Patents by Inventor Eugene Tan
Eugene Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240336918Abstract: Provided are methods of inhibiting activity of a RNA binding protein in a cell that include (a) generating a RNA binding N protein (RBP) binding agent comprising an RNA molecule comprising a binding site for the RNA binding protein; and (b) delivering the RBP binding agent into the cell, wherein the RBP binding agent binds to the RNA binding protein, thereby inhibiting the activity of the RNA binding protein in the cell.Type: ApplicationFiled: July 8, 2022Publication date: October 10, 2024Inventors: Eugene Yeo, Frederick Tan
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Publication number: 20240198457Abstract: A system for cutting composite sheets from a composite panel in a high throughout manner is disclosed. The system comprises a platform; a displacement module; a cutting module located for slicing a plurality of the composite sheets from the composite panel, by way of heating the composite panel at specific locations using a laser beam generated from a laser, each composite sheet having a contour profile; a placing module for picking a number of the sliced composite sheets and arranging the picked composite sheets onto one of multiple inspection slots located on a rotary surface; and an inspection module comprising at least two cameras each being enabled to capture a digital image of the contour profile of at least one composite sheet at one of the inspection spots and a computing device to process the digital image for a computing device to analyse the contour profile using a set of predefined parameters.Type: ApplicationFiled: December 16, 2022Publication date: June 20, 2024Inventors: Sia Nguan Eugene TAN, Song Tao LI
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Patent number: 11900604Abstract: Described herein is an adaptive expert system comprising a computing device having a memory that stores programmatic instructions and a processor that executes the programmatic instructions. The adaptive expert system receives sample data comprising at least one of raw data, optical data, and electropherogram data from a DNA analysis device, said data generated from a sample containing DNA. The adaptive expert system determines at least one characteristic of the sample data. The adaptive expert system utilizes the at least one characteristic to classify the sample data and apply a predefined parameter set to the said sample data to generate an output.Type: GrantFiled: July 12, 2018Date of Patent: February 13, 2024Assignee: ANDE CorporationInventors: Eugene Tan, Hua Jiang, Richard F. Selden
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Publication number: 20230394665Abstract: Described herein is an adaptive expert system comprising a computing device having a memory that stores programmatic instructions and a processor that executes the programmatic instructions. The adaptive expert system receives sample data comprising at least one of raw data, optical data, and electropherogram data from a DNA analysis device, said data generated from a sample containing DNA. The adaptive expert system determines at least one characteristic of the sample data. The adaptive expert system utilizes the at least one characteristic to classify the sample data and apply a predefined parameter set to the said sample data to generate an output.Type: ApplicationFiled: August 17, 2023Publication date: December 7, 2023Applicant: Ande CorporationInventors: Eugene Tan, Hua Jiang, Richard F. Selden
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Publication number: 20230256451Abstract: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.Type: ApplicationFiled: February 21, 2023Publication date: August 17, 2023Inventors: Richard F. Selden, Eugene Tan
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Patent number: 11612893Abstract: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.Type: GrantFiled: December 2, 2016Date of Patent: March 28, 2023Assignee: ANDE CORPORATIONInventors: Richard F. Selden, Eugene Tan
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Patent number: 11612894Abstract: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.Type: GrantFiled: January 26, 2017Date of Patent: March 28, 2023Assignee: ANDE CORPORATIONInventors: Richard F. Selden, Eugene Tan
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Publication number: 20220389487Abstract: Described herein are instruments for excitation and detection of fluorophores in a plurality of functional regions in a biochip, using an excitation source and a steering element that directs a beam from the excitation source to a plurality of functional regions in the biochip, wherein the excitation source excites the fluorophores in the plurality of functional regions generating a signal that is detected such that said signal from at least one of the plurality of functional regions allows for nucleic acid quantification. Also described are systems for quantification and separation and detection using optical devices adapted for preliminary, simultaneous or sequential quantitation of nucleic acid in separate detection positions, and for the excitation and detection of multiple samples to steer both the excitation and detection beam paths to separately image each lane of a biochip.Type: ApplicationFiled: August 8, 2022Publication date: December 8, 2022Applicant: ANDE CorporationInventors: Eugene Tan, Richard F. Selden, Rosemary S. Turingan
