Patents by Inventor Eugene Y. Chan

Eugene Y. Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10918290
    Abstract: An integrated vitals device capable of acquiring multiple data streams, allowing for comprehensive measurement of whole health status using a single, compact device. This allows for simplification of traditional healthcare delivery where multiple devices are required for acquisition of vital signs. A sensor stack up, occupying the approximate physical footprint and volume allows this approach to be possible. This application describes how these simultaneous vitals data streams can be acquired using an integrated device with small mass and volume.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: February 16, 2021
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Dexter Eames, Marcus Atkin
  • Patent number: 10449537
    Abstract: A system for collection and delivery of sub-milliliter liquid samples is described that provides a dramatic simplification for the measurement of clinical values. The system produces high dilutions of capillary size samples, such as bodily fluids or blood, by a factor of 1000 or more. Multiple assays can be conducted on a sample of 0.1 cc or less. A small lancet can create a drop of blood on a fingertip or other location, which can be collected into a self-priming capillary blood collector. The sample is then loaded into a consumable loader. Then a fluid, such as saline, is flowed into the consumable loader, and passes through the capillary collector, washing out the fluid. Downstream, the blood in the capillary is reliably diluted by mixing with appropriate reagents to allow analysis of selected blood properties. One or more individual bubbles can be inserted into the stream during loading. The capillary loading system can be used for one or several assays on a single blood sample.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: October 22, 2019
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Julia Z. Sharpe, Eugene Y. Chan
  • Publication number: 20190265262
    Abstract: A sample consumable that carries a microvolume of sample to a sample loader. The consumable is precisely aligned utilizing a double-alignment feature to the loader. The loader is based on a crank-slider geometry and allows for simple, one-handed operation for the user. Overall, the consumable and sample loader increase reproducibility of in-line sample loading and offers ease-of-use.
    Type: Application
    Filed: January 14, 2019
    Publication date: August 29, 2019
    Inventor: Eugene Y. Chan
  • Patent number: 10392557
    Abstract: The stable and precise incorporation of multiple fluorescent dyes into hydrogel microparticles. The multiple fluorescent dyes, excited with the same source, have distinct fluorescence emission spectra to enable identification of the microparticles. The fluorescent molecules are directly polymerized into the hydrogel matrix or stably incorporated through molecular entanglement. By changing the molar ratios of the fluorescent dyes, different and identifiable microparticles can be synthesized.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: August 27, 2019
    Assignee: DNA Medicine Institute, Inc.
    Inventor: Eugene Y. Chan
  • Patent number: 10302546
    Abstract: Multiplexing microparticles by measurement of particle length and dye. Utilization of length-based measurements in combination with dye concentrations to attain multiplexing for bioassays.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: May 28, 2019
    Inventor: Eugene Y. Chan
  • Publication number: 20190150762
    Abstract: An integrated vitals device capable of acquiring multiple data streams, allowing for comprehensive measurement of whole health status using a single, compact device. This allows for simplification of traditional healthcare delivery where multiple devices are required for acquisition of vital signs. A sensor stack up, occupying the approximate physical footprint and volume allows this approach to be possible. This application describes how these simultaneous vitals data streams can be acquired using an integrated device with small mass and volume.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 23, 2019
    Inventors: Eugene Y. Chan, Dexter Eames, Marcus Atkin
  • Patent number: 10279347
    Abstract: An integrated fluidics module that reduces mass and volume so that it can readily fit inside a compact biomedical instrument. A fluidics module that integrates discrete components (e.g., pump, connectors, tubing, regulator, and valves) reduces mass and volume requirements.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: May 7, 2019
    Assignee: DNA Medicine Institute, Inc.
    Inventor: Eugene Y. Chan
  • Patent number: 10251565
    Abstract: An integrated vitals device capable of acquiring multiple data streams, allowing for comprehensive measurement of whole health status using a single, compact device. This allows for simplification of traditional healthcare delivery where multiple devices are required for acquisition of vital signs. A sensor stack up, occupying the approximate physical footprint and volume allows this approach to be possible. This application describes how these simultaneous vitals data streams can be acquired using an integrated device with small mass and volume.
