via that alternate telephony system. This could include placing a telephone call to the user's telephony device via the alternate telephony system, or receiving an incoming call from the user's telephony device that is received via the alternate telephony system.

Abstract: A sensor device to detect a level of carbon dioxide in a body of gas includes one or more lead selenide detectors as infrared sensing elements. The sensor device operates without temperature regulation required by conventional lead selenide-based sensors, and instead measurements of the sensor device are compensated for a temperature measured by a thermal sensor.

Abstract: Techniques for shearing a tubular of a wellbore penetrating a subterranean formation with a blowout preventer are provided. The blowout preventer has a housing with a hole therethrough for receiving the tubular. The techniques relate to a blade assembly including a ram block movable between a non-engagement position and an engagement position about the tubular, a blade carried by the ram block for cuttingly engaging the tubular, and a retractable guide carried by the ram block and slidably movable therealong. The restractable guide has a guide surface for urging the tubular into a desired location in the blowout preventer as the ram block moves to the engagement position.

Abstract: Methods and system for automating conferencing in a communication session are provided herein. In some embodiments, a method for automating conferencing in a communication session includes detecting an established communication session between a first end-user device and a second end-user device, notifying a third end-user device associated with the first user device that the established communication session is available to be joined, receiving a request from the third end-user device to join the communication session, and establishing a conference session with the first end-user device, the second-end user device, and the third end-user device.

Abstract: An IP telephony system allows a user to register a telephony device that receives its native telephony service from a different telephony service provider as an extension telephone. The user can then place calls through the IP telephony system using the extension telephone. Such calls may or may not be established using the extension telephone's native telephony service provider.

Abstract: An IP telephony system allows a user to register a telephony device that receives its native telephony service from a different telephony service provider as an extension telephone. The user can then place calls through the IP telephony system using the extension telephone. Such calls may or may not be established using the extension telephone's native telephony service provider.

Abstract: An IP telephony system allows a user to register a telephony device that receives its native telephony service from a different telephony service provider as an extension telephone. The user can then place calls through the IP telephony system using the extension telephone. Such calls may or may not be established using the extension telephone's native telephony service provider.

Abstract: A blade assembly of a blowout preventer for shearing a tubular of a wellbore penetrating a subterranean formation is provided. The blowout preventer has a housing with a hole therethrough for receiving the tubular. The blade assembly includes a ram block movable between a non-engagement position and an engagement position about the tubular, a blade carried by the ram block for cuttingly engaging the tubular, a retractable guide carried by the ram block and slidably movable therealong, and a release mechanism for selectively releasing the guide to move between a guide position for guiding engagement with the tubular and a cutting position a distance behind the blade for permitting the blade to cuttingly engage the tubular.

Abstract: A method for severing a tubular of a wellbore is provided. The method involves positioning a blowout preventer about a tubular, the blowout preventer having a plurality of rams slidably positionable therein and a plurality of blades carried by the rams for engaging the tubular. The method further involves piercing the tubular with a piercing point of at least one of the blades such that a portion of the tubular is dislodged therefrom, and raking through the tubular with a cutting surface of at least one of the blades.

Abstract: Techniques for severing a tubular of a wellbore penetrating a subterranean formation are provided. A blade is extendable by a ram of a blowout preventer positionable about the tubular. The blade includes a blade body having a front face on a side thereof facing the tubular. At least a portion of the front face has a vertical surface and at least a portion of the front face has an inclined surface. The vertical surface is perpendicular to a bottom surface of the blade body. The blade body includes a loading surface on an opposite side of the blade body to the front face. The loading surface is receivable by the ram. The blade also includes a cutting surface along at least a portion of the front face for engagement with the tubular, and a piercing point along the front face for piercing the tubular. The piercing point has a tip extending a distance from the cutting surface.