Patents by Inventor Eugene Mash
Eugene Mash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220211854Abstract: The present invention provides a nitroreductase-releasable pro-drug of the formula: where Ar1, m, n, Z, Y, L, and A are as defined herein, and methods for using and producing the same. Compound of formula I is useful in oral administration of the active pharmaceutical ingredient to the distal gut region of a subject to treat a wide variety of clinical conditions associated with distal gut region of a subject, such as colorectal cancer, inflammatory bowel disease (IBD), infectious diarrhea, bacterial infections, and bacterial overgrowth.Type: ApplicationFiled: April 6, 2020Publication date: July 7, 2022Applicant: Arizona Board of Regents on Behalf of the University of Arizona, a body corporateInventors: Eugene A. MASH, Pawel R. KIELA
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Publication number: 20220001038Abstract: Disclosed are anti-cancer compounds and imaging agents. More specifically, the disclosed agents target carbonic anhydrase IX and XII and their use in the treatment of cancer, in particular breast cancer. Specific compounds are those that have Formula II wherein R1 and R2 are each independently chosen from (CH2)nC?CH and, L is a linking moiety; n is 1-8; m is 0-8; each X is independently chosen from R3, OR3, NH2, NHR3, and; and each R3 is independently chosen from a detectable moiety or targeting moiety, with the proviso that R1 and R2 are not both (CH2)4C?CH.Type: ApplicationFiled: June 21, 2018Publication date: January 6, 2022Inventors: David L. Morse, Eugene A. Mash, M. Catherine Lee
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Patent number: 11207429Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.Type: GrantFiled: May 11, 2015Date of Patent: December 28, 2021Assignee: Arizona Board of Regents on behalf of the University of ArizonaInventors: Eugene A. Mash, Parastou Foroutan, Suryakiran Navath, Robert J. Gillies, Gary V. Martinez, David L. Morse
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Patent number: 10717700Abstract: The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (—NO2) groups.Type: GrantFiled: January 18, 2016Date of Patent: July 21, 2020Assignee: Arizona Board of Regents on behalf of the University of ArizonaInventors: Bhumasamudram Jagadish, Eugene Mash
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Publication number: 20180179144Abstract: The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (—NO2) groups.Type: ApplicationFiled: January 18, 2016Publication date: June 28, 2018Applicant: Arizona Board of Regents for the University of ArizonaInventors: Bhumasamudram Jagadish, Eugene Mash
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Publication number: 20170209602Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.Type: ApplicationFiled: May 11, 2015Publication date: July 27, 2017Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, H. Lee Moffitt Cancer Center and Research InstituteInventors: Eugene A. Mash, Parastou Foroutan, Navath Suryakiran, Robert J. Gillies, Gary V. Martinez, David L. Morse
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Publication number: 20160346399Abstract: The present invention provides a composition comprising a disaccharide where at least one of the hydroxyl groups of the disaccharide is attached to a linker. The terminal portion of the linker also includes a drug that is attached via a functional group that is capable of releasing the drug in vivo. Compositions of the invention are useful for delivering the drug at or near inter alia lower GI tract. In some embodiments, compositions of the invention are used for, but not limited to, treating diseases of the colon, and in particular, inflammatory bowel disease, microscopic colitis, and eosinophilic colitis.Type: ApplicationFiled: August 10, 2016Publication date: December 1, 2016Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Eugene A. Mash, Pawel R. Kiela, Fayez K. Ghishan
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Patent number: 9415110Abstract: A composition and method for targeted delivery of substances to the lower GI tract comprises a base or scaffold carrier to which a drug or prodrug is fixed or covalently attached. Compound, when taken orally travels through the GI tract of a patient to the lower GI where bacterial azo reductace enzymes cleave the bonds, releasing the drug or prodrug from the base or scaffold carrier permitting the delivery of the drug to the vicinity of a target cell type in the GI tract. The base or scaffold, which remains as a by-product passes out of the GI tract in the feces.Type: GrantFiled: May 6, 2014Date of Patent: August 16, 2016Assignee: The Arizona Board of Regents on behalf of the Univeristy of ArizonaInventors: Eugene A. Mash, Jr., Pawel R. Kiela, Fayez K. Ghishan
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Patent number: 9320734Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: GrantFiled: January 5, 2015Date of Patent: April 26, 2016Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on behalf of the University of ArizonaInventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
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Publication number: 20150126563Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: ApplicationFiled: January 5, 2015Publication date: May 7, 2015Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Arizona Board of Regents on Behalf of the University of ArizonaInventors: Daruka MAHADEVAN, Emmanuelle J. MEUILLET, Eugene A. MASH, JR., Vijay M. GOKHALE, Garth POWIS, Shuxing ZHANG
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Patent number: 8962663Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: GrantFiled: March 7, 2013Date of Patent: February 24, 2015Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of ArizonaInventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
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Patent number: 8420678Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: GrantFiled: April 14, 2009Date of Patent: April 16, 2013Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of ArizonaInventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gohkale, Garth Powis, Shuxing Zhang
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Publication number: 20110144066Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: ApplicationFiled: April 14, 2009Publication date: June 16, 2011Applicants: The Board of Regents of the University of Texas System, Arizona Board of Regents on Behalf of the University of ArizonaInventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Vijay Gokhale, Garth Powis, Shuxing Zhang
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Patent number: 5958966Abstract: Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing of vascular grafts for transplantation; are provided.Type: GrantFiled: June 5, 1995Date of Patent: September 28, 1999Assignee: University of New MexicoInventors: Paul L. Mann, Eugene Mash, Terence J. Scallen
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Patent number: 5919464Abstract: Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing of vascular grafts for transplantation; are provided.Type: GrantFiled: September 23, 1993Date of Patent: July 6, 1999Assignee: University of New MexicoInventors: Paul L. Mann, Eugene Mash