Abstract: A Microfluidic Modulation Spectroscopy (e.g. MMS) system enables measurement of a liquid analyte with a weak absorbance in a prescribed reference solution with a very high absorbance. The method includes alternatively flowing the liquid analyte and the prescribed reference solution through a fluid chamber in a liquid flow cell. The temperature of the analyte can be changed following a predetermined curve while spectral data is being collected. As the temperature of the analyte is increased, outgassing of trapped and dissolved air dissolved in the liquid analyte may be reduced, especially within the interrogation region of the flow cell, by application of a backpressure to the exit line of the flow cell. This is important for proteins, RNA, DNA, and other biomolecules because their structure and function are often temperature dependent. Further, some biological drugs need to be distributed globally and may encounter a range of ambient conditions in shipping.

Abstract: A flow meter is positioned in an Microfluidic Modulation Spectroscopy system at the output of the Y junction of a flow cell. The MMS system instantaneously measures the flow rate through the flow cell and adjusts parameters such as fluid backing pressure, valve open time, and dwell time before data collection. This allows an opportunity to optimize the system performance and minimize the fluid usage in real time. The flow sensor is capable of measuring fluid flow in the range of 0-100 microliter per second. The incorporation of the flow meter at the output of the Y junction immediately following measurement of the sample and reference fluids allows for real-time adjustments of operating parameters. The capability of the system to adjust operating parameters and make corrections in real time based on the measurements by the flow meter allows the instrument to automatically measure arrays of samples on a well plate.

Abstract: Systems and methods are described for load balancing between a set of servers. Subsets of servers from the set of servers are assigned, via deterministic subsetting, to respective clients from a set of clients. Unlike conventional load balancing techniques using deterministic subsetting, the disclosed techniques enable configuring a client to distribute different amounts of load among the servers in its server subset. Techniques for constructing the subsets are also described.

Abstract: Systems and methods are described for load balancing between a set of servers. Subsets of servers from the set of servers are assigned, via deterministic subsetting, to respective clients from a set of clients. Unlike conventional load balancing techniques using deterministic subsetting, the disclosed techniques enable configuring a client to distribute different amounts of load among the servers in its server subset. Techniques for constructing the subsets are also described.

Abstract: Systems and methods are described for load balancing between a set of servers. Subsets of servers from the set of servers are assigned, via deterministic subsetting, to respective clients from a set of clients. Unlike conventional load balancing techniques using deterministic subsetting, the disclosed techniques enable configuring a client to distribute different amounts of load among the servers in its server subset. Techniques for constructing the subsets are also described.

Abstract: Systems and methods are described for load balancing between a set of servers. Subsets of servers from the set of servers are assigned, via deterministic subsetting, to respective clients from a set of clients. Unlike conventional load balancing techniques using deterministic subsetting, the disclosed techniques enable configuring a client to distribute different amounts of load among the servers in its server subset. Techniques for constructing the subsets are also described.

Abstract: Systems and methods are described for load balancing between a set of servers. Subsets of servers from the set of servers are assigned, via deterministic subsetting, to respective clients from a set of clients. Unlike conventional load balancing techniques using deterministic subsetting, the disclosed techniques enable configuring a client to distribute different amounts of load among the servers in its server subset. Techniques for constructing the subsets are also described.

Abstract: According to various embodiments and aspects of the present invention, there is provided a dynamically tunable thin film interference coating including one or more layers with thermo-optically tunable refractive index. Tunable layers within thin film interference coatings enable a new family of thin film active devices for the filtering, control, modulation of light. Active thin film structures can be used directly or integrated into a variety of photonic subsystems to make tunable lasers, tunable add-drop filters for fiber optic telecommunications, tunable polarizers, tunable dispersion compensation filters, and many other devices.

Abstract: An optical device including: a glass substrate; a crystalline silicon layer bonded to the glass substrate; and a thermally tunable thin-film optical filter fabricated on top of the crystalline silicon layer.

Abstract: An optical device including: a substrate with a top surface and a bottom surface and a hole extending through the substrate from the top surface to the bottom surface; and a multilayered thin film structure fabricated on the substrate and forming a membrane over the hole, the multilayered thin film structure including a thermally tunable thin film optical filter structure at least a portion of which is positioned over the hole.

Abstract: An optical sensor for detecting a chemical in a sample region includes an emitter for producing light, and for directing the light through the sample region. The sensor also includes a detector for receiving the light after the light passes through the sample region, and for producing a signal corresponding to the light the detector receives. The sensor further includes a thermo-optic filter disposed between the emitter and the detector. The optical filter has a tunable passband for selectively filtering the light from the emitter. The passband of the optical filter is tunable by varying a temperature of the optical filter. The sensor also includes a controller for controlling the passband of the optical filter and for receiving the detection signal from the detector. The controller modulates the passband of the optical filter and analyzes the detection signal to determine whether an absorption peak of the chemical is present.

Abstract: According to various embodiments and aspects of the present invention, there is provided a dynamically tunable thin film interference coating including one or more layers with thermo-optically tunable refractive index. Tunable layers within thin film interference coatings enable a new family of thin film active devices for the filtering, control, modulation of light. Active thin film structures can be used directly or integrated into a variety of photonic subsystems to make tunable lasers, tunable add-drop filters for fiber optic telecommunications, tunable polarizers, tunable dispersion compensation filters, and many other devices.

Abstract: According to various embodiments and aspects of the present invention, there is provided a dynamically tunable thin film interference coating including one or more layers with thermo-optically tunable refractive index. Tunable layers within thin film interference coatings enable a new family of thin film active devices for the filtering, control, modulation of light. Active thin film structures can be used directly or integrated into a variety of photonic subsystems to make tunable lasers, tunable add-drop filters for fiber optic telecommunications, tunable polarizers, tunable dispersion compensation filters, and many other devices.