Abstract: The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

Abstract: Embodiments of the invention provide a stretchable sleeve having a medicinal section that can be loaded with a medicinal composition and a perforated section comprising a plurality of openings, wherein the medicinal section and the perforated section overlap, and wherein the sleeve is sized so that the interior surface of the medicinal section comfortably fits a body portion and the medicinal section contacts the body portion at the site of pain. Embodiments of the invention also provide methods for preparing a sleeve by applying a medicinal composition to the inner surface of the medicinal section through the openings at the perforated section. Embodiments of the invention also provide methods for relieving pain in a body portion by pulling the sleeve in an outside-out configuration straight up a body portion without having to roll and flip its exterior surface outside.

Abstract: Embodiments of the invention provide a stretchable sleeve having a medicinal section that can be loaded with a medicinal composition and a perforated section comprising a plurality of openings, wherein the medicinal section and the perforated section overlap, and wherein the sleeve is sized so that the interior surface of the medicinal section comfortably fits a body portion and the medicinal section contacts the body portion at the site of pain. Embodiments of the invention also provide methods for preparing a sleeve by applying a medicinal composition to the inner surface of the medicinal section through the openings at the perforated section. Embodiments of the invention also provide methods for relieving pain in a body portion by pulling the sleeve in an outside-out configuration straight up a body portion without having to roll and flip its exterior surface outside.