Patents by Inventor Eugene L. Stewart

Eugene L. Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20230287028
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Application
    Filed: April 28, 2023
    Publication date: September 14, 2023
    Inventors: Michael Joseph BISHOP, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • C-mannoside compounds useful for the treatment of urinary tract infections
    Patent number: 11697665
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: July 11, 2023
    Assignees: Fimbrion Therapeutics, Inc., GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Michael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20210395287
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Application
    Filed: July 9, 2021
    Publication date: December 23, 2021
    Inventors: Michael Joseph BISHOP, Eugene L. STEWART, Katherine Louisa WIDDOWSON, James Walter JANETKA, Laurel Kathryn MCGRANE
  • C-mannoside compounds useful for the treatment of urinary tract infections
    Patent number: 11111262
    Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: September 7, 2021
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Fimbrion Therapeutics, Inc.
    Inventors: Michael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • 1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin D synthase inhibitors
    Patent number: 11053234
    Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: July 6, 2021
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: David Norman Deaton, Yu Guo, Ashley Paul Hancock, Christie Schulte, Barry George Shearer, Emilie Despagnet Smith, Eugene L. Stewart, Stephen Andrew Thomson
  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20210017212
    Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
    Type: Application
    Filed: October 6, 2020
    Publication date: January 21, 2021
    Inventors: Michael Joseph BISHOP, Vincent J. Colandrea, Yuehu Li, Eugene L. Stewart, Iulia Strambeanu, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn Mcgrane
  • COMBINATIONS AND USES AND TREATMENTS THEREOF
    Publication number: 20200246351
    Abstract: Methods for treating or preventing HIV in a patient using a combination of bictegravir and lamivudine and optionally with other anti-HIV agents are disclosed, as well as compositions containing such compounds.
    Type: Application
    Filed: August 2, 2018
    Publication date: August 6, 2020
    Inventors: Mark I. COCKETT, Eugene L. STEWART, Mark Richard UNDERWOOD, Cindy L. VAVRO
  • COMBINATIONS AND USES AND TREATMENTS
    Publication number: 20200171039
    Abstract: Methods for treating or preventing HIV in a patient using a combination of bictegravir and emtricitabine and optionally with other anti-HIV agents are disclosed, as well as compositions containing such compounds.
    Type: Application
    Filed: August 2, 2018
    Publication date: June 4, 2020
    Inventors: Mark I. COCKETT, Eugene L. STEWART, Mark Richard UNDERWOOD, Cindy L. VAVRO
  • 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS
    Publication number: 20190241554
    Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 8, 2019
    Inventors: David Norman DEATON, Yu GUO, Ashley Paul HANCOCK, Christie SCHULTE, Barry George SHEARER, Emilie Despagnet SMITH, Eugene L. STEWART, Stephen Andrew THOMSON
  • Positive allosteric modulators of human melanocortin-4 receptor
    Patent number: 10294214
    Abstract: Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: May 21, 2019
    Assignees: Vanderbilt University, King's College London, Glaxo Group Limited
    Inventors: Roger D. Cone, Michael J. Bishop, Eugene L. Stewart, Lawrence A. Wolfe, Jaques Pantel, Julien Sebag, C. David Weaver, Savannah Williams, Helen Cox, Iain Tough, Luis Diaz Gimenez, Subramanian Baskaran
  • POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR
    Publication number: 20170349571
    Abstract: Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 7, 2017
    Inventors: Roger D. Cone, Michael J. Bishop, Eugene L. Stewart, Lawrence A. Wolfe, Jaques Pantel, Julien Sebag, C. David Weaver, Savannah Williams, Helen Cox, Ian Tough, Luis Diaz Gimenez, Subramanian Baskaran
  • Chemical compounds
    Patent number: 8673948
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: March 18, 2014
    Assignee: GlaxoSmithKline, LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • CHEMICAL COMPOUNDS
    Publication number: 20110301203
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: August 19, 2011
    Publication date: December 8, 2011
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Chemical compounds
    Patent number: 8026262
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: September 27, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • CHEMICAL COMPOUNDS
    Publication number: 20090264482
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 22, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Chemical compounds
    Patent number: 7572820
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • CHEMICAL COMPOUNDS
    Publication number: 20080139631
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: September 27, 2007
    Publication date: June 12, 2008
    Applicant: SmithKline Beecham Corporation
    Inventors: Philip Stewart TURNBULL, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Substitued aminopropoxyaryl derivatives useful as agonists for lxr
    Publication number: 20040072868
    Abstract: 1
    Type: Application
    Filed: March 18, 2003
    Publication date: April 15, 2004
    Inventors: Jon Loren Collins, Adam M. Fivush, Patrick Reed Maloney, Eugene L. Stewart, Timothy Mark Willson