Abstract: Recombinant detargeted and retargeted adenovirus viral particles and vectors are provided. In particular, modified fibers from adenoviruses that bind to coxsackie-adenovirus receptor (CAR) in vivo that contain modifications in the fiber shaft are provided. Adenovirus (Ad) particles that express such fibers exhibit reduced binding to CAR. Hence detargeted Ad particles are provides; also provided are retargeted particles.

Abstract: A device and method for treating cardiac ischemia with vagal stimulation is disclosed. In one embodiment, an implantable device is configured to deliver vagal stimulation upon obtaining an indication of cardiac ischemia by analysis of a recorded electrogram.

Abstract: A miniature WDM add/drop multiplexer and its manufacture is described. The device has a plurality of wavelength-dependent filters in the form of thin-film filters mounted to a core frame with the end sections of the input/output optical fiber and other optical fibers associated with each of the filters. The stresses associated with the filters are accounted for. The core frame is sealed, together with the overall package assembly, to provide for long-term reliability of the device. The described device and method of manufacture is also generally applicable to WDM multiplexers and demultiplexers.