Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salts thereof; wherein the variables R1—R5, Ar1, and X are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: This invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The compounds of Formula I are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: This invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The compounds of Formula I are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: This invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, n, X1, X2, L1, and L2 are as defined herein. The compounds of Formula I are useful as receptor tyrosine kinase (RTK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases.

Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salts thereof; wherein the variables R1-R5, Ar1, and X are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The invention is a method and kit for conducting a rapid toxicity test. Methods and kits according to the invention include an animal or plant species in diapause.

Abstract: A table cover assembly for covering a table-top is provided. The table cover assembly comprises a flexible table cover, one or more cords, and locking elements. The flexible table cover is configured to be securely and immovably positioned on table-tops having a shape generally similar to the shape of the flexible table cover. The flexible table cover comprises one or more layers affixed to one another to create the flexible table cover. The flexibly table cover is hemmed around its periphery. The hemmed periphery defines an interstitial cavity extending along the hemmed periphery for inserting a cord which can be tightened and locked using the locking elements, for positioning the flexible table cover on the table-top to provide a secure, immovable and smooth surface on the table-top. The flexible table cover allows guidable and bounceable movement of articles placed on the flexible table cover covering the table-top.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: A tool having a telescoping handle including a main shank and an outer sleeve complementary shaped to receive the main shank therein. A guide groove is formed in an outer circumferential surface of the main shank for receiving a guide pin formed or attached to an inner circumferential surface of the outer sleeve. A locking collar may be provided to cause a bearing member to selectively engage locking structures formed on the main shank in order to selectively lock the telescoping handle in selected positions. The bearing member may also serve as the guide pin. Alternatively, at least two distinct locking and release mechanisms may be provided to selectively lock the telescoping handle in selected positions.

Abstract: Active and spare battery holders are removably disposed within a battery compartment of a battery operated device such that battery cells in the active holder provide electrical power to operate the device, while battery cells in the spare holder are electrically isolated to prevent their discharge. In one embodiment, upon discharge of the battery cells of the active holder the cells of the active holder and the spare holder are exchanged, providing the active holder with fresh cells to operate the device. In another embodiment, the active and spare holders are simply interchanged, so that the spare holder becomes the active holder and the active holder becomes the spare holder. According to the latter embodiment, a unitary battery holder includes a first and second battery holder in a single unit, so that to interchange active and spare holders the unitary battery holder is reversed within the battery compartment.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract: A mobile recharging power source with a lighting accessory includes a battery pack, the battery pack having a plurality of battery cells contained within a housing and electrically connected to a receiving connector disposed on the housing. A lamp may be provided on the housing, along with a switch to turn the lamp on and off. A lighting accessory is provided for connection to the receiving connector of the battery pack. The lighting accessory includes at least one light source, such as an incandescent or LED lamp, and the light source is connected to a mating connector which is adapted for connection to the receiving connector of the battery pack. Additionally, a charging accessory is provided having a mating connector for connection to the receiving connector, and a device specific connector adapted for connection to a recharging port of a portable electronic device.