Patents by Inventor Eugene Tkachenko

Eugene Tkachenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sealed microwell assay
    Patent number: 11969702
    Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: April 30, 2024
    Assignees: Celldom, Inc., The Regents of the University of California
    Inventors: Natalia Tkachenko, Eugene Tkachenko, Alexander Groisman, Edgar Gutierrez
  • DEVICE AND METHOD FOR CELL-BASED DRUG SCREENING
    Publication number: 20240060961
    Abstract: Provided are methods and compositions for cell-based drug screening with high-density arrays of conical microwells and slow-drug-release beads.
    Type: Application
    Filed: October 30, 2023
    Publication date: February 22, 2024
    Inventors: Eugene Tkachenko, Natalia Tkachenko, Edgar Gutierrez, Alexander Groisman
  • DEVICE AND METHOD FOR CELL-BASED DRUG SCREENING
    Publication number: 20190137481
    Abstract: Provided are methods and compositions for cell-based drug screening with high-density arrays of conical microwells and slow-drug-release beads.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 9, 2019
    Inventors: Eugene Tkachenko, Natalia Tkachenko, Edgar Gutierrez, Alexander Groisman
  • Microfluidic system and method for using same
    Patent number: 8372358
    Abstract: In a microfluidic system, a magnetic clamp for sealing a flexible microchannel chip includes a base formed from a magnetically-attractable material. The base supports a window for viewing the face of the microfluidic chip. A ring with magnets uniformly distributed around it is disposed over the base. A transparent disk attached to the top of the ring has an inlet and an outlet for introducing and removing a fluid medium into a cavity defined the disk, the window, the center opening of the ring and the base. An elastomer cushion is attached to the inner surface of the disk. The magnetic force between the base and the magnets on the ring compresses the cushion against the microfluidic chip so that the microchannels are sealed against the window with a uniform and reproducible pressure.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: February 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Alexander Groisman, Edgar Gutierrez, Eugene Tkachenko, Mark H. Ginsberg
  • MICROFLUIDIC SYSTEM AND METHOD FOR USING SAME
    Publication number: 20110044865
    Abstract: In a microfluidic system, a magnetic clamp for sealing a flexible microchannel chip includes a base formed from a magnetically-attractable material. The base supports a window for viewing the face of the microfluidic chip. A ring with magnets uniformly distributed around it is disposed over the base. A transparent disk attached to the top of the ring has an inlet and an outlet for introducing and removing a fluid medium into a cavity defined the disk, the window, the center opening of the ring and the base. An elastomer cushion is attached to the inner surface of the disk. The magnetic force between the base and the magnets on the ring compresses the cushion against the microfluidic chip so that the microchannels are sealed against the window with a uniform and reproducible pressure.
    Type: Application
    Filed: August 23, 2010
    Publication date: February 24, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Alexander Groisman, Edgar Gutierrez, Eugene Tkachenko, Mark H. Ginsberg