Patents by Inventor Eugene Michal
Eugene Michal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9561309Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: May 27, 2004Date of Patent: February 7, 2017Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Eugene Michal, Charles Claude, Stephen D. Pacetti
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Patent number: 9149602Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.Type: GrantFiled: April 22, 2005Date of Patent: October 6, 2015Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Mina Chow, Dwight A. Ambat, Jin Cheng, Eugene Michal
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Patent number: 9101697Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: GrantFiled: April 11, 2014Date of Patent: August 11, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Publication number: 20150216563Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.Type: ApplicationFiled: February 9, 2015Publication date: August 6, 2015Inventors: Evgenia Mandrusov, Albert K. Chin, William Earl Webler, JR., Yan Shen, Robert D. Ainsworth, Eugene Michal
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Patent number: 8968991Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.Type: GrantFiled: February 15, 2008Date of Patent: March 3, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Evgenia Mandrusov, Albert K. Chin, William Earl Webler, Jr., Yan Shen, Robert D. Alnsworth, Eugene Michal
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Patent number: 8906394Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: GrantFiled: September 28, 2012Date of Patent: December 9, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Patent number: 8846836Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: GrantFiled: September 28, 2012Date of Patent: September 30, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Thierry Glauser, Syed Faiyaz Ahmed Hossainy, Connie Kwok, Stephen Dirk Pacetti, Eugene Michal
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Publication number: 20140221418Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Patent number: 8734817Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: GrantFiled: September 28, 2012Date of Patent: May 27, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Patent number: 8609126Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.Type: GrantFiled: May 25, 2012Date of Patent: December 17, 2013Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene Michal, Shubhayu Basu, Hai-Chien Kuo
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Patent number: 8486386Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.Type: GrantFiled: April 7, 2010Date of Patent: July 16, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu
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Patent number: 8486387Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.Type: GrantFiled: April 7, 2010Date of Patent: July 16, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu
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Patent number: 8377033Abstract: A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.Type: GrantFiled: September 8, 2010Date of Patent: February 19, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Randolf von Oepen, Eugene Michal, Florian Ludwig
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Patent number: 8293890Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: GrantFiled: April 30, 2004Date of Patent: October 23, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Publication number: 20120237477Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.Type: ApplicationFiled: May 25, 2012Publication date: September 20, 2012Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Eugene Michal, Shubhayu Basu, Hai-Chien Kuo
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Patent number: 8187621Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.Type: GrantFiled: June 5, 2006Date of Patent: May 29, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene Michal, Shubhayu Basu, Hai-Chien Kuo
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Publication number: 20120059355Abstract: A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.Type: ApplicationFiled: September 8, 2010Publication date: March 8, 2012Applicant: Abbott Cardiovascular Systems, Inc.Inventors: Shubhayu Basu, Randolf von Oepen, Eugene Michal, Florian Ludwig
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Patent number: 8038991Abstract: Embodiments of single component bioscaffolding systems formed of a hydrogel such as hyaluronic acid or salt thereof are described. The hyaluronic acid or salt thereof may be dissolved in a buffer, plasma, or combination thereof to minimize adverse immunogenic responses when applied to a treatment site. Additionally, the hydrogel component includes stem cells to facilitate angiogenesis or facilitate tissue repair and/or regeneration of ischemic tissue, particularly in compromised cardiac tissue. The bioscaffolding may also be formed on a stent or a cardiac medical device.Type: GrantFiled: November 1, 2007Date of Patent: October 18, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: John J. Stankus, Eugene Michal, Mikael Trollsas, Brandon Katz, Shubhayu Basu
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Publication number: 20100196313Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.Type: ApplicationFiled: April 7, 2010Publication date: August 5, 2010Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu
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Publication number: 20100196314Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.Type: ApplicationFiled: April 7, 2010Publication date: August 5, 2010Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu