Patents by Inventor Eugene Chen

Eugene Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12018297
    Abstract: Provided herein is technology relating to molecular biological manipulation of genes and genomes and particularly, but not exclusively, to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) methods, compositions, systems, and kits for improved genetic editing.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: June 25, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Jie Xu, Jifeng Zhang, Yuqing Eugene Chen, Dongshan Yang
  • Publication number: 20240158567
    Abstract: Syndio-rich P3HB (sr-P3HB), readily synthesized from the eight-membered meso-dimethyl diolide, has a unique set of stereomicrostructures comprising enriched syndiotactic [rr] and no isotactic [mm] triads but abundant stereo-defects randomly distributed along the chain. This sr-P3HB material is characterized by high toughness (UT=96 MJ/m3), as a result of its high elongation at break (>400%) and tensile strength (34 MPa), crystallinity (Tm=114° C.), and optical clarity (due to its sub-micron spherulites), and good barrier properties, while it still biodegrades in freshwater and soil. On the other hand, iso-rich P3HB (ir-P3HB) can be synthesized from the eight-membered rac-dimethyl diolide. While sr-P3HB exhibits excellent adhesion strength toward a variety of substrates, both sr-P3HB and ir-P3HB can substantially toughen brittle stereoperfect biological or synthetic P3HB. Both sr-P3HB and ir-P3HB can also be obtained from the four-membered rac-beta-butyrolactone with appropriate catalysts.
    Type: Application
    Filed: October 23, 2023
    Publication date: May 16, 2024
    Inventors: Eugene CHEN, Ethan QUINN, Zhen ZHANG
  • Publication number: 20240148764
    Abstract: This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter 1 (SGLT-1) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis-related liver disease and diseases characterized with increased SGLT-1 activity, increased endoplasmic reticulum (ER) stress response, and/or increased hepatic inflammation.
    Type: Application
    Filed: March 4, 2022
    Publication date: May 9, 2024
    Inventors: Jie Xu, Kezhong Zhang, Xiubin Liang, Yuqing Eugene Chen
  • Patent number: 11824077
    Abstract: In some embodiments, a semiconductor device is provided. The semiconductor device includes an epitaxial structure having a group IV chemical element disposed in a semiconductor substrate, where the epitaxial structure extends into the semiconductor substrate from a first side of the semiconductor substrate. A photodetector is at least partially arranged in the epitaxial structure. A first capping structure having a first capping structure chemical element that is different than the first group IV chemical element covers the epitaxial structure on the first side of the semiconductor substrate. A second capping structure is arranged between the first capping structure and the epitaxial structure, where the second capping structure includes the group IV chemical element and the first capping structure chemical element.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: November 21, 2023
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Po-Chun Liu, Chung-Yi Yu, Eugene Chen
  • Publication number: 20230361148
    Abstract: In some embodiments, a method for forming a semiconductor device is provided. The method includes etching a substrate to form a recess within a surface of the substrate. An epitaxial material is formed within the recess, a capping structure is formed on the epitaxial material, and a capping layer is formed onto the capping structure. The capping layer laterally extends past an outermost sidewall of the capping structure. Dopants are implanted into the epitaxial material. Implanting the dopants into the epitaxial material forms a first doped region having a first doping type and a second doped region having a second doping type.
    Type: Application
    Filed: July 21, 2023
    Publication date: November 9, 2023
    Inventors: Po-Chun Liu, Chung-Yi Yu, Eugene Chen
  • Publication number: 20230346206
    Abstract: A surgical sheath adapted for use in the nasal cavity has an elongated hollow body made of a braided material having interstitial spaces with a dimension of 0.25 mm to 1.50 mm. The interstitial spaces filled with a filling material, such as silicone. The sheath has a low profile configuration during placement into the naris, and may be stretched into an expanded configuration. In methods of placing the sheath in the naris, the sheath is folded and then pulled into the naris using a surgical tool.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 2, 2023
    Inventors: Eugene Chen, Richard C. Ewers, Cang Lam, Stephanie Frimond
  • Publication number: 20230330259
    Abstract: The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).
