Patents by Inventor Eugene Lukhtanov

Eugene Lukhtanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYPERTHERMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE
    Publication number: 20130022976
    Abstract: The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 24, 2013
    Inventors: Yevgeniy Belousov, Eugene Lukhtanov
  • Amide-substituted xanthene dyes
    Patent number: 8163910
    Abstract: The present invention provides amide-substituted xanthene fluorescent dyes and reagent for the introduction of phosphonate or sulfo groups into the fluorescent dyes.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: April 24, 2012
    Assignee: Elitech Holding B.V.
    Inventor: Eugene Lukhtanov
  • Real-time linear detection probes: sensitive 5?-minor groove binder-containing probes for amplification (or PCR) analysis
    Patent number: 7759126
    Abstract: Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: July 20, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Sergey Lokhov, Eugene Lukhtanov
  • MINOR GROOVE BINDER - ENERGY TRANSFER OLIGONUCLEOTIDES AND METHODS FOR THEIR USE
    Publication number: 20090111100
    Abstract: The incorporation of a minor groove binder spaced close to one member of a matched FRET set in a minor groove binder-oligonucleotide conjugate significantly reduces background fluorescence of a FRET probe or pair of probes and, consequently, increases the S/B ratios. Fluorescent-labeled probes are useful in carrying out hybridization, multiplex nucleic acid detection, and other procedures.
    Type: Application
    Filed: October 30, 2007
    Publication date: April 30, 2009
    Inventors: Eugene Lukhtanov, Noah Scarr
  • AMIDE-SUBSTITUTED XANTHENE DYES
    Publication number: 20090093612
    Abstract: The present invention provides amide-substituted xanthene fluorescent dyes and reagent for the introduction of phosphonate or sulfo groups into the fluorescent dyes.
    Type: Application
    Filed: October 2, 2008
    Publication date: April 9, 2009
    Applicant: Epoch Biosciences, Inc.
    Inventor: Eugene Lukhtanov
  • FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND
    Publication number: 20080293586
    Abstract: Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal.
    Type: Application
    Filed: March 12, 2008
    Publication date: November 27, 2008
    Applicant: Epoch Biosciences, Inc.
    Inventors: Sergey Lokhov, Eugene Lukhtanov
  • Fluorescent probes containing 5?-minor groove binder, fluorophore and quenching moieties and methods of use thereof
    Patent number: 7381818
    Abstract: Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: June 3, 2008
    Assignee: Epoch Biosciences, Inc.
    Inventors: Sergey Lokhov, Eugene Lukhtanov
  • IMPROVED PRIMER-BASED AMPLIFICATION METHODS
    Publication number: 20070048758
    Abstract: The present invention provides methods for amplifying a target nucleic acid with greater efficiency and accuracy by using one or more flap primers.
    Type: Application
    Filed: June 9, 2006
    Publication date: March 1, 2007
    Applicant: Epoch Biosciences, Inc.
    Inventors: Sergey Lokhov, Alan Mills, Eugene Lukhtanov
  • Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background
    Publication number: 20050214797
    Abstract: Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background signal.
    Type: Application
    Filed: October 27, 2004
    Publication date: September 29, 2005
    Applicant: EPOCH BIOSCIENCES, INC
    Inventors: Sergey Lokhov, Eugene Lukhtanov