Abstract: Some representative embodiments are directed to treating chronic pain in a patient. A first stimulation lead is implanted in the patient with electrodes in the epidural space of the patient. A second stimulation lead is implanted with electrodes in subcutaneous tissue in an area of back or torso pain of the patient. The electrodes of the second stimulation lead are disposed in a configuration that is substantially perpendicular to an axis defined by the spine of the patient. Electrical pulses are generated by an implantable pulse generator for application to tissue of the patient. The electrical pulses are applied to the tissue of the patient using electrodes of the first stimulation lead and electrodes of the second stimulation lead. Active electrodes on the first stimulation lead are set to a first polarity and active electrodes on the second stimulation lead are set to a second polarity that is opposite to the first polarity.

Abstract: Compositions of non-racemic mixtures of d- and l-methadone and a method of treating pain using the composition. The composition is especially useful for treating pain of mixed origin. For predominantly neuropathic pain, a mixture of predominantly d-methadone, up to about 90%, is used. For predominantly somatic pain, a mixture of predominantly l-methadone, up to about 90%, is used. The non-racemic mixture of d- and l-methadone may be further combined with a pharmacologically effective amount of a nonopioid component. In another aspect of the invention, the methadone can be combined with an opioid antagonist such as naloxone, naltrexone, or the like.