Patents by Inventor Eugene Maraskovsky

Eugene Maraskovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of FVIII immunogenicity by truncated VWF
    Patent number: 11141466
    Abstract: The present invention relates to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) capable of binding to blood coagulation Factor VIII (FVIII) for use in reducing the immunogenicity of Factor VIII (FVIII) wherein said recombinant polypeptide and a blood coagulation Factor VIII (FVIII) protein are co-administered to a subject suffering from a 10 blood coagulation disorder. The invention further relates to pharmaceutical compositions and kits for said use.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 12, 2021
    Assignee: CSL Behring Lengnau AG
    Inventors: Anne Verhagen, Sabine Pestel, Thomas Weimer, Marco Hofmann, Huy Huynh, Eugene Maraskovsky
  • METHOD OF TREATING CANCER
    Publication number: 20210292411
    Abstract: The present disclosure provides a method for enhancing or inducing an immune response and/or for inducing lysis of cancer cells and/or for treating cancer in a subject, the method comprising administering to the subject a compound that neutralizes BTN2A1 and/or that binds to BTN2A1 on the cells and induces death of the cells.
    Type: Application
    Filed: November 4, 2020
    Publication date: September 23, 2021
    Inventors: Andreas BEHREN, Jonathan CEBON, Christopher HUDSON, Katherine WOODS, Andrew HAMMET, Anne VERHAGEN, Eugene MARASKOVSKY, Con PANOUSIS
  • ANTI-TUMOR COMPOSITIONS AND USES THEREOF
    Publication number: 20210252136
    Abstract: The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.
    Type: Application
    Filed: October 16, 2020
    Publication date: August 19, 2021
    Inventors: Adriana BAZMORELLI, Eugene MARASKOVSKY
  • MODULATION OF FVIII IMMUNOGENICITY BY TRUNCATED VWF
    Publication number: 20200197495
    Abstract: The present invention relates to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) capable of binding to blood coagulation Factor VIII (FVIII) for use in reducing the immunogenicity of Factor VIII (FVIII) wherein said recombinant polypeptide and a blood coagulation Factor VIII (FVIII) protein are co-administered to a subject suffering from a 10 blood coagulation disorder. The invention further relates to pharmaceutical compositions and kits for said use.
    Type: Application
    Filed: June 22, 2018
    Publication date: June 25, 2020
    Inventors: Anne VERHAGEN, Sabine PESTEL, Thomas WEIMER, Marco HOFMANN, Huy HUYNH, Eugene MARASKOVSKY
  • Financial Method
    Publication number: 20200030440
    Abstract: The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.
    Type: Application
    Filed: October 3, 2018
    Publication date: January 30, 2020
    Inventors: Adriana BAZMORELLI, Eugene MARASKOVSKY
  • METHOD OF TREATING CANCER
    Publication number: 20190023783
    Abstract: The present disclosure provides computer-implemented methods of organising the marketing of a compound that neutralises BTN2A1.
    Type: Application
    Filed: July 31, 2018
    Publication date: January 24, 2019
    Inventors: Andreas BEHREN, Jonathan CEBON, Christopher HUDSON, Katherine WOODS, Andrew HAMMET, Anne VERHAGEN, Eugene MARASKOVSKY, Con PANOUSIS
  • Compositions and methods for targeting type 1 interferon producing cells
    Patent number: 9758585
    Abstract: The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor ? (IL-3R?) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: September 12, 2017
    Assignee: CSL Limited
    Inventors: Gino Luigi Vairo, Andrew Nash, Eugene Maraskovsky, Nick Wilson, Samantha Busfield, Con Panousis
  • ANTI-TUMOR COMPOSITIONS AND USES THEREOF
    Publication number: 20170014507
    Abstract: The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.
    Type: Application
    Filed: September 30, 2016
    Publication date: January 19, 2017
    Inventors: Adriana Bazmorelli, Eugene Maraskovsky
  • METHOD OF TREATING CANCER
    Publication number: 20160376364
    Abstract: The present disclosure provides a method for enhancing or inducing an immune response and/or for inducing lysis of cancer cells and/or for treating cancer in a subject, the method comprising administering to the subject a compound that neutralizes BTN2A1 and/or that binds to BTN2A1 on the cells and induces death of the cells.
