Patents by Inventor Eugene Trybulski
Eugene Trybulski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080119537Abstract: Compounds of formula I or II and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I, formula II, or formula III.Type: ApplicationFiled: November 16, 2007Publication date: May 22, 2008Applicant: WyethInventors: Puwen Zhang, Jeffrey Kern, Eugene Terefenko, Eugene Trybulski
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Publication number: 20070072918Abstract: The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: September 27, 2006Publication date: March 29, 2007Applicant: WyethInventors: Casey McComas, Puwen Zhang, Eugene Trybulski, An Vu, Eugene Terefenko
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Publication number: 20070072897Abstract: The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.Type: ApplicationFiled: September 27, 2006Publication date: March 29, 2007Applicant: WyethInventors: Paige Mahaney, Gavin Heffernan, Richard Coghlan, Stephen Cohn, Callain Kim, Douglas Jenkins, Michael Marella, Casey McComas, Joseph Sabatucci, Eugene Terefenko, Eugene Trybulski, An Vu, Fei Ye, Puwen Zhang
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Publication number: 20070066628Abstract: Compounds of formula I are provided, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R3-R5, R10, and R11 are defined herein.Type: ApplicationFiled: September 18, 2006Publication date: March 22, 2007Applicant: WyethInventors: Puwen Zhang, Jeffrey Kern, Eugene Terefenko, Eugene Trybulski
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Publication number: 20070066637Abstract: Compounds of formula I, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R3-R5, R10, and R11 are defined herein.Type: ApplicationFiled: September 18, 2006Publication date: March 22, 2007Applicant: WyethInventors: Puwen Zhang, Jeffrey Kern, Eugene Terefenko, Eugene Trybulski
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Publication number: 20070066675Abstract: Compounds of formula I or II are provided, wherein R1—R8 are defined herein, and pharmaceutical compositions and kits containing these compounds. Also provides are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I, formula II, or formula III, wherein R2—R4 and R9 are defined herein.Type: ApplicationFiled: September 18, 2006Publication date: March 22, 2007Applicant: WyethInventors: Puwen Zhang, Jeffrey Kern, Eugene Terefenko, Eugene Trybulski
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Publication number: 20060287522Abstract: This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).Type: ApplicationFiled: June 8, 2006Publication date: December 21, 2006Applicant: WYETHInventors: Amedeo Failli, Gavin Heffernan, Arthur Santilli, Dominick Quagliato, Richard Coghlan, Patrick Andrae, Susan Croce, Emily Shen, Eugene Trybulski
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Publication number: 20060276456Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heteType: ApplicationFiled: August 11, 2006Publication date: December 7, 2006Applicant: WyethInventors: Kevin Memoli, Amedeo Failli, Thomas Caggiano, Jay Shumsky, Eugene Trybulski, John Dusza
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Publication number: 20060154875Abstract: This invention provides estrogen receptor modulators having the structure: wherein R1 to R7 are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 20, 2005Publication date: July 13, 2006Applicant: WyethInventors: Richard Coghlan, William Fobare, Eugene Trybulski
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Publication number: 20060058337Abstract: The present invention relates generally to phenanthridine carbonyl compositions such as substituted phenanthridine carbonyl phenols and methods of using them.Type: ApplicationFiled: August 30, 2005Publication date: March 16, 2006Applicant: WYETHInventors: Robert Steffan, William Moore, Eugene Trybulski, Albert Molinari
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Publication number: 20060020003Abstract: The present invention relates generally to substituted biphenyloxy acids (such as 4?-aryl-amido-biphenyl-4(3)-yloxy-acids and 4?-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them.Type: ApplicationFiled: September 23, 2004Publication date: January 26, 2006Applicant: WYETHInventors: Thomas Commons, Susan Croce, Eugene Trybulski, Hassan Elokdah, David Crandall
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Publication number: 20050234058Abstract: The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: October 12, 2004Publication date: October 20, 2005Applicant: WyethInventors: Paige Mahaney, Michael Webb, Lori Gavrin, Eugene Trybulski
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Publication number: 20050222148Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: March 28, 2005Publication date: October 6, 2005Applicant: WyethInventors: Callain Kim, Paige Mahaney, Eugene Trybulski, Puwen Zhang, Eugene Terefenko, Casey McComas, Michael Marella, Richard Coghlan, Gavin Heffernan, Stephen Cohn, An Vu, Joseph Sabatucci, Fei Ye
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Publication number: 20050192283Abstract: The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: October 12, 2004Publication date: September 1, 2005Applicant: WyethInventors: Eugene Trybulski, Paige Mahaney, Lori Gavrin, Joseph Sabatucci, Gary Stack
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Publication number: 20050171115Abstract: The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: October 12, 2004Publication date: August 4, 2005Applicant: WyethInventors: Eugene Trybulski, Paige Mahaney, Lori Gavrin, William Moore, Joseph Sabatucci
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Publication number: 20050143579Abstract: The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: October 12, 2004Publication date: June 30, 2005Applicant: WyethInventors: Eugene Trybulski, Joseph Sabatucci, An Vu, Stephen Cohn, Arthur Santilli, Lori Gavrin, Fei Ye, Paige Mahaney
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Publication number: 20050143394Abstract: The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: ApplicationFiled: October 12, 2004Publication date: June 30, 2005Applicant: WyethInventors: Paige Mahaney, Eugene Trybulski, Lori Gavrin, An Vu
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Publication number: 20050075328Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heType: ApplicationFiled: November 4, 2004Publication date: April 7, 2005Applicant: WyethInventors: Amedeo Failli, John Dusza, Thomas Caggiano, Jay Shumsky, Kevin Memoli, Eugene Trybulski
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Patent number: 5478939Abstract: Compounds of the Formulae I or II ##STR1## wherein Z and R.sub.1, are as described herein which compounds are muscarinic agonists useful in treating central cholinergic disfunction and pharmaceutical compositions containing the compounds.Type: GrantFiled: July 20, 1994Date of Patent: December 26, 1995Assignee: American Cyanamid CompanyInventors: Eugene Trybulski, Jing Zhang