Patents by Inventor Eugene Major

Eugene Major has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting JC virus (JCV)
    Patent number: 10036020
    Abstract: The instant invention provides compositions and methods for inhibiting the JC Virus (JCV), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (PML). Antisense oligonucleotides are provided which are effective in inhibiting JCV replication or multiplication, alone or in a combination. In preferred embodiments, the oligonucleotides contain modifications.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: July 31, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Laura B. Jaeger, Avindra Nath, Eugene Major, Maria Chiara Kushner-Monaco, Michael W. Ferenczy
  • Methods and compositions for identifying JC virus
    Patent number: 9631243
    Abstract: The disclosure relates to methods and compositions for detecting the presence of Prototype and/or Archetype JC virus in a biological sample from a subject. In some embodiments, the methods include amplifying and detecting a first nucleic acid sequence unique to Archetype JC virus in a biological sample, and a second nucleic acid sequence common to both Archetype and Prototype JC virus in the biological sample. In several embodiments, the methods can be used to identify JC virus in a biological sample from a subject at risk for progressive multifocal leukoencephalopathy. Compositions and kits for use in the disclosed methods are also provided.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: April 25, 2017
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Eugene Major, Caroline Ryschkewitsch
  • COMPOSITIONS AND METHODS FOR INHIBITING JC VIRUS (JCV)
    Publication number: 20160272974
    Abstract: The instant invention provides compositions and methods for inhibiting the JC Virus (JCV), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (PML). Antisense oligonucleotides are provided which are effective in inhibiting JCV replication or multiplication, alone or in a combination. In preferred embodiments, the oligonucleotides contain modifications.
    Type: Application
    Filed: September 19, 2014
    Publication date: September 22, 2016
    Applicant: The U.S.A. as represented by the Secretary, Dept. of Health & Human Services
    Inventors: Laura B. Jaeger, Avindra Nath, Eugene Major, Maria Chiara Kuschner-Monaco, Michael W. Ferenczy
  • METHODS AND COMPOSITIONS FOR IDENTIFYING JC VIRUS
    Publication number: 20150176089
    Abstract: The disclosure relates to methods and compositions for detecting the presence of Prototype and/or Archetype JC virus in a biological sample from a subject. In some embodiments, the methods include amplifying and detecting a first nucleic acid sequence unique to Archetype JC virus in a biological sample, and a second nucleic acid sequence common to both Archetype and Prototype JC virus in the biological sample. In several embodiments, the methods can be used to identify JC virus in a biological sample from a subject at risk for progressive multifocal leukoencephalopathy. Compositions and kits for use in the disclosed methods are also provided.
    Type: Application
    Filed: June 17, 2013
    Publication date: June 25, 2015
    Inventors: Eugene Major, Caroline Ryschkewitsch