Abstract: A simple and potentially disposable compact probe of FIG. 1, which is primarily aimed to be used for radio-guided or fluorescence-guided surgery, diagnostics or biopsy, and method of using it, is invented. The novel method reduces limitations inherent to the existing technologies. It consists in shifting most of the functions (signal analysis, detector controls and user visual and audio interfaces) from the probe to an external personal computer connected with the probe via wireless link. Maximum simplification and miniaturization of the probe itself makes it potentially disposable, supplied in sterile package similar to disposable syringe. Due to use of single photon time-resolved counting photo-sensors and microelectronic circuits with sub-nanosecond timing, the probe can be used with fluorescent markers as well. New probe should enhance efficiency of medical procedures and open opportunities for more wide application of the intra-operative probing techniques in medical practice, especially in oncology.

Abstract: A monolithic active pixel dosimeter, provided with at least a sensing cell, having at least a junction sensing element. The junction sensing element includes a sensing region, having a first type of conductivity, and a charge collecting region, contiguous to the sensing region and having a second type of conductivity. The sensing cell further includes an ohmic region at least partially overlapping and extending laterally outside the charge collecting region, and an annular insulating region, abutting the ohmic region, so as to form an insulating junction surrounding both the ohmic region and the charge collection region.

Abstract: A monolithic active pixel dosimeter, provided with at least a sensing cell, having at least a junction sensing element. The junction sensing element includes a sensing region, having a first type of conductivity, and a charge collecting region, contiguous to the sensing region and having a second type of conductivity. The sensing cell further includes an ohmic region at least partially overlapping and extending laterally outside the charge collecting region, and an annular insulating region, abutting the ohmic region, so as to form an insulating junction surrounding both the ohmic region and the charge collection region.