    Type: Application
    Filed: May 8, 2023
    Publication date: October 19, 2023
    Inventors: Anna A. Schwendeman, Yuqing Eugene Chen, Yanhong Guo, Jifeng Zhang, Wenmin Yuan, Emily Morin
  • Publication number: 20230321179
    Abstract: The present invention relates to N-acyl amino acid products and their use in diagnosing and treating disease.
    Type: Application
    Filed: August 17, 2021
    Publication date: October 12, 2023
    Inventors: Oren Rom, Jifeng Zhang, Yuqing Eugene Chen, Ying Zhao
  • Patent number: 11737659
    Abstract: A surgical sheath adapted for use in the nasal cavity has an elongated hollow body made of a braided material having interstitial spaces with a dimension of 0.25 mm to 1.50 mm. The interstitial spaces filled with a filling material, such as silicone. The sheath has a low profile configuration during placement into the naris, and may be stretched into an expanded configuration. In methods of placing the sheath in the naris, the sheath is folded and then pulled into the naris using a surgical tool.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: August 29, 2023
    Assignee: SPIWay LLC
    Inventors: Eugene Chen, Richard C. Ewers, Cang Lam, Stephanie Frimond
  • Publication number: 20230181673
    Abstract: The present disclosure provides a method of treating NAFLD, NASH, and atherosclerosis, comprising administering glycine-containing tripeptide molecule, or a pharmaceutically acceptable salt thereof to a subject.
    Type: Application
    Filed: February 2, 2023
    Publication date: June 15, 2023
    Inventors: Oren Rom, Jifeng Zhang, Ying Zhao, Yuqing Eugene Chen
  • Patent number: 11642419
    Abstract: The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 9, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Anna A. Schwendeman, Yuqing Eugene Chen, Yanhong Guo, Jifeng Zhang, Wenmin Yuan, Emily Morin
  • Patent number: 11583313
    Abstract: In a surgical method, an access sheath is provided by a tube of a braided material. A first end of the sheath may be folded. The first end, folded or unfolded, is grasped with a distal end of a tool, which is then inserted into the nose of a patient. Advancing the tool pulls the distal end of the sheath into the nose of the patient. The sheath is then released from the tool and the tool is withdrawn. A portion of the sheath may be optionally cut off to shorten the sheath to a desired length. Typically the sheath has a total length of 70 to 180 mm and an outside diameter of 12 to 50 mm. The sheath may have a constant outside diameter along its length. The sheath may comprise silicone on the braided material.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 21, 2023
    Assignee: SPIWAY LLC
    Inventors: Eugene Chen, Richard C. Ewers, Cang Lam, Stephanie Frimond
  • Publication number: 20220322656
    Abstract: Provided herein are organ preservation solutions and methods of use thereof for preserving organs. In particular, provided herein are preservation solutions comprising a mineralocorticoid receptor antagonist, aldehyde dehydrogenase agonist, and/or histone deacetylase inhibitor, and methods of perfusing and storing an organ while awaiting transplantation or non-transplant surgery.
    Type: Application
    Filed: August 28, 2020
    Publication date: October 13, 2022
    Inventors: Zhong Wang, Paul C. Tang, Yuqing Eugene Chen, Betram Pitt, Francis D. Pagani, Ienglam Lei
  • Publication number: 20220129235
    Abstract: A method of controlling headphones having external microphone signal pass-through functionality may involve controlling a display to present a geometric shape on the display and receiving an indication of digit motion from a sensor system associated with the display. The sensor system may include a touch sensor system or a gesture sensor system. The indication may be an indication of a direction of digit motion relative to the display. The method may involve controlling the display to present a sequence of images indicating that the geometric shape either enlarges or contracts, depending on the direction of digit motion and changing a headphone transparency setting according to a current size of the geometric shape. The headphone transparency setting may correspond to an external microphone signal gain setting and/or a media signal gain setting of the headphones.
