Abstract: Methods, protocols and systems are provided for multi-modality imaging based on pharmacokinetics of an imaging agent. An imaging agent is introduced into a subject, and is permitted to collect generally in a region of interest (ROI) in the subject until attaining a pseudo-steady state (PSS) distribution within the ROI. The imaging agent records a first functional state of the ROI at a given point in time. A first image data set is obtained with a first imaging modality during a first acquisition time interval that occurs prior or proximate in time with the PSS time interval. The subject is transferred from the first imaging modality to a second imaging modality during a transfer time interval that overlaps the PSS time interval. Once transfer is complete, a second image data set is obtained with the second imaging modality during a second acquisition time interval that also overlaps the PSS time interval in which the imaging agent maintains the PSS distribution in the ROI.

Abstract: Configurations for stationary imaging systems are provided. The configurations may include combinations of various types of distributed sources of X-ray radiation, which generally include addressable emitter elements which may be triggered for emission in desired sequences and combinations. The sources may be ring-like, partial ring-like, or line-like (typically along a Z-axis), and so forth. Combinations of these are envisaged. Corresponding detectors may also be full ring detectors or partial ring detectors associated with the sources to provide sufficient coverage of imaging volumes and to provide the desired mathematical completeness of the collected data.