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Publication number: 20220315996Abstract: Described herein are methods and devices for nucleic acid quantification and, in particular, to microfluidic methods and devices for nucleic acid quantification. In certain embodiments methods of quantifying a target nucleic acid without the need for amplification are provided. The methods involve, in some embodiments, allowing a binding agent to become immobilized with respect to the target nucleic acid. In some cases, the binding agent comprises a signaling moiety that can be used to quantify the amount of target nucleic acid. In another aspect, the quantification can be carried out rapidly. For example, in certain embodiments, the quantification can be completed within 5 minutes. In yet another aspect, samples containing a low amount of target nucleic acid can be quantified. For instance, in some cases, samples containing less than 100 nanograms per microliter may be quantified. Also described are devices and kits for performing such methods, or the like.Type: ApplicationFiled: June 9, 2022Publication date: October 6, 2022Applicant: ANDE CORPORATIONInventors: Eugene Tan, Richard F. Selden, Rosemary S. Turingan
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Patent number: 11441173Abstract: Described herein are instruments for excitation and detection of fluorophores in a plurality of functional regions in a biochip, using an excitation source and a steering element that directs a beam from the excitation source to a plurality of functional regions in the biochip, wherein the excitation source excites the fluorophores in the plurality of functional regions generating a signal that is detected such that said signal from at least one of the plurality of functional regions allows for nucleic acid quantification. Also described are systems for quantification and separation and detection using optical devices adapted for preliminary, simultaneous or sequential quantitation of nucleic acid in separate detection positions, and for the excitation and detection of multiple samples to steer both the excitation and detection beam paths to separately image each lane of a biochip.Type: GrantFiled: December 27, 2019Date of Patent: September 13, 2022Assignee: ANDE CORPORATIONInventors: Eugene Tan, Richard F. Selden, Rosemary S. Turingan
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Patent number: 11445614Abstract: The disclosed system generally comprises a damping module, a pressing module, a placement platform for placement of the multiple stacked planar objects and a compensatory mechanism engaging to the damping module. Particularly, the damping module includes a damper, a resilient component and an elongate support which are all arranged within a holder. Each of the stacked planar objects has a top planar surface and an underside planar surface as well as carries a plurality of corresponding holes, which become aligned accordingly to form a plurality of longitudinal grooves upon placement onto the platform. The head portion of the damper is substantially aligning with the positioned groove and abutting onto the underside surface of the bottommost stacked object. The compensatory mechanism is capable of adaptively adjusting position of the head portion of the damper in relation to the pressing ram at the vertical and/or horizontal plane.Type: GrantFiled: April 24, 2019Date of Patent: September 13, 2022Assignees: JLK Technology Pte Ltd, JLK Automation (Dongguan) Co. LtdInventors: Sia Nguan Eugene Tan, Song Tao Li
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Patent number: 11110461Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.Type: GrantFiled: February 12, 2018Date of Patent: September 7, 2021Assignee: ANDE CORPORATIONInventors: Eugene Tan, Heung Chuan Lam, Valery Leonidovich Bogdanov, Gregory John Kellogg, John A. Wright, Ulrich Hans Thomann, Richard F. Selden
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Patent number: 11052398Abstract: Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.Type: GrantFiled: June 7, 2018Date of Patent: July 6, 2021Assignee: ANDE CORPORATIONInventors: Eugene Tan, Cheuk Wai Kan, Heung Chuan Lam
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Patent number: 11022555Abstract: Provided are methods for multiplex polymerase chain reaction (PCR) amplification of short tandem repeat (STR) loci that can be used to rapidly generate a highly specific STR profile from target nucleic acids. The resulting STR profiles are useful for human identification purposes in law enforcement, homeland security, military, intelligence, and paternity testing applications.Type: GrantFiled: October 16, 2017Date of Patent: June 1, 2021Assignee: ANDE CORPORATIONInventors: James W. Schumm, Richard F. Selden, Eugene Tan