    Type: Application
    Filed: November 28, 2014
    Publication date: December 29, 2016
    Inventors: Andreas BEHREN, Jonathan CEBON, Christopher HUDSON, Katherine WOODS, Andrew HAMMET, Anne VERHAGEN, Eugene MARASKOVSKY, Con PANOUSIS
  • Treatment of neurological conditions
    Patent number: 9364534
    Abstract: The present invention is directed to a method for treating an inflammatory neurodegenerative condition of the CNS in a subject comprising administering to said subject a G-CSF or G-CSFR inhibiting agent selected from the group consisting of an antibody specific for G-CSF or G-CSFR, a soluble G-CSFR or a G-CSF-binding portion thereof and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: June 14, 2016
    Assignee: CSL LIMITED
    Inventors: Brent Steven McKenzie, Peter Frederick Curwen, Eugene Maraskovsky
  • Treatment of neurological conditions
    Patent number: 9352038
    Abstract: The present invention is directed to a method for treating an inflammatory neurodegenerative condition of the CNS in a subject comprising administering to said subject a G-CSF or G-CSFR inhibiting agent selected from the group consisting of an antibody specific for G-CSF, a soluble G-CSFR or a G-CSF-binding portion thereof and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: May 31, 2016
    Assignee: CSL LIMITED
    Inventors: Brent Steven McKenzie, Peter Frederick Curwen, Eugene Maraskovsky
  • Method of treating inflammatory bowel disease
    Patent number: 9211329
    Abstract: A method for treating or preventing an inflammatory bowel disease (IBD) in a subject, the method comprising administering to the subject a compound that inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) signaling.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 15, 2015
    Assignee: CSL LIMITED
    Inventors: Brent McKenzie, Eugene Maraskovsky
  • COMPOSITIONS AND METHODS FOR TARGETING TYPE 1 INTERFERON PRODUCING CELLS
    Publication number: 20150147322
    Abstract: The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor ? (IL-3R?) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
    Type: Application
    Filed: February 9, 2015
    Publication date: May 28, 2015
    Inventors: Gino Luigi VAIRO, Andrew NASH, Eugene MARASKOVSKY, Nick WILSON, Samantha BUSFIELD, Con PANOUSIS
  • ANTI-TUMOR COMPOSITIONS AND USES THEREOF
    Publication number: 20150037374
    Abstract: The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.
    Type: Application
    Filed: July 30, 2014
    Publication date: February 5, 2015
    Inventors: Adriana BAZMORELLI, Eugene MARASKOVSKY
  • Immunotherapeutic method involving CD123 (IL-3R?) antibodies and immunostimulating complex
    Patent number: 8920803
    Abstract: A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3R?(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: December 30, 2014
    Assignee: CSL Limited
    Inventors: Debra Pauline Drane, Eugene Maraskovsky, Jefferey Stephen Boyle
  • TREATMENT OF NEUROLOGICAL CONDITIONS
    Publication number: 20140234303
    Abstract: The present invention is directed to a method for treating an inflammatory neurodegenerative condition of the CNS in a subject comprising administering to said subject a G-CSF or G-CSFR inhibiting agent selected from the group consisting of an antibody specific for G-CSF, a soluble G-CSFR or a G-CSF-binding portion thereof and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF.
    Type: Application
    Filed: March 24, 2014
    Publication date: August 21, 2014
    Applicant: CSL LIMITED
    Inventors: Brent Steven McKenzie, Peter Frederick CURWEN, Eugene MARASKOVSKY
  • COMPOSITIONS AND METHODS FOR TARGETING TYPE 1 INTERFERON PRODUCING CELLS
    Publication number: 20140178364
    Abstract: The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor ? (IL-3R?) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
    Type: Application
    Filed: August 14, 2013
    Publication date: June 26, 2014
    Applicant: CSL Limited
    Inventors: Gino Luigi VAIRO, Andrew NASH, Eugene MARASKOVSKY, Nick WILSON, Samantha BUSFIELD
  • Receptor activator of NF-kappaB
    Patent number: 8569456
    Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: October 29, 2013
    Assignee: Immunex Corporation
    Inventors: Dirk M Anderson, Laurent Galibert, Eugene Maraskovsky
  • Methods of treating lupus by administering humanized anti-interleukin 3 receptor alpha chain antibodies
    Patent number: 8535669
    Abstract: The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor ? (IL-3R?) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: September 17, 2013
    Assignee: CSL Limited
    Inventors: Gino Luigi Vairo, Andrew Nash, Eugene Maraskovsky, Nick Wilson, Samantha Busfield
  • METHOD OF TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20130164291
    Abstract: A method for treating or preventing an inflammatory bowel disease (IBD) in a subject, the method comprising administering to the subject a compound that inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) signaling.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 27, 2013
    Applicant: CSL Limited
    Inventors: Brent MCKENZIE, Eugene MARASKOVSKY