Patents by Inventor Eugene J. Trybulski
Eugene J. Trybulski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110212923Abstract: The present invention relates to phosphate derivatives of estrogen receptor beta agonists, compositions thereof, preparations thereof, and uses thereof. Formula (I).Type: ApplicationFiled: February 6, 2009Publication date: September 1, 2011Inventors: Reinhardt Baudy, Eugene J. Trybulski, Ronald Magolda, Diane Schneider, Gulnaz Khafizova, Mahdi B. Fawzi, Cuijian Yang
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Patent number: 7678787Abstract: This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).Type: GrantFiled: June 8, 2006Date of Patent: March 16, 2010Assignee: WyethInventors: Amedeo A. Failli, Gavin D. Heffernan, Arthur A. Santilli, Dominick A. Quagliato, Richard D. Coghlan, Patrick M. Andrae, Susan C. Croce, Emily S. Shen, Eugene J. Trybulski
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Patent number: 7662831Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.Type: GrantFiled: July 26, 2007Date of Patent: February 16, 2010Assignee: Wyeth LLCInventors: Matthew A. Wilson, Gregory S. Welmaker, Eugene J. Trybulski, John A. Butera, Ronald L. Magolda
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Patent number: 7601856Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.Type: GrantFiled: July 26, 2007Date of Patent: October 13, 2009Assignee: WyethInventors: Gregory S. Welmaker, Matthew A. Wilson, Geraldine McFarlane, Joan E. Sabalski, John A. Butera, Eugene J. Trybulski, David R. Herbst
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Publication number: 20090227565Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturatType: ApplicationFiled: November 10, 2008Publication date: September 10, 2009Applicant: WYETHInventors: Amedeo A. FAILLI, John P. DUSZA, Thomas J. CAGGIANO, Jay S. SHUMSKY, Kevin A. MEMOLI, Eugene J. TRYBULSKI
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Patent number: 7585871Abstract: The present invention relates generally to phenanthridine carbonyl compositions such as substituted phenanthridine carbonyl phenols of Formula 1: wherein R1 to R15 are as defined in the specification, or pharmaceutically acceptable salts thereof; and methods of using them.Type: GrantFiled: August 30, 2005Date of Patent: September 8, 2009Assignee: WyethInventors: Robert John Steffan, William Jay Moore, Eugene J. Trybulski, Albert John Molinari
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Patent number: 7465722Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturatedType: GrantFiled: August 11, 2006Date of Patent: December 16, 2008Assignee: WyethInventors: Amedeo A. Failli, John P. Dusza, Thomas J. Caggiano, Jay S. Shumsky, Kevin A. Memoli, Eugene J. Trybulski
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Publication number: 20080027090Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.Type: ApplicationFiled: July 26, 2007Publication date: January 31, 2008Applicant: WYETHInventors: Matthew A. WILSON, Gregory S. WELMAKER, Eugene J. Trybulski, John A. BUTERA, Ronald L. MAGOLDA
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Publication number: 20080027049Abstract: The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.Type: ApplicationFiled: July 26, 2007Publication date: January 31, 2008Applicant: WYETHInventors: Gregory S. WELMAKER, Matthew A. WILSON, Geraldine R. McFARLANE, Joan E. SABALSKI, John A. BUTERA, Eugene J. Trybulski, David R. HERBST
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Patent number: 7223752Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1–C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, halogen or (C1–C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, or (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturatType: GrantFiled: November 4, 2004Date of Patent: May 29, 2007Assignee: WyethInventors: Amedeo Arturo Failli, John P. Dusza, Thomas Joseph Caggiano, Jay Scott Shumsky, Kevin A. Memoli, Eugene J. Trybulski
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Patent number: 7138393Abstract: Novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical formulations containing such compounds which are useful as anti-aquaretic agents in the treatment of nocturnal urinary enuresis, nocturnal urinary urgency, and/or similar conditions.Type: GrantFiled: December 16, 2002Date of Patent: November 21, 2006Assignee: WyethInventors: Albert J. Molinari, Eugene J. Trybulski
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Patent number: 6903091Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heteType: GrantFiled: April 11, 2002Date of Patent: June 7, 2005Assignee: WyethInventors: Amedeo A. Failli, Thomas J. Caggiano, Jay S. Shumsky, Eugene J. Trybulski, Kevin A. Memoli, John P. Dusza
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Publication number: 20030134845Abstract: Novel compounds of Formula (I) 1Type: ApplicationFiled: December 16, 2002Publication date: July 17, 2003Applicant: WyethInventors: Albert J. Molinari, Eugene J. Trybulski
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Patent number: 6511974Abstract: This invention relates to new compounds selected from those of the general formula (I), or a pharmaceutically acceptable salt, ester or prodrug form thereof: wherein D, E and G are N or CH, which serve as vasopressin agonists and are useful in treating disorders such as diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, and the inability to temporarily delay urination and pharmaceutical compositions and methods for same.Type: GrantFiled: July 24, 1998Date of Patent: January 28, 2003Assignee: WyethInventors: John P. Dusza, Peter S. Chan, Jay D. Albright, Jehan F. Bagli, Amedeo A. Failli, Mark A. Ashwell, Albert J. Molinari, Thomas J. Caggiano, Eugene J. Trybulski
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Publication number: 20030018024Abstract: A compound of the formulae (I) or (II): 1Type: ApplicationFiled: April 11, 2002Publication date: January 23, 2003Applicant: WyethInventors: Amedeo Arturo Failli, Thomas Joseph Caggiano, Jay Scott Shumsky, Eugene J. Trybulski, Kevin A. Memoli, John P. Dusza
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Patent number: 6235900Abstract: The present invention provides compounds of the general formula: as well as methods and pharmaceutical compositions utilizing these compounds for the inducement of temporary delay of urination or the treatment of disorders which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders.Type: GrantFiled: February 1, 2000Date of Patent: May 22, 2001Assignee: American Home Products CorporationInventors: Amedeo A. Failli, Jay S. Shumsky, Eugene J. Trybulski
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Patent number: 5932745Abstract: This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined below: ##STR1##Type: GrantFiled: June 30, 1998Date of Patent: August 3, 1999Assignee: American Home Products CorporationInventors: Russell G. Dushin, Eugene J. Trybulski
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Patent number: 5880122Abstract: This invention relates to tricyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction, the compounds having the general structure: ##STR1##Type: GrantFiled: October 22, 1997Date of Patent: March 9, 1999Assignee: American Home Products CorporationInventors: Eugene J. Trybulski, Albert J. Molinari, Jehan F. Bagli, Mark A. Ashwell, Thomas J. Caggiano
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Patent number: 5637731Abstract: This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds.Type: GrantFiled: April 30, 1996Date of Patent: June 10, 1997Assignee: American Home Products CorporationInventors: Eugene J. Trybulski, Richard H. Kramss, Herbert J. Brabander
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Patent number: 5550257Abstract: This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds.Type: GrantFiled: February 22, 1995Date of Patent: August 27, 1996Assignee: American Cyanamid CompanyInventors: Eugene J. Trybulski, Richard H. Kramss, Herbert J. Brabander