Patents by Inventor Eugenia Ribeiro de Sousa Fidalgo Leitao

Eugenia Ribeiro de Sousa Fidalgo Leitao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device for incorporation and release of biologically active agents
    Patent number: 6344061
    Abstract: The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: February 5, 2002
    Assignee: IsoTis N.V.
    Inventors: Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai-Bo Wen, Klaas De Groot
  • Device for incorporation and release of biologically active agents
    Patent number: 6143948
    Abstract: The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: November 7, 2000
    Assignee: IsoTis B.V.
    Inventors: Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai-Bo Wen, Klaas De Groot
  • Device for incorporation and release of biologically active agents
    Patent number: 6136369
    Abstract: The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: October 24, 2000
    Assignee: IsoTis B.V.
    Inventors: Eugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai-Bo Wen, Klaas De Groot
  • Implant material
    Patent number: 6069295
    Abstract: The invention provides a nanotechnology process for implant surface treatment for producing an implant article. The nanotechnology process comprises subjecting a non-porous material to a mechanical or chemical surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm is obtained. The roughened surface can subsequently be subjected to precipitation of calcium phosphate from a solution containing calcium and phosphate ions.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: May 30, 2000
    Assignee: IsoTis B.V.
    Inventor: Eugenia Ribeiro de Sousa Fidalgo Leitao