Patents by Inventor Eugene B. Grant

Eugene B. Grant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridine N-oxide derivatives useful as factor XIa inhibitors
    Patent number: 11814364
    Abstract: The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: November 14, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Guozhang Xu, Boying Guo, Zhijie Liu, Jing Zhang, Micheal D. Gaul, Eugene B. Grant, Mark J. Macielag, Tianbao Lu, Tho V. Thieu
  • PYRIDINE N-OXIDE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS
    Publication number: 20230091768
    Abstract: The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
    Type: Application
    Filed: March 17, 2022
    Publication date: March 23, 2023
    Inventors: Guozhang Xu, Boying Guo, Zhijie Liu, Jing Zhang, Micheal D. Gaul, Eugene B. Grant, Mark J. Macielag, Tianbao Lu, Tho V. Thieu
  • ISOINDOLIN-1-ONE DERIVATIVES USEFUL AS GRK2 INHIBITORS
    Publication number: 20220009906
    Abstract: The present invention is directed to isoindolin-1-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GRK2, including, but not limited to, cardiac failure, cardiac hypertrophy, hypertension, Type II diabetes Mellitus, NASH, NAFLD, end stage chronic kidney disease, kidney failure, etc.
    Type: Application
    Filed: June 24, 2021
    Publication date: January 13, 2022
    Inventors: Guozhang Xu, Eugene B. Grant, Gee-Hong Kuo, Micheal D. Gaul
  • 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
    Patent number: 7732612
    Abstract: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: June 8, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Eugene B. Grant, Mark J. Macielag, Steven David Paget, Michele Ann Weidner-Wells, Xiaoqing Xu, Xiaodong Xu
  • 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES
    Publication number: 20090156577
    Abstract: The present invention relates to compounds having a structure according to Formula (I) wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Application
    Filed: November 11, 2008
    Publication date: June 18, 2009
    Inventors: Benjamin Davis, Eugene B. Grant, III, Shu-Chen Lin, Mark J. Macielag, Michele Ann Weidner-Wells, Xiaoqing Xu, Xiaodong Xu, Bin Zhu
  • 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
    Patent number: 7179805
    Abstract: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: February 20, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eugene B. Grant, III, Mark J. Macielag, Xiaoqing Xu, Steven David Paget, Michele Ann Weidner-Wells
  • 6-O-carbamate-11,12-lacto-ketolide antimicrobials
    Patent number: 6713455
    Abstract: 6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: March 30, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Eugene B. Grant, III, Todd C. Henninger, Mark J. Macielag, Deodialsingh Guiadeen
  • Ketolide antibacterials
    Patent number: 6590083
    Abstract: The present invention includes compounds of the formula wherein: X is hydrogen or halide; R2 is hydrogen, acyl, or a hydroxy protecting group; R6 is hydrogen, hydroxyl, or —ORa wherein Ra is a substituted or unsubstituted moiety selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; R13 is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of methyl; C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; and, R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroc
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: July 8, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Dennis Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu, Gary Ashley
  • 6-O-carbamate-11,12-lacto-ketolide antimicrobials
    Publication number: 20030125267
    Abstract: 6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: 1
    Type: Application
    Filed: September 16, 2002
    Publication date: July 3, 2003
    Inventors: Eugene B. Grant, Todd C. Henninger, Mark J. Macielag, Deodialsingh Guiadeen
  • Ketolide antibacterials
    Patent number: 6458771
    Abstract: A series of ketolide antibacterials in the macrolide family of the formula: intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bacterial and protozoal infections and in the treatment of other conditions involving gastric motility.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: October 1, 2002
    Assignees: Ortho-McNeil Pharmaceutical, Inc., Kosan Biosciences, Inc.
    Inventors: Dennis J. Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu
  • Ketolide antibacterials
    Patent number: 6399582
    Abstract: A series of ketolide antibacterials in the macrolide family of the formula: intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bacterial and protozoal infections and in the treatment of other conditions involving gastric motility.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: June 4, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Dennis J. Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu