Abstract: A transvascularly placed steerable microcatheter, further including internal steerability and the ability to articulate in a direction at right angles to its longitudinal axis at or near its distal end. The steerable microcatheter is generally fabricated from stainless steel, nitinol, or other metal and includes an outer tube, an inner tube, hub structures, and a distal articulating region. The steerable microcatheter can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature. The microcatheter is especially suited to robotic or powered control applications with user intervention or using artificial intelligence (AI).

Abstract: A pharmaceutical composition for treatment of a tumor expressing at least one of a plurality of receptor proteins including CD24, Axl, DC-SIGN, Tyro3, MER, MerTK TIM-1, TIM-4, TLR3, TLR8, RIG-1, and MDA5. The pharmaceutical composition includes either a purified viral RNA of an oncolytic Zika virus in a liposome and a pharmaceutically acceptable carrier, or a pharmaceutically acceptable carrier and a unit dosage form of an oncolytic Zika virus.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: A measurement system for evaluating athletes using a weighted resistance towing sled to which an athlete is connected using a harness and tether, is described, the measurement device comprising: a force sensing device located in the connection between the athlete and the sled, the force sensing device having a load cell, the force sensing device measuring the force exerted on the sled by the athlete; a second sensing device, the second sensing device having at least one accelerometer; and a communication device for communicating data from the sensing devices, wherein the second sensing device provides data for the calculation of at least linear velocity, linear acceleration and linear distance travelled.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.

Abstract: A vessel (1) for laying a pipeline (2), comprising a tower (3) which comprises a firing line (4) and is connected to the vessel by a hinge assembly (5) comprising a tower pivot axis (6), wherein: the tower is pivotable relative to the vessel about the tower pivot axis, during pipelaying the tower comprises an upper end and a lower end and the pipeline moves relative to the vessel along the firing line in a laying direction from the upper end towards the lower end, and the tower pivot axis is located at a distance D1 from said upper end as viewed in the laying direction, a system for abandoning and recovering the pipeline, wherein: the system comprises at least one line for lowering and raising a member configured to be connected to the pipeline, and the at least one line is supported by the hinge assembly and/or by the tower at a distance of at least ? D1 from said upper end as viewed in the laying direction.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: A vessel (1) for laying a pipeline (2), comprising a tower (3) which comprises a firing line (4) and is connected to the vessel by a hinge assembly (5) comprising a tower pivot axis (6), wherein: the tower is pivotable relative to the vessel about the tower pivot axis, during pipelaying the tower comprises an upper end and a lower end and the pipeline moves relative to the vessel along the firing line in a laying direction from the upper end towards the lower end, and the tower pivot axis is located at a distance D1 from said upper end as viewed in the laying direction, a system for abandoning and recovering the pipeline, wherein: the system comprises at least one line for lowering and raising a member configured to be connected to the pipeline, and the at least one line is supported by the hinge assembly and/or by the tower at a distance of at least ? D1 from said upper end as viewed in the laying direction.

Abstract: Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.

Abstract: The present invention relates to a tubular member configured to be supported by a pipe support device on board a pipelay vessel, the tubular member comprising at least one load bearing surface which is formed along the outer side of the tubular member, the at least one load bearing surface being constructed and arranged in order to allow a substantial axial load to be imparted onto said tubular member by the pipe support device, wherein the at least one load bearing surface tapers outwardly with respect to a main longitudinal axis of said tubular member. The present invention also relates to a tubular member comprising a plurality of load bearing surfaces. The present invention also relates to a method of laying a pipeline, to a pipe support device, to a pipelay vessel, to a method of processing a tubular member, to a method of assembling a pipe assembly and to a pipe assembly.

Abstract: The invention relates to a multi-joint installation configured to join two or more pipe sections. The multi-joint installation is rotatable about an axis of rotation between a substantially horizontal and a substantially vertical position. The multi-joint installation includes two or more holding devices for holding two or more pipe sections, and at least one joining device for joining the two or more pipe sections to each other.