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Patent number: 10821445Abstract: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.Type: GrantFiled: May 2, 2016Date of Patent: November 3, 2020Assignee: ANDE CorporationInventors: Richard F. Selden, Eugene Tan
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SYSTEM AND METHOD FOR FASTENING MULTIPLE STACKED PLANAR OBJECTS WITH ADAPTIVE COMPENSATORY MECHANISM
Publication number: 20200344887Abstract: The disclosed system generally comprises a damping module, a pressing module, a placement platform for placement of the multiple stacked planar objects and a compensatory mechanism engaging to the damping module. Particularly, the damping module includes a damper, a resilient component and an elongate support which are all arranged within a holder. Each of the stacked planar objects has a top planar surface and an underside planar surface as well as carries a plurality of corresponding holes, which become aligned accordingly to form a plurality of longitudinal grooves upon placement onto the platform. The head portion of the damper is substantially aligning with the positioned groove and abutting onto the underside surface of the bottommost stacked object. The compensatory mechanism is capable of adaptively adjusting position of the head portion of the damper in relation to the pressing ram at the vertical and/or horizontal plane.Type: ApplicationFiled: April 24, 2019Publication date: October 29, 2020Inventors: Sia Nguan Eugene TAN, Song Tao LI -
Publication number: 20200248243Abstract: Described herein are instruments for excitation and detection of fluorophores in a plurality of functional regions in a biochip, using an excitation source and a steering element that directs a beam from the excitation source to a plurality of functional regions in the biochip, wherein the excitation source excites the fluorophores in the plurality of functional regions generating a signal that is detected such that said signal from at least one of the plurality of functional regions allows for nucleic acid quantification. Also described are systems for quantification and separation and detection using optical devices adapted for preliminary, simultaneous or sequential quantitation of nucleic acid in separate detection positions, and for the excitation and detection of multiple samples to steer both the excitation and detection beam paths to separately image each lane of a biochip.Type: ApplicationFiled: December 27, 2019Publication date: August 6, 2020Inventors: Eugene Tan, Richard F. Selden, Rosemary S. Turingan
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Publication number: 20200215544Abstract: A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a macrofluidic component, including a chamber for receiving an unprocessed sample from a collection device and at least one filled liquid purification reagent storage reservoir; and (ii) a microfluidic component in communication with the macrofluidic component through at least one microfluidic element, the microfluidic component further comprising at least one nucleic acid purification matrix; and (iii) at least one interface port to a drive mechanism on the instrument for driving said liquid purification reagent, through the microfluidic element and the nucleic acid purification matrix, wherein the only inputs to the apparatus are through the chamber and the interface port to the drive mechanism.Type: ApplicationFiled: October 7, 2019Publication date: July 9, 2020Inventors: Richard F. Selden, Eugene Tan
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Patent number: 10638749Abstract: A disinfestation article includes a base, external voids and internal voids formed in the base, pesticidal compound disposed in the external and internal voids. The pesticidal compound disposed in the external void being exposed to a surface of the base. The article may further comprise channels connecting one of the internal voids to one of the external voids. The pesticidal compound contains pesticidal particles selected from pyrethroid family or the like. Also claimed is a method of manufacturing which includes mixing pesticidal particles into a molten polymer material to form a mixture, injecting the mixture into a mold to form a molded part, and cooling the molded part to form said disinfestation article.Type: GrantFiled: May 7, 2018Date of Patent: May 5, 2020Inventor: Dong Lin Eugene Tan
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Publication number: 20200070173Abstract: A fast, multiplexed PCR system is described that can rapidly generate amplified nucleic acid products, for example, a full STR profile, from a target nucleic acid. Such systems include, for example, microfluidic biochips and a custom built thermal cycler, which are also described. The resulting STR profiles can satisfy forensic guidelines for signal strength, inter-loci peak height balance, heterozygous peak height ratio, incomplete non-template nucleotide addition, and stutter.Type: ApplicationFiled: May 14, 2019Publication date: March 5, 2020Inventors: Richard F. Selden, Eugene Tan, Heung Chuan Lam, Heidi Susanne Giese, Gregory John Kellogg, John A. Wright