    Type: Grant
    Filed: April 30, 2016
    Date of Patent: April 9, 2019
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Dexter Eames, Marcus Atkin
  • Patent number: 10180442
    Abstract: A sample consumable that carries a microvolume of sample to a sample loader. The consumable is precisely aligned utilizing a double-alignment feature to the loader. The loader is based on a crank-slider geometry and allows for simple, one-handed operation for the user. Overall, the consumable and sample loader increase reproducibility of in-line sample loading and offers ease-of-use.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: January 15, 2019
    Assignee: DNA Medicine Institute, Inc.
    Inventor: Eugene Y. Chan
  • Publication number: 20180346960
    Abstract: The measurement of Factor Xa (FXa) enzymatic activity using novel fluorogenic peptide substrates that have a C-terminus cleavable fluorophore and optionally the ability to attach to a solid support. Fluorogenic measurements increase sensitivity and flexibility of measurements of enzymatic reactions over traditional absorbance-based approaches. The measurement of FXa generation is applicable to a range of biological reactions.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Inventor: Eugene Y. Chan
  • Patent number: 9835542
    Abstract: An integrated optical block that is highly portable and compact, designed to measure cells and particles.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: December 5, 2017
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Julia Z. Sharpe
  • Patent number: 9745625
    Abstract: Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: August 29, 2017
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventor: Eugene Y. Chan
  • Patent number: 9617383
    Abstract: Synthesis of monodisperse PEG-based microparticles with stable coupling chemistries. Biomolecules are conjugated to monodisperse PEG microparticles using non-amine chemistries, such as sulfhydryl groups, azide, or alkyne-based chemistries.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: April 11, 2017
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Moon Bae
  • Patent number: 9568425
    Abstract: Analytical nanostrips for clinical analysis are improved by using multifunctional coding (“multicoding”) to allow simultaneous identification of the particular assay, the value of the assayed analyte, and a calibration of the analyte. The multicoding layout on the nanostrip minimizes the number of zones that are required for a given assay. Moreover, the nanostrip can be scanned in real time during flow of the nanostrip through a detection beam. This both simplifies the assay and allows for alternative means of coding.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: February 14, 2017
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Moon Z. Chan
  • Publication number: 20160317048
    Abstract: An integrated vitals device capable of acquiring multiple data streams, allowing for comprehensive measurement of whole health status using a single, compact device. This allows for simplification of traditional healthcare delivery where multiple devices are required for acquisition of vital signs. A sensor stack up, occupying the approximate physical footprint and volume allows this approach to be possible. This application describes how these simultaneous vitals data streams can be acquired using an integrated device with small mass and volume.
    Type: Application
    Filed: April 30, 2016
    Publication date: November 3, 2016
    Inventors: Eugene Y. Chan, Dexter Eames, Marcus Atkin
  • Publication number: 20150362499
    Abstract: The stable and precise incorporation of multiple fluorescent dyes into hydrogel microparticles. The multiple fluorescent dyes, excited with the same source, have distinct fluorescence emission spectra to enable identification of the microparticles. The fluorescent molecules are directly polymerized into the hydrogel matrix or stably incorporated through molecular entanglement. By changing the molar ratios of the fluorescent dyes, different and identifiable microparticles can be synthesized.
    Type: Application
    Filed: April 8, 2015
    Publication date: December 17, 2015
    Inventor: Eugene Y. Chan
  • Patent number: 9194780
    Abstract: An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: November 24, 2015
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Moon Z Chan
  • Patent number: D752240
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 22, 2016
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Kee Seok Jeon
  • Patent number: D785781
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 2, 2017
    Assignee: DNA Medicine Institute, Inc.
    Inventor: Eugene Y. Chan
  • Patent number: D814042
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 27, 2018
    Assignee: DNA Medicine Institute, Inc.
    Inventors: Eugene Y. Chan, Marcus Atkin