    Type: Application
    Filed: September 18, 2019
    Publication date: April 28, 2022
    Applicants: DOLBY LABORATORIES LICENSING CORPORATION, DOLBY INTERNATIONAL AB
    Inventors: Lucas E. SAULE, Eugene CHEN, Julien Guy Pierre Derreveaux, Jakub Siwak, Daniel Christian Brinkley
  • Publication number: 20220059364
    Abstract: In some embodiments, the present disclosure relates to a high-resistivity silicon-on-insulator (SOI) substrate, including a first polysilicon layer arranged over a semiconductor substrate. A second polysilicon layer is arranged over the first polysilicon layer, and a third polysilicon layer is arranged over the second polysilicon layer. An active semiconductor layer over an insulator layer may be arranged over the third polysilicon layer. The second polysilicon layer has an elevated concentration of oxygen compared to the first and third polysilicon layers.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 24, 2022
    Inventors: Yu-Hung Cheng, Cheng-Ta Wu, Chen-Hao Chiang, Alexander Kalnitsky, Yeur-Luen Tu, Eugene Chen
  • Patent number: 11227226
    Abstract: Methods, systems, and computer readable storage media are disclosed for generating joint-probabilistic ensemble forecasts for future events based on a plurality of different prediction models for the future events. For example, in one or more embodiments the disclosed system determines error values for various predictions from a plurality of different prediction models (i.e., “forecasters”) for previous events. Moreover, in one or more embodiments the system generates an error probability density function by mapping the error values to an error space and applying a kernel density estimation. Furthermore, the system can apply the error probability density function(s) to a plurality of predictions from the forecasters for a future event to generate a likelihood function and a new prediction for the future event.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: January 18, 2022
    Assignee: ADOBE INC.
    Inventors: Eugene Chen, Zhenyu Yan, Xiaojing Dong
  • Patent number: 11171015
    Abstract: In some embodiments, the present disclosure relates to a high-resistivity silicon-on-insulator (SOI) substrate, including a first polysilicon layer arranged over a semiconductor substrate. A second polysilicon layer is arranged over the first polysilicon layer, and a third polysilicon layer is arranged over the second polysilicon layer. An active semiconductor layer over an insulator layer may be arranged over the third polysilicon layer. The second polysilicon layer has an elevated concentration of oxygen compared to the first and third polysilicon layers.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: November 9, 2021
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yu-Hung Cheng, Cheng-Ta Wu, Chen-Hao Chiang, Alexander Kalnitsky, Yeur-Luen Tu, Eugene Chen
  • Patent number: 11164844
    Abstract: In some embodiments, the present disclosure relates to a method of forming a package assembly. A wet etch stop layer is formed over a frontside of a semiconductor substrate. A sacrificial semiconductor layer is formed over the wet etch stop layer, and a dry etch stop layer is formed over the sacrificial semiconductor layer. A stack of semiconductor device layers may be formed over the dry etch stop layer. A bonding process is performed to bond the stack of semiconductor device layers to a frontside of an integrated circuit die, wherein the frontside of the semiconductor substrate faces the frontside of the integrated circuit die. A wet etching process is performed to remove the semiconductor substrate, and a dry etching process is performed to remove the wet etch stop layer and the sacrificial semiconductor layer.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: November 2, 2021
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Chen Yu Chen, Ming Chyi Liu, Eugene Chen
  • Patent number: D999374
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: September 19, 2023
    Assignee: SPIWAY LLC
    Inventors: Eugene Chen, Richard C. Ewers, Cang Lam, Stephanie Frimond
  • Patent number: D999375
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: September 19, 2023
    Assignee: SPIWAY LLC
    Inventors: Eugene Chen, Richard C. Ewers, Cang Lam, Stephanie Frimond