Patents by Inventor Eugene Paul Kroeff

Eugene Paul Kroeff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of Echinocandin cyclopeptide compounds
    Patent number: 6506726
    Abstract: A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amino group (including the deacylated Echinocandin-type compounds) from their fermentation or mixed broths and partially purified process streams by adsorbing the mixture onto a hydrophobic, reversed phase chromatographic media and eluting with a continuous linear acetic acid gradient ranging from 0.1% acetic acid to 10.0% acetic acid by volume in water. A process for removing tripeptide-aldehyde by-products from the fermentation products by means of a derivatizing agent is also described.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: January 14, 2003
    Assignee: Eli Lilly and Company
    Inventors: John Robert Dobbins, Eugene Paul Kroeff, Jeffrey Thomas Vicenzi