Patents by Inventor Eugene E. Varfolomeev

Eugene E. Varfolomeev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of regulatory proteins
    Patent number: 7101675
    Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: September 5, 2006
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark P Boldin, Eugene E Varfolomeev, Zeev Pancer, Igor Mett, Tanya M Goncharov
  • Modulators of regulatory proteins
    Publication number: 20020123117
    Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.
    Type: Application
    Filed: January 4, 2002
    Publication date: September 5, 2002
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark P. Boldin, Eugene E. Varfolomeev, Zeev Pancer, Igor Mett, Tanya M. Goncharov
  • Antibodies to the death domain motifs of regulatory proteins
    Patent number: 6355780
    Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a “death domain” motif is provided. The “death domain” is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more “death domain” motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interating with “death domain” motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankryin, as illustrated in the Figure. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the “death domain”.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: March 12, 2002
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark P. Boldin, Eugene E. Varfolomeev, Zeev Pancer, Igor Mett, Tanya M. Goncharov